Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Cynthia L Frederiks"'
Autor:
Stephin J Vervoort, Olivier G de Jong, M Guy Roukens, Cynthia L Frederiks, Jeroen F Vermeulen, Ana Rita Lourenço, Laura Bella, Ana Tufegdzic Vidakovic, José L Sandoval, Cathy Moelans, Miranda van Amersfoort, Margaret J Dallman, Alejandra Bruna, Carlos Caldas, Edward Nieuwenhuis, Elsken van der Wall, Patrick Derksen, Paul van Diest, Marianne C Verhaar, Eric W-F Lam, Michal Mokry, Paul J Coffer
Publikováno v:
eLife, Vol 7 (2018)
The expression of the transcription factor SOX4 is increased in many human cancers, however, the pro-oncogenic capacity of SOX4 can vary greatly depending on the type of tumor. Both the contextual nature and the mechanisms underlying the pro-oncogeni
Externí odkaz:
https://doaj.org/article/36ce755b8cc24e3d9cea3f932f2ee24e
Autor:
Suze A. Jansen, Alessandro Cutilli, Coco de Koning, Marliek van Hoesel, Cynthia L. Frederiks, Leire Saiz Sierra, Stefan Nierkens, Michal Mokry, Edward E.S. Nieuwenhuis, Alan M. Hanash, Enric Mocholi, Paul J. Coffer, Caroline A. Lindemans
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110072- (2024)
Summary: The intestine is vulnerable to chemotherapy-induced damage due to the high rate of intestinal epithelial cell (IEC) proliferation. We have developed a human intestinal organoid-based 3D model system to study the direct effect of chemotherapy
Externí odkaz:
https://doaj.org/article/b237740e0ce446bdbb6f4231e7e5bc68
Autor:
Ana Rita Lourenço, M. Guy Roukens, Danielle Seinstra, Cynthia L. Frederiks, Cornelieke E. Pals, Stephin J. Vervoort, Andreia S. Margarido, Jacco van Rheenen, Paul J. Coffer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
In breast cancer TGF-β regulates C/EBPα and can induce epithelial-to-mesenchymal transition (EMT). Here, the authors show that C/EBPα maintains epithelial homeostasis and prevents EMT-mediated tumorigenesis.
Externí odkaz:
https://doaj.org/article/beb8ddfc0b0b4b249f1fbb7841a7699b
Autor:
M Guy Roukens, Jeroen F. Vermeulen, Cynthia L Frederiks, Margaret J. Dallman, Michal Mokry, Miranda van Amersfoort, Cathy B. Moelans, Ana Rita Lourenço, Carlos Caldas, Eric Lam, Edward E. S. Nieuwenhuis, Paul J. van Diest, Stephin J. Vervoort, Olivier G. de Jong, Elsken van der Wall, Alejandra Bruna, Paul J. Coffer, Laura Bella, Patrick W. B. Derksen, José Luis Sandoval, Marianne C. Verhaar, Ana Tufegdzic Vidakovic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e77ccb0abc065b87f26a5e51d97c3e3a
https://doi.org/10.7554/elife.27706.036
https://doi.org/10.7554/elife.27706.036
Autor:
Alejandra Bruna, Carlos Caldas, Cynthia L Frederiks, Stephin J. Vervoort, José Luis Sandoval, Cornelieke Pals, Oscar M. Rueda, Ana Tufegdzic Vidakovic, Janneke G. C. Peeters, Ana Rita Lourenço, Enric Mocholi, Paul J. Coffer
Publikováno v:
Nucleic Acids Research, 46(18), 9578. Oxford University Press
Nucleic Acids Research
Nucleic Acids Research
Expression of the transcription factor SOX4 is often elevated in human cancers, where it generally correlates with tumor-progression and poor-disease outcome. Reduction of SOX4 expression results in both diminished tumor-incidence and metastasis. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe4d6567d8d50aab4a23c0fc0557a76
https://www.repository.cam.ac.uk/handle/1810/286942
https://www.repository.cam.ac.uk/handle/1810/286942