Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Cynthia H. O'Callaghan"'
Publikováno v:
Antimicrobial Agents and Chemotherapy. 10:245-248
A cephalosporin, (6R,7R)-7-[(2R)-2-hydroxy-2-phenylacetamido]-3-(pyrid-2-yl- N -oxide) thiomethylceph-3-em-4-carboxylic acid (MCO), that could lead to a novel approach to the problem of β-lactamase destruction is described. The compound is slightly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ffb7b60211283099e24bd6d9159747
https://doi.org/10.1128/aac.10.2.245
https://doi.org/10.1128/aac.10.2.245
Publikováno v:
The Journal of Antibiotics. 29:29-37
Cefuroxime is a new broad spectrum cephalosporin antibiotic for administration by injection. It is stable to most beta-lactamases. It is active against gram-positive organisms, including penicillinase-producing staphylococci, and has wide activity ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a129694f6047055acf51515b4016dfb1
https://doi.org/10.7164/antibiotics.29.29
https://doi.org/10.7164/antibiotics.29.29
Publikováno v:
Antimicrobial Agents and Chemotherapy. 9:511-519
Cefuroxime is a new broad-spectrum cephalosporin antibiotic with increased stability to β-lactamases. This stability, although no absolute in all cases, has the effect of widening the antibacterial spectrum of the compound so that many organisms res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a765fbbfa8299d2bb0f0ee764c5228
https://doi.org/10.1128/aac.9.3.511
https://doi.org/10.1128/aac.9.3.511
Autor:
Cynthia H. O'Callaghan
Publikováno v:
Journal of Antimicrobial Chemotherapy. 5:635-671
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3781652182bdf4d2325f52287ef1b70f
https://doi.org/10.1093/jac/5.6.635
https://doi.org/10.1093/jac/5.6.635
Publikováno v:
Antimicrobial Agents and Chemotherapy. 9:520-525
The pharmacokinetic properties of cefuroxime have been evaluated in laboratory animals. On injection into mice, rats, and rabbits by the subcutaneous or intramuscular routes, high serum level peaks were recorded. There was no significant absorption a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2846bf2ef8cd99ebde580ebcaa559d
https://doi.org/10.1128/aac.9.3.520
https://doi.org/10.1128/aac.9.3.520
Autor:
Monica J. Marshall, Cynthia H. O'Callaghan, G. W. Ross, K. V. Chanter, Anne M. Harris, Susan M. Kirby
Publikováno v:
Analytical Biochemistry. 54:9-16
Two chemical, one physical and two microbiological techniques for the assay of β-lactamase activity have been compared using three partially purified β-lactamases of different specificities. Seven cephalosporins and three penicillins with a wide ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7300d0f4d532130bf1e1db20d8493c94
https://doi.org/10.1016/0003-2697(73)90241-8
https://doi.org/10.1016/0003-2697(73)90241-8
Autor:
Cynthia H. O'Callaghan, A. Morris
Publikováno v:
Antimicrobial Agents and Chemotherapy. 2:442-448
The inhibitory properties of a selected number of β-lactam antibiotics were studied, with the use of three distinct types of β-lactamases. The three enzymes were found to be distinguishable on the basis of their susceptibility to inhibition. Not on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1151462d2da393a1002669f4d5680f1a
https://doi.org/10.1128/aac.2.6.442
https://doi.org/10.1128/aac.2.6.442
Publikováno v:
Journal of Bacteriology. 110:988-991
The hydrolysis of two cephalosporins by three different β-lactamases has been studied. Each enzyme caused a decrease in ultraviolet absorption, a loss of biological activity, and the release of the leaving group from the 3-position. The changes occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac32b6265ffb7ede4d183b302538a28
https://doi.org/10.1128/jb.110.3.988-991.1972
https://doi.org/10.1128/jb.110.3.988-991.1972
Publikováno v:
Journal of Pharmacy and Pharmacology. 23:50-57
Studies of cephalexin in man showed that the conventionally constructed average serum level curves could give misleading results, with the average peak serum level from the curve being lower than the peak titres of the individual curves contributing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b64c8c925bc4352d2531886fd75c223
https://doi.org/10.1111/j.2042-7158.1971.tb12779.x
https://doi.org/10.1111/j.2042-7158.1971.tb12779.x
Autor:
Cynthia H. O'Callaghan
Publikováno v:
Antimicrobial agents and chemotherapy. 13(4)
The chromogenic cephalosporin nitrocefin (87/312) demonstrates rapid and visible instability to serum from many species. This phenomenon was distinct from serum binding, being significantly slower. Destruction of another cephalosporin, 10485, by seru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733720f246aa8dd88612c6a0ac30eb6a
https://pubmed.ncbi.nlm.nih.gov/27139
https://pubmed.ncbi.nlm.nih.gov/27139