Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Cynthia J. Wolf"'
Publikováno v:
PPAR Research, Vol 2010 (2010)
Perfluorononanoic acid (PFNA) is one of the perfluoroalkyl acids found in the environment and in tissues of humans and wildlife. Prenatal exposure to PFNA negatively impacts survival and development of mice and activates the mouse and human peroxisom
Externí odkaz:
https://doaj.org/article/b7b139af374b43bebad8efbaa13bec46
Autor:
Carmen R. Wood, Sierra D Moorefield, Carrie M. Becker, Cynthia J. Wolf, David G. Belair, Barbara D. Abbott
Publikováno v:
Toxicological Sciences.
Embryologic development involves cell differentiation and organization events that are unique to each tissue and organ and are susceptible to developmental toxicants. Animal models are the gold standard for identifying putative teratogens, but the li
Autor:
David G. Belair, Barbara D. Abbott, Judith E. Schmid, Carrie M. Becker, Cynthia J. Wolf, Kaberi P. Das
Publikováno v:
Birth defects research. 110(17)
Background Cleft palate (CP) is a common birth defect, occurring in an estimated 1 in 1,000 births worldwide. The secondary palate is formed by paired palatal shelves, consisting of a mesenchymal core with an outer layer of epithelial cells that grow
Autor:
Cynthia J. Wolf, Denise MacMillan, Adam Swank, David G. Belair, William T. Padgett, Rachel Grindstaff, Witold Winnik, Carmen R. Wood, Anna Fisher, Barbara D. Abbott, Hongzu Ren
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184155 (2017)
PLoS ONE
PLoS ONE
Epithelial-mesenchymal interactions drive embryonic fusion events during development, and perturbations of these interactions can result in birth defects. Cleft palate and neural tube defects can result from genetic defects or environmental exposures
Publikováno v:
Reproductive Toxicology. 33:546-551
Perfluorinated alkyl acids (PFAAs) are manufactured surfactants found globally in the environment and in tissues of humans and wildlife. Several PFAAs adversely affect rodents and activation of PPARα is thought to be their mode of action. Our previo
Publikováno v:
PPAR Research
PPAR Research, Vol 2010 (2010)
PPAR Research, Vol 2010 (2010)
Perfluorononanoic acid (PFNA) is one of the perfluoroalkyl acids found in the environment and in tissues of humans and wildlife. Prenatal exposure to PFNA negatively impacts survival and development of mice and activates the mouse and human peroxisom
Autor:
Cynthia J. Wolf, Antonia M. Calafat, Earl L. Gray, Kayoko Kato, Larry L. Needham, Manori J. Silva
Publikováno v:
Toxicology. 210:123-133
Di-n-octyl phthalate (DnOP) is a plasticizer used in polyvinyl chloride plastics, cellulose esters, and polystyrene resins. The metabolism of DnOP results in the hydrolysis of one ester linkage to produce mono-n-octyl phthalate (MnOP), which subseque
Publikováno v:
Toxicological Sciences. 78:135-143
In mammals, androgens are essential in directing mammalian sexual differentiation of the male phenotype. Administration of testosterone during this period alters female development in a male-like direction, whereas exposure to an androgen receptor an
Autor:
Cynthia J. Wolf, Leon Earl Gray, Joseph S. Ostby, S.J. Degitz, J.E. Tietge, Ralph L. Cooper, K.M. Jensen, M. Price, Christy S. Lambright, Phillip C. Hartig, Andrew K. Hotchkiss, Tammy E. Stoker, Vickie S. Wilson, E.A. Makynen, J.J. Korte, Johnathan Furr, Kathy Bobseine, M.D. Kahl, Gerald T. Ankley, Louise G. Parks, Susan C. Laws
Publikováno v:
Toxicology. :371-382
The US Environmental Protection Agency (EPA) is developing a screening and testing program for endocrine disrupting chemicals (EDCs) to detect alterations of hypothalamic–pituitary–gonadal (HPG) function, estrogen (ER), androgen (AR) and thyroid
Publikováno v:
Toxicological Sciences. 51:259-264
Low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), administered as a single dose to the dam during gestation, alter development of the fetal rodent reproductive system. In male rat and hamster offspring, dosing with TCDD during gestation reduce