Anti-inflammatory and anticancer effects of flavonol glycosides from Diplotaxis harra through GSK3β regulation in intestinal cells

Autor: Imen Nasri, Rachid Chawech, Cynthia Girardi, Emmanuel Mas, Audrey Ferrand, Nathalie Vergnolle, Nicolas Fabre, Raoudha Mezghani-Jarraya, Claire Racaud-Sultan

Publikováno v: Pharmaceutical Biology, Vol 55, Iss 1, Pp 124-131 (2017)

Context and objective: Diplotaxis harra (Forssk.) Boiss. (Brassicaceae) is traditionally used as an antidiabetic, anti-inflammatory or anticancer agent. In these pathologies, the glycogen synthase kinase 3 β (GSK3β) is overactivated and represents

Externí odkaz: https://doaj.org/article/b9fe10d7fb48493ba4c8d8d34964879a

Macrocyclic Spermidine Alkaloids from Androya decaryi L. Perrier

Autor: Claude Moulis, Nicolas Fabre, Alexis Valentin, Cynthia Girardi, Sonia Mallet-Ladeira, Nehal Ibrahim, Frédéric Manjary, Anne-Cécile Le Lamer

Publikováno v: Molecules, Vol 18, Iss 4, Pp 3962-3971 (2013)

Three new spermidine alkaloids and two known compounds were isolated from the leaves of Androya decaryi. Their structures were elucidated on the basis of their spectroscopic data (NMR and mass spectrometry), by X-Ray diffraction and by comparison wit

Externí odkaz: https://doaj.org/article/f2cd6a88c0374e18b477564bb1eeec39

Design, Synthesis and Biological Activity of C3 Hemisynthetic Triterpenic Esters as Novel Antitrypanosomal Hits

Autor: Jorge Alejandro Palermo, Cynthia Girardi, Joëlle Quetin-Leclercq, Aurélie Leverrier, Laura Schioppa, Claire Beaufay, Jacques H. Poupaert, Sergio Ortiz, Marianela Sánchez, Natacha Bonneau

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
ChemistryOpen, Vol 10, Iss 9, Pp 896-903 (2021)
ChemistryOpen

Research for innovative drugs is crucial to contribute to parasitic infections control and eradication. Inspired by natural antiprotozoal triterpenes, a library of 12 hemisynthetic 3‐O‐arylalkyl esters was derived from ursolic and oleanolic acids

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eeb7cd7e3f8c01b3ad6566b1037694e
https://doi.org/10.1002/open.202100159

Anti-inflammatory and anticancer effects of flavonol glycosides from Diplotaxis harra through GSK3β regulation in intestinal cells

Autor: Raoudha Mezghani-Jarraya, Cynthia Girardi, Rachid Chawech, Nicolas Fabre, Imen Nasri, Audrey Ferrand, Emmanuel Mas, Nathalie Vergnolle, Claire Racaud-Sultan

Publikováno v: Pharmaceutical Biology
Pharmaceutical Biology, Taylor & Francis, 2017, 55 (1), pp.124-131. ⟨10.1080/13880209.2016.1230877⟩
Pharmaceutical Biology 1 (55), 124-131. (2017)
Pharmaceutical Biology, Vol 55, Iss 1, Pp 124-131 (2017)
Pharmaceutical biology
Pharmaceutical biology, 2017, 55 (1), pp.124-131. ⟨10.1080/13880209.2016.1230877⟩

International audience; Context and objective: Diplotaxis harra (Forssk.) Boiss. (Brassicaceae) is traditionally used as an antidiabetic, anti-inflammatory or anticancer agent. In these pathologies, the glycogen synthase kinase 3 b (GSK3b) is overact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3938b9de3b05d58dc9293bb126f93ea7
https://doi.org/10.1080/13880209.2016.1230877

Analysis and fragmentation mechanisms of hirsutinolide-type sesquiterpene lactones by ultra-high-performance liquid chromatography/electrospray ionization linear ion trap Orbitrap mass spectrometry

Autor: Cynthia, Girardi, Valérie, Jullian, Mohamed, Haddad, Marieke, Vansteelandt, Billy Joel, Cabanillas, Coco N, Kapanda, Marie-France, Herent, Joëlle, Quetin-Leclercq, Nicolas, Fabre

Publikováno v: Rapid communications in mass spectrometry : RCM. 30(5)

Hirsutinolide-type sesquiterpene lactones (SLs) are natural biologically active compounds mainly found in the genus Vernonia. Very few studies have been published about the fragmentation mechanisms of SLs generally and none about hirsutinolides, alth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae02aa786c73dda77348a1551b5a826d
https://pubmed.ncbi.nlm.nih.gov/26842579