Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Cynthia Hess, Kenny"'
Autor:
Olaniyi Olarewaju, Franziska Held, Pamela Curtis, Cynthia Hess Kenny, Udo Maier, Tadas Panavas, Francois du Plessis
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101378- (2024)
Due to the refractiveness of tumor tissues to adeno-associated virus (AAV) transduction, AAV vectors are poorly explored for cancer therapy delivery. Here, we aimed to engineer AAVs to target tumors by enabling the specific engagement of fibroblast a
Externí odkaz:
https://doaj.org/article/953471efcaa54a97877e67b01b80d553
Autor:
Maria Myzithras, Siqi Lin, Legairre Radden, Cynthia Hess Kenny, Zheng Cai, Angus MacDonald, Ralph Binetti, Michael Marlow, Paul Fracasso, Glenn Gibson, Christina Bartlett, Julie Hawkins, Steven Hansel
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
An in-house antibody generation campaign identified a diverse, high affinity set of anti-interleukin-11 (IL-11) monoclonal antibodies (mAbs) to enable successful development of novel, custom ultra-sensitive target engagement assays for detection of
Externí odkaz:
https://doaj.org/article/95c843a47adf43968a193c2a06c2f1f5
Autor:
Nina Zippel, Cynthia Hess Kenny, Helen Wu, Michel Garneau, Rachel Kroe-Barrett, Priyanka Gupta, Sarah Low, Remko A. Bakker, Leo Thomas
Publikováno v:
Translational vision sciencetechnology. 11(6)
Semaphorin 3A (Sema3A) is an axonal guidance molecule that inhibits angiogenesis by vasorepulsion and blocks revascularization in the ischemic retina. BI-X is an intravitreal anti-Sema3A agent under clinical investigation in patients with proliferati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd223a432a4a336705774bc25be20dfd
https://pubmed.ncbi.nlm.nih.gov/35727188
https://pubmed.ncbi.nlm.nih.gov/35727188
Autor:
Erica Waltz, Rachel Kroe-Barrett, Tammy Bigwarfe, Sarah Low, John Miglietta, Hua Li, Cynthia Hess Kenny, Maria Myzithras, Jennifer Ahlberg, Irina Rybina
Publikováno v:
Bioanalysis. 10:397-406
Aim: The fully automated microfluidics-based Gyrolab is a popular instrument for the bioanalysis of protein therapeutics; requiring minimal sample and reagent volumes. Gyros offers affinity software for determining binding affinity in solution using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d754d041ec368ad7e12747657cf77d90
https://doi.org/10.4155/bio-2017-0251
https://doi.org/10.4155/bio-2017-0251
Autor:
Maria Myzithras, Erica Waltz, Irina Rybina, Zhong-Fu Huang, Jennifer Ahlberg, Tammy Bigwarfe, Haiguang Xiao, Rachel Kroe-Barrett, Marcio O. Lasaro, Himanshu Saraf, Simon Roberts, Cynthia Hess Kenny, Danlin Yang, Steven Castellano, Sanjaya Singh, Craig Giragossian
Publikováno v:
mAbs
Antibodies with pH-dependent binding to both target antigens and neonatal Fc receptor (FcRn) provide an alternative tool to conventional neutralizing antibodies, particularly for therapies where reduction in antigen level is challenging due to high t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53eac44c654c862fa41923786e5554e5
https://doi.org/10.1080/19420862.2017.1359455
https://doi.org/10.1080/19420862.2017.1359455
Autor:
David Presky, Qi Pan, Amy Marie Nicoletti, Ashraf Khalil, Scott M DeWire, Kerry L. M. Ralph, Sathyadevi Venkataramani, Julie Ritchie, Brodeur Scott, Cynthia Hess Kenny
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 359:37-44
Therapeutic agents antagonizing B-cell-activating factor/B-lymphocyte stimulator (BAFF/BLyS) are currently in clinical development for autoimmune diseases; belimumab is the first Food and Drug Administration-approved drug in more than 50 years for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b356f2605b1dfb81b3702deb9c59840d
https://doi.org/10.1124/jpet.116.236075
https://doi.org/10.1124/jpet.116.236075
Autor:
Lee D, Jennings, Kenneth W, Foreman, Thomas S, Rush, Desiree H H, Tsao, Lidia, Mosyak, Scott L, Kincaid, Mohani N, Sukhdeo, Alan G, Sutherland, Weidong, Ding, Cynthia Hess, Kenny, Chantel L, Sabus, Hanlan, Liu, Elizabeth G, Dushin, Soraya L, Moghazeh, Pornpen, Labthavikul, Peter J, Petersen, Margareta, Tuckman, Steven A, Haney, Alexey V, Ruzin
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:5115-5131
The ZipA–FtsZ protein–protein interaction is a potential target for antibacterial therapy. The design and parallel synthesis of a combinatorial library of small molecules, which target the FtsZ binding area on ZipA are described. Compounds were d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41000540d428bfc3965e4aaf6d9608f0
https://doi.org/10.1016/j.bmc.2004.07.031
https://doi.org/10.1016/j.bmc.2004.07.031
Autor:
Ronald W. Kriz, Weidong Ding, Cynthia Hess Kenny, Alan G. Sutherland, Susan Benard, Kerry Kelleher, George Ellestad, Elizabeth G. Dushin, Lidia Mosyak
Publikováno v:
Analytical Biochemistry. 323:224-233
A fluorescence polarization competition assay has been developed to screen for inhibitors of the Escherichia coli FtsZ/ZipA protein-protein interaction. A previously published X-ray costructure demonstrated that a 17-amino-acid peptide, corresponding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153a53c1dc84e271c1fcbcccfd274250
https://doi.org/10.1016/j.ab.2003.08.033
https://doi.org/10.1016/j.ab.2003.08.033
Autor:
Karen L. Wheless, Desiree H.H. Tsao, Weidong Ding, Juan C. Alvarez, Alexey Ruzin, Kenneth Foreman, Alan G. Sutherland, Pornpen Labthavikul, Lidia Mosyak, Thomas S. Rush, Peter Petersen, Cynthia Hess Kenny
Publikováno v:
Org. Biomol. Chem.. 1:4138-4140
Structural features of two weak inhibitors of the ZipA-FtsZ protein-protein interaction which were found to bind to overlapping but different areas of the key binding site were combined in one new series of carboxybiphenyl-indoles with improved inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17957a03436d9d6ffc5f8b8c5e265c65
https://doi.org/10.1039/b312016c
https://doi.org/10.1039/b312016c
Autor:
Lori M. Miller, Scott C. Mayer, Dan M. Berger, Diane H. Boschelli, Frank Boschelli, Li Di, Xuemei Du, Minu Dutia, Middleton B. Floyd, Mark Johnson, Cynthia Hess Kenny, Girija Krishnamurthy, Franklin Moy, Susan Petusky, Diane Tkach, Nancy Torres, Biqi Wu, Weixin Xu
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(1)
Insulin-like growth factor receptor (IGF-1R) is a growth factor receptor tyrosine kinase that acts as a critical mediator of cell proliferation and survival. Inhibitors of this receptor are believed to provide a new target in cancer therapy. We previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7e8177a0b3fe09ae56aef3f36f2b22
https://pubmed.ncbi.nlm.nih.gov/19041240
https://pubmed.ncbi.nlm.nih.gov/19041240