Výsledky vyhledávání - "Cynthia J. Gordon"

RANTES (CCL5) uses the proteoglycan CD44 as an auxiliary receptor to mediate cellular activation signals and HIV-1 enhancement

Autor: Christine Leemann, Alexandra Trkola, Amapola Manrique, Cynthia J. Gordon, Branka Roscic-Mrkic, Marek Fischer, Amanda E. I. Proudfoot, John P. Moore

Publikováno v: Blood. 102:1169-1177

The CC-chemokine RANTES (regulated on activation normal T-cell expressed and secreted; CCL5) transduces multiple intracellular signals. Like all chemokines, it stimulates G protein–coupled receptor (GPCR) activity through interaction with its cogna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b70af35d0d600d47c669cc27ea3e95
https://doi.org/10.1182/blood-2003-02-0488

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Genetic Diversity of Primary HIV-1 Isolates and Their Sensitivity to Antibody-Mediated Neutralization

Autor: Eric Delwart, Cynthia J. Gordon

Publikováno v: Virology. 272:326-330

Wide differences exist among primary isolates of HIV-1 in their sensitivity to antibody-mediated neutralization. While it is well documented that even short-term tissue culture amplification of HIV-1 leads to a reduction in the genetic diversity of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e1fa45323218ea6d17b1be9074d464
https://doi.org/10.1006/viro.2000.0400

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A Cell Line-Based Neutralization Assay for Primary Human Immunodeficiency Virus Type 1 Isolates That Use either the CCR5 or the CXCR4 Coreceptor

Autor: John P. Moore, Jamie Matthews, Alexandra Trkola, Tom Ketas, Cynthia J. Gordon

Publikováno v: Europe PubMed Central

We describe here a cell line-based assay for the evaluation of human immunodeficiency virus type 1 (HIV-1) neutralization. The assay is based on CEM.NKR cells, transfected to express the HIV-1 coreceptor CCR5 to supplement the endogenous expression o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5a75a9aea014b4ac9c70de5c646133
https://doi.org/10.1128/jvi.73.11.8966-8974.1999

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The CC-Chemokine RANTES Increases the Attachment of Human Immunodeficiency Virus Type 1 to Target Cells via Glycosaminoglycans and Also Activates a Signal Transduction Pathway That Enhances Viral Infectivity

Autor: Cynthia J. Gordon, Lloyd Czaplewski, Tom Ketas, Elizabeth S. Maxwell, Jamie Matthews, Alexandra Trkola, Amanda E. I. Proudfoot, John P. Moore

Publikováno v: Europe PubMed Central

We have studied the mechanisms by which the CC-chemokine RANTES can enhance the infectivities of human immunodeficiency virus type 1 (HIV-1) and other enveloped viruses, when present at concentrations in excess of 500 ng/ml in vitro. Understanding th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015a0e0f328e6564f7af2cb24893ccd8
https://doi.org/10.1128/jvi.73.8.6370-6379.1999

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Enhancement of Human Immunodeficiency Virus Type 1 Infection by the CC-Chemokine RANTES Is Independent of the Mechanism of Virus-Cell Fusion

Autor: Christine A. Power, Alexandra Trkola, John P. Moore, Mark A. Muesing, Amanda E. I. Proudfoot, Cynthia J. Gordon

Publikováno v: Europe PubMed Central

We have studied the effects of CC-chemokines on human immunodeficiency virus type 1 (HIV-1) infection, focusing on the infectivity enhancement caused by RANTES. High RANTES concentrations increase the infectivity of HIV-1 isolates that use CXC-chemok

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337fa582024f6d70fa36acaec316bfb8
https://doi.org/10.1128/jvi.73.1.684-694.1999

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Interaction of Chemokine Receptor CCR5 with its Ligands: Multiple Domains for HIV-1 gp120 Binding and a Single Domain for Chemokine Binding

Autor: Charles R. Mackay, Nancy Ruffing, Greg LaRosa, Howard H. Chen, Nasim Kassam, Heidi Heath, Michel Samson, Lijun Wu, Marc Parmentier, John P. Moore, Jason Humblias, Cynthia J. Gordon

Publikováno v: ResearcherID
The Journal of Experimental Medicine

CCR5 is a chemokine receptor expressed by T cells and macrophages, which also functions as the principal coreceptor for macrophage (M)-tropic strains of HIV-1. To understand the molecular basis of the binding of chemokines and HIV-1 to CCR5, we devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd3bfef3039dbe5284f72703850c508
https://doi.org/10.1084/jem.186.8.1373

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Tracking Changes in HIV-1 Envelope Quasispecies Using DNA Heteroduplex Analysis

Autor: Eric Delwart, Cynthia J. Gordon

Publikováno v: Methods. 12:348-354

A DNA heteroduplex tracking assay (HTA) using single-stranded probes is described. This assay provides a rapid means of resolving genetic variants coamplified by PCR and of measuring the level of particular variants in complex populations. To confide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1903557acb3f3032352345b6bac176b
https://doi.org/10.1006/meth.1997.0489

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Sexual Symmetry in Psychiatric Diagnosis

Autor: Tasnim Khomusi, Jo Dixon, Cynthia J. Gordon

Publikováno v: Social Problems. 42:429-448

While proponents of the psychiatric perspective submit that diagnosis using DSM is sex symmetrical, i.e., males and females with similar mental illness symptoms receive the same diagnosis, followers of the labeling perspective argue that diagnosis is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1378f9ac46bd93a0496aefc469ad87e0
https://doi.org/10.1525/sp.1995.42.3.03x0106b

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Interaction of the CC-chemokine RANTES with glycosaminoglycans activates a p44/p42 mitogen-activated protein kinase-dependent signaling pathway and enhances human immunodeficiency virus type 1 infectivity

Autor: Alexandra Trkola, Amanda E. I. Proudfoot, John P. Moore, Theresa L. Chang, Christine A. Power, Branka Roscic-Mrkic, Cynthia J. Gordon

Publikováno v: Journal of virology. 76(5)

The interaction of the CC-chemokine RANTES with its cell surface receptors transduces multiple intracellular signals: low concentrations of RANTES (1 to 10 nM) stimulate G-protein-coupled receptor (GPCR) activity, and higher concentrations (1 μM) ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230f4f654db00f470e5e081f2965c7d1
https://pubmed.ncbi.nlm.nih.gov/11836402

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