Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Cynthia L. Andoniadou"'
Autor:
Zidong Zhang, Michel Zamojski, Gregory R. Smith, Thea L. Willis, Val Yianni, Natalia Mendelev, Hanna Pincas, Nitish Seenarine, Mary Anne S. Amper, Mital Vasoya, Wan Sze Cheng, Elena Zaslavsky, Venugopalan D. Nair, Judith L. Turgeon, Daniel J. Bernard, Olga G. Troyanskaya, Cynthia L. Andoniadou, Stuart C. Sealfon, Frederique Ruf-Zamojski
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110467- (2022)
Summary: Despite their importance in tissue homeostasis and renewal, human pituitary stem cells (PSCs) are incompletely characterized. We describe a human single nucleus RNA-seq and ATAC-seq resource from pediatric, adult, and aged postmortem pituita
Externí odkaz:
https://doaj.org/article/9778f6fbae6c4b3ebc1fa18a2a9f30e3
Autor:
Emily J. Lodge, Paraskevi Xekouki, Tatiane S. Silva, Cristiane Kochi, Carlos A. Longui, Fabio R. Faucz, Alice Santambrogio, James L. Mills, Nathan Pankratz, John Lane, Dominika Sosnowska, Tina Hodgson, Amanda L. Patist, Philippa Francis-West, Françoise Helmbacher, Constantine A. Stratakis, Cynthia L. Andoniadou
Publikováno v:
JCI Insight, Vol 5, Iss 23 (2020)
Pituitary developmental defects lead to partial or complete hormone deficiency and significant health problems. The majority of cases are sporadic and of unknown cause. We screened 28 patients with pituitary stalk interruption syndrome for mutations
Externí odkaz:
https://doaj.org/article/44bddb906c75417c9a8501cac607a77e
Autor:
Laura D. Scriba, Stefan R. Bornstein, Alice Santambrogio, Gregor Mueller, Angela Huebner, Julia Hauer, Andreas Schedl, Ben Wielockx, Graeme Eisenhofer, Cynthia L. Andoniadou, Charlotte Steenblock
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Pheochromocytoma (PCC) and paraganglioma (PGL) are rare neuroendocrine tumors associated with high cardiovascular morbidity and variable risk of malignancy. The current therapy of choice is surgical resection. Nevertheless, PCCs/PGLs are associated w
Externí odkaz:
https://doaj.org/article/bdf993559ed14b2b864a618cb5c09b65
Autor:
Johanna Tommiska, Johanna Känsäkoski, Lasse Skibsbye, Kirsi Vaaralahti, Xiaonan Liu, Emily J. Lodge, Chuyi Tang, Lei Yuan, Rainer Fagerholm, Jørgen K. Kanters, Päivi Lahermo, Mari Kaunisto, Riikka Keski-Filppula, Sanna Vuoristo, Kristiina Pulli, Tapani Ebeling, Leena Valanne, Eeva-Marja Sankila, Sirpa Kivirikko, Mitja Lääperi, Filippo Casoni, Paolo Giacobini, Franziska Phan-Hug, Tal Buki, Manuel Tena-Sempere, Nelly Pitteloud, Riitta Veijola, Marita Lipsanen-Nyman, Kari Kaunisto, Patrice Mollard, Cynthia L. Andoniadou, Joel A. Hirsch, Markku Varjosalo, Thomas Jespersen, Taneli Raivio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Growth retardation is most commonly caused by genetic defects in the growth hormone pathway. Here, in families with growth retardation and gingival fibromatosis, the authors identify mutations in the potassium channel gene KCNQ1 that cause electrophy
Externí odkaz:
https://doaj.org/article/b5b12ca766544223adfa800c677fab94
Autor:
Jose Mario Gonzalez-Meljem, Scott Haston, Gabriela Carreno, John R. Apps, Sara Pozzi, Christina Stache, Grace Kaushal, Alex Virasami, Leonidas Panousopoulos, Seyedeh Neda Mousavy-Gharavy, Ana Guerrero, Mamunur Rashid, Nital Jani, Colin R. Goding, Thomas S. Jacques, David J. Adams, Jesus Gil, Cynthia L. Andoniadou, Juan Pedro Martinez-Barbera
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Senescent cells can promote tumour progression through the activation of a senescenceassociated secretory phenotype (SASP). Here, the authors show that SASP activation is associated with non-cell autonomous cell transformation and tumour initiation i
Externí odkaz:
https://doaj.org/article/a0474958863a4634a3e1c6faf8951dc5
Autor:
Valeria Scagliotti, Ruben Esse, Thea L. Willis, Mark Howard, Isabella Carrus, Emily Lodge, Cynthia L. Andoniadou, Marika Charalambous
Publikováno v:
Genes, Vol 12, Iss 4, p 509 (2021)
In mammals, imprinted genes regulate many critical endocrine processes such as growth, the onset of puberty and maternal reproductive behaviour. Human imprinting disorders (IDs) are caused by genetic and epigenetic mechanisms that alter the expressio
Externí odkaz:
https://doaj.org/article/14f335525b41465cae68c14c5668e866
Autor:
Judith Favier, Daniel A. Tennant, Eric Letouzé, Anne-Paule Gimenez-Roqueplo, Fatima Mechta-Grigoriou, Raphaël Rodriguez, Jennie Roberts, Lisa Vettore, Alpesh Thakker, Paule Bénit, Charlotte Lussey-Lepoutre, Cynthia L. Andoniadou, Theodora J. Stewart, Katarina Kluckova, Alexander P. Morrell, Sebastian Müller, Géraldine Gentric, Aurélie Morin, Sophie Moog, Judith Goncalves
Succinate dehydrogenase is a key enzyme in the tricarboxylic acid cycle and the electron transport chain. All four subunits of succinate dehydrogenase are tumor suppressor genes predisposing to paraganglioma, but only mutations in the SDHB subunit ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8344fed531abd70c4e2067dd3f8dac8
https://doi.org/10.1158/0008-5472.c.6513153.v1
https://doi.org/10.1158/0008-5472.c.6513153.v1
Autor:
Judith Favier, Daniel A. Tennant, Eric Letouzé, Anne-Paule Gimenez-Roqueplo, Fatima Mechta-Grigoriou, Raphaël Rodriguez, Jennie Roberts, Lisa Vettore, Alpesh Thakker, Paule Bénit, Charlotte Lussey-Lepoutre, Cynthia L. Andoniadou, Theodora J. Stewart, Katarina Kluckova, Alexander P. Morrell, Sebastian Müller, Géraldine Gentric, Aurélie Morin, Sophie Moog, Judith Goncalves
Supplementary Figure 1 - Supplementary Figure 2 - Supplementary Figure 3 - Supplementary Figure 4 - Supplementary Figure 5 - Supplementary Figure 6 - Supplementary Table 1 - Supplementary Table 2 - Supplementary Table 3 - Supplementary Table 4 - Supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14fa5c66a17bcd42509bb7c99b59f814
https://doi.org/10.1158/0008-5472.22428819
https://doi.org/10.1158/0008-5472.22428819
Autor:
Judith Favier, Daniel A. Tennant, Eric Letouzé, Anne-Paule Gimenez-Roqueplo, Fatima Mechta-Grigoriou, Raphaël Rodriguez, Jennie Roberts, Lisa Vettore, Alpesh Thakker, Paule Bénit, Charlotte Lussey-Lepoutre, Cynthia L. Andoniadou, Theodora J. Stewart, Katarina Kluckova, Alexander P. Morrell, Sebastian Müller, Géraldine Gentric, Aurélie Morin, Sophie Moog, Judith Goncalves
Supplementary Table 2 Related to Figure 2. Differentially methylated gene-based features in Sdhb-/- versus Sdhd-/- imCCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b04c08f42c8e0660b2c6f91c099c84
https://doi.org/10.1158/0008-5472.22428816.v1
https://doi.org/10.1158/0008-5472.22428816.v1
Publikováno v:
Cellular and Molecular Life Sciences. 79
Stem cells in the anterior pituitary gland can give rise to all resident endocrine cells and are integral components for the appropriate development and subsequent maintenance of the organ. Located in discreet niches within the gland, stem cells are