Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Cynthia H. Chiu"'
Autor:
Cynthia H. Chiu
Publikováno v:
Current Research in Biotechnology, Vol 5, Iss , Pp 100127- (2023)
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system is a powerful gene editing tool originated from prokaryotes. The modern CRISPR/Cas9 system allows high-throughput genetic screening to be
Externí odkaz:
https://doaj.org/article/8d036eb4908a457e9bf2c17ce938c0bd
Autor:
Jeffrey C. To, Amy P. Chiu, Barbara R. Tschida, Lilian H. Lo, Cynthia H. Chiu, Xiao-Xiao Li, Timothy P. Kuka, Michael A. Linden, Khalid Amin, Wing-Cheung Chan, Jason B. Bell, Branden S. Moriarity, David A. Largaespada, Vincent W. Keng
Publikováno v:
JHEP Reports, Vol 3, Iss 2, Pp 100223- (2021)
Background & Aims: Zinc finger and BTB domain containing 20 (ZBTB20) has been implicated as a potential oncogene in liver cancer. However, knockout studies have shown it to be a transcriptional repressor of the alpha-foetoprotein (Afp) gene in adult
Externí odkaz:
https://doaj.org/article/58dd8d290ff94e908089e3e2954c131c
Publikováno v:
Biochemical and Biophysical Research Communications. 541:70-77
A forward genetic Sleeping Beauty (SB) insertional mutagenesis screen, followed by high-throughput transcriptome sequencing, was used to identify driver genes responsible for hepatocellular carcinoma (HCC)-associated metastasis. Using RNA-sequencing
Autor:
Xiaopeng Bai, Eric X Shi, Kenneth E Lind, Lisa A Marcaurelle, Bing Xia, Vera Q. Bodmer, G Joseph Franklin, Cynthia H. Chiu, LaShadric C. Grady, Eleanor Watts, Jennifer Summerfield, Katie L Sargent Bedard, Xiaojie Lu, Bryan W. King
Publikováno v:
ACS Med Chem Lett
[Image: see text] DNA-encoded library (DEL) technology is a powerful platform for hit identification in academia and the pharmaceutical industry. When conducting off-DNA resynthesis hit confirmation after affinity selection, PCR/sequencing, and data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b32812ada9796c121b40217a07116b2
https://europepmc.org/articles/PMC8274064/
https://europepmc.org/articles/PMC8274064/
Autor:
Xiao Xiao Li, Chi-On Chan, Shi Jie Zhang, Jeffrey C. To, Dewi Kenneth Rowlands, Ka Yi Man, Amy P. Chiu, Daniel K. W. Mok, Cynthia H. Chiu, Vincent W. Keng, Lilian H. Lo
Publikováno v:
Biochemical and biophysical research communications. 531(2)
There is increasing evidence that the sympathetic nervous system (SNS) plays an important role in adipose tissue development. However, the underlying molecular mechanism(s) associated with this remains unclear. SNS innervation of white adipose tissue
Autor:
Robert L. Hale, Sergey N. Krylov, Christopher C. Arico-Muendel, Jiayin Bao, Leonid T. Cherney, Alex Shaginian, Svetlana L. Belyanskaya, Svetlana M. Krylova, Cynthia H. Chiu
Publikováno v:
Analytical Chemistry. 88:5498-5506
Selection of target-binding ligands from DNA-encoded libraries of small molecules (DELSMs) is a rapidly developing approach in drug-lead discovery. Methods of kinetic capillary electrophoresis (KCE) may facilitate highly efficient homogeneous selecti
Autor:
John W. Cuozzo, Cynthia H. Chiu, Barry A. Morgan, Steven R. Skinner, Matthew A. Clark, Jeffrey A. Messer, Yun Ding, Monique F. Murray-Thompson, Rosalie Matico, Christopher C. Arico-Muendel, David I. Israel, Fan Li, Jennifer L. DeLorey, Heather O’Keefe
Publikováno v:
ACS Medicinal Chemistry Letters. 6:888-893
The aggrecan degrading metalloprotease ADAMTS-4 has been identified as a novel therapeutic target for osteoarthritis. Here, we use DNA-encoded Library Technology (ELT) to identify novel ADAMTS-4 inhibitors from a DNA-encoded triazine library by affin
Autor:
Ghotas Evindar, Frank T. Coppo, George P. Vlasuk, Eli Schuman, Charles A. Blum, Cheney Mao, Lei Jin, Han Dai, Robert B. Perni, Jianghe Deng, Svetlana L. Belyanskaya, Todd L. Graybill, John W. Cuozzo, Leah Aquilani, Jeremy S. Disch, Cynthia H. Chiu, Siva Lavu, Kenneth E Lind
Publikováno v:
Journal of Medicinal Chemistry. 56:3666-3679
The sirtuins SIRT1, SIRT2, and SIRT3 are NAD(+) dependent deacetylases that are considered potential targets for metabolic, inflammatory, oncologic, and neurodegenerative disorders. Encoded library technology (ELT) was used to affinity screen a 1.2 m
Autor:
Malcolm L. Gefter, Alexander L. Satz, Matthew C Oliff, Cecil E Rise, Sibongile Mataruse, Fan Li, Cynthia H. Chiu, John W. Cuozzo, Steven R. Skinner, Matthew A. Clark, Gang Yao, Kurt D Franzen, Paul Myers, Heather O’Keefe, Lujia Tang, Christopher S. Kollmann, Christopher P. Davie, Nils Jakob Vest Hansen, Neil R Carlson, Paolo A. Centrella, Michael Kelley, Patricia F Medeiros, Steven P Hale, Richard W. Wagner, Christopher C. Arico-Muendel, Dennis Benjamin, David I. Israel, Kurt van Vloten, G Joseph Franklin, Svetlana L. Belyanskaya, Jennifer L Svendsen, Kenneth E Lind, Raksha A. Acharya, Barry A. Morgan, Baoguang Zhao, Steffen Phillip Creaser, Malcolm J. Kavarana, Jinwei Jiang, Jeffrey A. Messer, Yun Ding
Publikováno v:
Nature Chemical Biology. 5:647-654
Biochemical combinatorial techniques such as phage display, RNA display and oligonucleotide aptamers have proven to be reliable methods for generation of ligands to protein targets. Adapting these techniques to small synthetic molecules has been a lo
Autor:
Robert L. Hale, Svetlana M. Krylova, Sergey N. Krylov, Leonid T. Cherney, Cynthia H. Chiu, Christopher C. Arico-Muendel, Jiayin Bao, Svetlana L. Belyanskaya
Publikováno v:
Analytical chemistry. 87(4)
Selection of protein binders from highly diverse combinatorial libraries of DNA-encoded small molecules is a highly promising approach for discovery of small-molecule drug leads. Methods of kinetic capillary electrophoresis provide the high efficienc