Výsledky vyhledávání - "Cynthia L. Lichorowic"

Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure–Activity and Structure–Property Relationship Studies

Autor: Paul Willis, Sherwin Mashkouri, Roman Manetsch, Alexis N. LaCrue, Jordany R. Maignan, Andrii Monastyrskyi, Debora Casandra, Tina S. Mutka, Cynthia L. Lichorowic, Raghupathi Neelarapu, Dennis E. Kyle, Lynn D. Blake, Jeremy N. Burrows

Publikováno v: Journal of Medicinal Chemistry. 61:1450-1473

Malaria deaths have been decreasing over the last 10–15 years, with global mortality rates having fallen by 47% since 2000. While the World Health Organization (WHO) recommends the use of artemisinin-based combination therapies (ACTs) to combat mal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2176f749ffefeae0eec9181b5ef4f437
https://doi.org/10.1021/acs.jmedchem.7b00738

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ICI 56,780 Optimization: Structure-Activity Relationship Studies of 7-(2-Phenoxyethoxy)-4(1H)-quinolones with Antimalarial Activity

Autor: Roman Manetsch, Paul Willis, Debora Casandra, James Giarrusso, Dennis E. Kyle, Alexis N. LaCrue, Cynthia L. Lichorowic, Jeremy N. Burrows, Jordany R. Maignan, Tina S. Mutka, Lynn D. Blake

Publikováno v: J Med Chem

Malaria is estimated to have caused 584,000 deaths and 198 million cases of the disease globally in 2013. Though mortality rates are down 47% globally since 2000 and significant progress has been made in the quest for eradication, reported occurrence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6286ddf57c716f8d2510afef5537ed1
https://pubmed.ncbi.nlm.nih.gov/27291102

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