Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Cynthia J Guidos"'
Autor:
Marina E Tourlakis, Siyi Zhang, Heather L Ball, Rikesh Gandhi, Hongrui Liu, Jian Zhong, Julie S Yuan, Cynthia J Guidos, Peter R Durie, Johanna M Rommens
Publikováno v:
PLoS Genetics, Vol 11, Iss 6, p e1005288 (2015)
Genetic models of ribosome dysfunction show selective organ failure, highlighting a gap in our understanding of cell-type specific responses to translation insufficiency. Translation defects underlie a growing list of inherited and acquired cancer-pr
Externí odkaz:
https://doaj.org/article/856671ca104e4135a514d8fa8c538e54
Autor:
Craig A Gedye, Ali Hussain, Joshua Paterson, Alannah Smrke, Harleen Saini, Danylo Sirskyj, Keira Pereira, Nazleen Lobo, Jocelyn Stewart, Christopher Go, Jenny Ho, Mauricio Medrano, Elzbieta Hyatt, Julie Yuan, Stevan Lauriault, Mona Meyer, Maria Kondratyev, Twan van den Beucken, Michael Jewett, Peter Dirks, Cynthia J Guidos, Jayne Danska, Jean Wang, Bradly Wouters, Benjamin Neel, Robert Rottapel, Laurie E Ailles
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105602 (2014)
Cell surface proteins have a wide range of biological functions, and are often used as lineage-specific markers. Antibodies that recognize cell surface antigens are widely used as research tools, diagnostic markers, and even therapeutic agents. The a
Externí odkaz:
https://doaj.org/article/26b8358f2d6c4080bcea0ab7bd509e76
Autor:
Thomas R Cawthorn, Juan C Moreno, Moyez Dharsee, Danh Tran-Thanh, Suzanne Ackloo, Pei Hong Zhu, Girish Sardana, Jian Chen, Peter Kupchak, Lindsay M Jacks, Naomi A Miller, Bruce J Youngson, Vladimir Iakovlev, Cynthia J Guidos, Katherine A Vallis, Kenneth R Evans, David McCready, Wey L Leong, Susan J Done
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30992 (2012)
Breast cancer is the most common malignancy among women worldwide in terms of incidence and mortality. About 10% of North American women will be diagnosed with breast cancer during their lifetime and 20% of those will die of the disease. Breast cance
Externí odkaz:
https://doaj.org/article/5a7c1d53549b400eae687487a3a338ef
Autor:
Ori Scott, Shagana Visuvanathan, Emily Reddy, Deeqa Mahamed, Bin Gu, Chaim M. Roifman, Ronald D. Cohn, Cynthia J. Guidos, Evgueni A. Ivakine
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionHumans with gain-of-function (GOF) mutations in STAT1 (Signal Transducer and Activator of Transcription 1), a potent immune regulator, experience frequent infections. About one-third, especially those with DNA-binding domain (DBD) mutatio
Externí odkaz:
https://doaj.org/article/a92971508e374a85a787e6e51acaca8e
Autor:
Arvind Singh Mer, Emily M. Heath, Seyed Ali Madani Tonekaboni, Nergiz Dogan-Artun, Sisira Kadambat Nair, Alex Murison, Laura Garcia-Prat, Liran Shlush, Rose Hurren, Veronique Voisin, Gary D. Bader, Corey Nislow, Mattias Rantalainen, Soren Lehmann, Mark Gower, Cynthia J. Guidos, Mathieu Lupien, John E. Dick, Mark D. Minden, Aaron D. Schimmer, Benjamin Haibe-Kains
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Molecular heterogeneity of acute myeloid leukaemia (AML) across patients is a major challenge for prognosis and therapy. Here, the authors show that NPM1 mutated AML is a heterogeneous class, consisting of two subtypes which exhibit distinct molecula
Externí odkaz:
https://doaj.org/article/a1a1fb4ad66d4a54b1ec1c09785a2551
Autor:
John E. Dick, Charles G. Mullighan, Quaid Morris, Mark D. Minden, Jinghui Zhang, Jayne S. Danska, Cynthia J. Guidos, John Easton, Gary Bader, Steven M. Chan, Geoffrey Neale, Scott R. Olsen, Ying Shao, Michael Rusch, Pankaj Gupta, Sagi Abelson, Mohsen Hosseini, Stephanie Z. Xie, Michelle Chan-Seng-Yue, Veronique Voisin, Yiping Fan, Xiaotu Ma, Michael N. Edmonson, Debbie Payne-Turner, Ildiko Grandal, Olga I. Gan, Jessica McLeod, Zhaohui Gu, Esmé Waanders, Jeffrey Wintersinger, Robert J. Vanner, Laura García-Prat, Stephanie M. Dobson
Targeted-sequencing analysis of PDX and PairTree predicted mutational population clusters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823eb2ad063b0558407f0bcc5e8a0bf0
https://doi.org/10.1158/2159-8290.22535185
https://doi.org/10.1158/2159-8290.22535185
Autor:
John E. Dick, Charles G. Mullighan, Quaid Morris, Mark D. Minden, Jinghui Zhang, Jayne S. Danska, Cynthia J. Guidos, John Easton, Gary Bader, Steven M. Chan, Geoffrey Neale, Scott R. Olsen, Ying Shao, Michael Rusch, Pankaj Gupta, Sagi Abelson, Mohsen Hosseini, Stephanie Z. Xie, Michelle Chan-Seng-Yue, Veronique Voisin, Yiping Fan, Xiaotu Ma, Michael N. Edmonson, Debbie Payne-Turner, Ildiko Grandal, Olga I. Gan, Jessica McLeod, Zhaohui Gu, Esmé Waanders, Jeffrey Wintersinger, Robert J. Vanner, Laura García-Prat, Stephanie M. Dobson
Disease recurrence causes significant mortality in B-progenitor acute lymphoblastic leukemia (B-ALL). Genomic analysis of matched diagnosis and relapse samples shows relapse often arising from minor diagnosis subclones. However, why therapy eradicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eeae57e85ce8eee3b714e0c6251c039b
https://doi.org/10.1158/2159-8290.c.6547777.v1
https://doi.org/10.1158/2159-8290.c.6547777.v1
Autor:
Pamela S. Ohashi, Marcus Q. Bernardini, Trevor J. Pugh, Cynthia J. Guidos, Michael Reedijk, David R. McCready, Wey L. Leong, Alexandra Easson, Ayman Al-Habeeb, Danny Ghazarian, Blaise A. Clarke, Patricia A. Shaw, Sarah Rachel Katz, S.Y. Cindy Yang, Simone C. Stone, Linh T. Nguyen, Aras Toker
Flow cytometry analysis of intratumoral Treg cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d8cdf1fcf96042e27dbf3236d292d7
https://doi.org/10.1158/1078-0432.22470540.v1
https://doi.org/10.1158/1078-0432.22470540.v1
Autor:
Uri Tabori, Zachary F. Pursell, Cynthia J. Guidos, Cynthia E. Hawkins, James G. Jackson, Zucai Suo, Eric Bouffet, Adam Shlien, Alberto Martin, Carol Durno, Oz Mordechai, Jonathan N. Byrd, Gavin P. Dunn, Tomasz Sarosiek, Andrea Seeley, Jagadeesh Ramdas, Xia Wang, Melyssa Aronson, Nuno M. Nunes, Victoria J. Forster, Jiil Chung, Dana Elshaer, Richard de Borja, Melissa Edwards, Robert Siddaway, Iram Siddiqui, Lazar Joksimovic, Ayse B. Ercan, Vivian S. Park, Nathan A. Ungerleider, Walter J. Zahurancik, Taylor Bridge, Sumedha Sudhaman, Miki S. Gams, Karl P. Hodel, Melissa A. Galati
Supplementary Figure S1 (related to Figure 1): PoleP286R mouse model design, validation, and tumor findings. Supplementary Figure S2 (related to Figure 1): PoleS459F mouse model design, validation, and tumor findings. Supplementary Figure S3 (related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be86ccbe1dd1695c7f2fa2cfc56c0fe6
https://doi.org/10.1158/0008-5472.22427518.v1
https://doi.org/10.1158/0008-5472.22427518.v1
Autor:
Uri Tabori, Zachary F. Pursell, Cynthia J. Guidos, Cynthia E. Hawkins, James G. Jackson, Zucai Suo, Eric Bouffet, Adam Shlien, Alberto Martin, Carol Durno, Oz Mordechai, Jonathan N. Byrd, Gavin P. Dunn, Tomasz Sarosiek, Andrea Seeley, Jagadeesh Ramdas, Xia Wang, Melyssa Aronson, Nuno M. Nunes, Victoria J. Forster, Jiil Chung, Dana Elshaer, Richard de Borja, Melissa Edwards, Robert Siddaway, Iram Siddiqui, Lazar Joksimovic, Ayse B. Ercan, Vivian S. Park, Nathan A. Ungerleider, Walter J. Zahurancik, Taylor Bridge, Sumedha Sudhaman, Miki S. Gams, Karl P. Hodel, Melissa A. Galati
POLE mutations are a major cause of hypermutant cancers, yet questions remain regarding mechanisms of tumorigenesis, genotype–phenotype correlation, and therapeutic considerations. In this study, we establish mouse models harboring cancer-associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b21c938f653fba762197235f84abd90d
https://doi.org/10.1158/0008-5472.c.6512707.v1
https://doi.org/10.1158/0008-5472.c.6512707.v1