Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Cynthia Horth"'
Autor:
Katarzyna B. Leszczynska, Amanda Freitas-Huhtamäki, Chinchu Jayaprakash, Monika Dzwigonska, Francisca N.L. Vitorino, Cynthia Horth, Kamil Wojnicki, Bartlomiej Gielniewski, Paulina Szadkowska, Beata Kaza, Javad Nazarian, Maciej K. Ciolkowski, Joanna Trubicka, Wieslawa Grajkowska, Benjamin A. Garcia, Jacek Majewski, Bozena Kaminska, Jakub Mieczkowski
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113707- (2024)
Summary: Diffuse intrinsic pontine gliomas (DIPGs) are deadly pediatric brain tumors, non-resectable due to brainstem localization and diffusive growth. Over 80% of DIPGs harbor a mutation in histone 3 (H3.3 or H3.1) resulting in a lysine-to-methioni
Externí odkaz:
https://doaj.org/article/590589af8239422c9bd340fc8f43c4fa
Autor:
Nargess Farhangdoost, Cynthia Horth, Bo Hu, Eric Bareke, Xiao Chen, Yinglu Li, Mariel Coradin, Benjamin A. Garcia, Chao Lu, Jacek Majewski
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108769- (2021)
Summary: Chromatin dysregulation has emerged as an important mechanism of oncogenesis. To develop targeted treatments, it is important to understand the transcriptomic consequences of mutations in chromatin modifier genes. Recently, mutations in the
Externí odkaz:
https://doaj.org/article/fdfe19949dae4154a4bffa104cdbb0ba
Autor:
Ashot S. Harutyunyan, Haifen Chen, Tianyuan Lu, Cynthia Horth, Hamid Nikbakht, Brian Krug, Caterina Russo, Eric Bareke, Dylan M. Marchione, Mariel Coradin, Benjamin A. Garcia, Nada Jabado, Jacek Majewski
Publikováno v:
Cell Reports, Vol 33, Iss 7, Pp 108390- (2020)
Summary: The discovery of H3K27M mutations in pediatric gliomas marked a new chapter in cancer epigenomics. Numerous studies have investigated the effect of this mutation on H3K27 trimethylation, but only recently have we started to realize its addit
Externí odkaz:
https://doaj.org/article/ad26cd7d47e94a5684d71e175b0b6da1
Autor:
Douglas Barrows, Matthew R. Marunde, C. David Allis, Xiao Chen, Cynthia Horth, Phillip Rosenbaum, Michael-Christopher Keogh, Daniel N. Weinberg, Irina K. Popova, Chao Lu, Jacek Majewski, Zachary B. Gillespie
Publikováno v:
Nat Genet
Precise deposition of CpG methylation is critical for mammalian development and tissue homeostasis and is often dysregulated in human diseases. The localization of de novo DNA methyltransferase DNMT3A is facilitated by its PWWP domain recognizing his
Autor:
Haifen Chen, Bo Hu, Cynthia Horth, Eric Bareke, Phillip Rosenbaum, Sin Young Kwon, Jacinthe Sirois, Daniel N. Weinberg, Faith M. Robison, Benjamin A. Garcia, Chao Lu, William A. Pastor, Jacek Majewski
Publikováno v:
Genome Research.
Epigenetic modifications on the chromatin do not occur in isolation. Chromatin-associated proteins and their modification products form a highly interconnected network, and disturbing one component may rearrange the entire system. We see this increas
Autor:
Yinglu Li, Elizabeth M. Goldberg, Xiao Chen, Xinjing Xu, John T. McGuire, Giuseppe Leuzzi, Dimitris Karagiannis, Tiffany Tate, Nargess Farhangdoost, Cynthia Horth, Esther Dai, Zhiming Li, Zhiguo Zhang, Benjamin Izar, Jianwen Que, Alberto Ciccia, Jacek Majewski, Angela J. Yoon, Laurie Ailles, Cathy Lee Mendelsohn, Chao Lu
Publikováno v:
Molecular Cell. 82:3901-3918.e7
How cancer-associated chromatin abnormalities shape tumor-immune interaction remains incompletely understood. Recent studies have linked DNA hypomethylation and de-repression of retrotransposons to anti-tumor immunity through the induction of interfe
Autor:
Marcus A. Cheek, Michael-Christopher Keogh, John T. McGuire, Matthew R. Marunde, Daniel N. Weinberg, Simon Papillon-Cavanagh, Kartik N. Rajagopalan, Chao Lu, Haitao Li, Nada Jabado, Jacek Majewski, Yuan Yue, Anissa Djedid, Eric Bareke, Xinjing Xu, Ashot S. Harutyunyan, Xiao Chen, Agata E. Lemiesz, Cynthia Horth, Hamid Nikbakht, Matthew J. Meiners, Haifen Chen, Dylan M. Marchione, Benjamin A. Garcia, C. David Allis
Publikováno v:
Nature
Enzymes that catalyse CpG methylation in DNA, including the DNA methyltransferases 1 (DNMT1), 3A (DNMT3A) and 3B (DNMT3B), are indispensable for mammalian tissue development and homeostasis1–4. They are also implicated in human developmental disord
Autor:
Chao Lu, Jacek Majewski, Bo Hu, Yinglu Li, Nargess Farhangdoost, Benjamin A. Garcia, Mariel Coradin, Xiao Chen, Cynthia Horth, Eric Bareke
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108769-(2021)
Cell reports
Cell reports
SUMMARY Chromatin dysregulation has emerged as an important mechanism of oncogenesis. To develop targeted treatments, it is important to understand the transcriptomic consequences of mutations in chromatin modifier genes. Recently, mutations in the h
Autor:
Bo Hu, Chao Lu, Jacek Majewski, Benjamin A. Garcia, Yinglu Li, Xiao Chen, Cynthia Horth, Mariel Coradin, Nargess Farhangdoost, Eric Bareke
Epigenetic dysregulation has emerged as an important mechanism of oncogenesis. To develop targeted treatments, it is important to understand the epigenetic and transcriptomic consequences of mutations in epigenetic modifier genes. Recently, mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c15dd92590a5708aaceca535581a8c0
https://doi.org/10.1101/2020.05.30.124057
https://doi.org/10.1101/2020.05.30.124057
Autor:
Brian Krug, Tianyuan Lu, Benjamin A. Garcia, Eric Bareke, Caterina Russo, Nada Jabado, Haifen Chen, Mariel Coradin, Cynthia Horth, Dylan M. Marchione, Jacek Majewski, Hamid Nikbakht, Ashot S. Harutyunyan
Publikováno v:
SSRN Electronic Journal.
The discovery of H3K27M mutations in pediatric gliomas marked a new chapter in cancer epigenetics. Numerous studies have investigated the effect of this mutation on H3K27 trimethylation, but only recently have we started to realize its additional eff