Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Cynthia G. Sawyez"'
Autor:
Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Marisa R. Morrow, Cynthia G. Sawyez, Jane Y. Edwards, Maria Drangova, Murray W. Huff
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1714-1728 (2018)
Obesity and its associated metabolic dysfunction and cardiovascular disease risk represent a leading cause of adult morbidity worldwide. Currently available pharmacological therapies for obesity have had limited success in reversing existing obesity
Externí odkaz:
https://doaj.org/article/761ce2d5872b400187ff5a277fcec253
Publikováno v:
Data in Brief, Vol 10, Iss C, Pp 385-389 (2017)
As nonalcoholic fatty liver disease progresses to end-stage diseases, including fibrosis, cirrhosis and hepatocellular carcinoma, fibrotic activated hepatic stellate cells and cancerous epithelial cells can become abundant, changing the cellular comp
Externí odkaz:
https://doaj.org/article/84ccc6e8b43c4cf88e18cdc907383f44
Autor:
Alexandra M. Hetherington, Cynthia G. Sawyez, Emma Zilberman, Alexandra M. Stoianov, Debra L. Robson, Nica M. Borradaile
Publikováno v:
Cellular Physiology and Biochemistry, Vol 39, Iss 4, Pp 1648-1662 (2016)
Background/Aims: Nonalcoholic fatty liver disease (NAFLD) progression to fibrosis, cirrhosis and hepatocellular carcinoma, alters the cellular composition of this organ. During late-stage NAFLD, fibrotic and possibly cancerous cells can proliferate a
Externí odkaz:
https://doaj.org/article/b1356ecf499f4b52921152aac4bb28de
Autor:
Lazar A. Bojic, Dawn E. Telford, Morgan D. Fullerton, Rebecca J. Ford, Brian G. Sutherland, Jane Y. Edwards, Cynthia G. Sawyez, Robert Gros, Bruce E. Kemp, Gregory R. Steinberg, Murray W. Huff
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 7, Pp 1254-1266 (2014)
PPARδ regulates systemic lipid homeostasis and inflammation, but its role in hepatic lipid metabolism remains unclear. Here, we examine whether intervening with a selective PPARδ agonist corrects hepatic steatosis induced by a high-fat, cholesterol
Externí odkaz:
https://doaj.org/article/02e95e718419411d991a2cb2fb2378cb
Autor:
Julia M. Assini, Erin E. Mulvihill, Brian G. Sutherland, Dawn E. Telford, Cynthia G. Sawyez, Sarah L. Felder, Sanjiv Chhoker, Jane Y. Edwards, Robert Gros, Murray W. Huff
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 3, Pp 711-724 (2013)
Obesity-associated chronic inflammation contributes to metabolic dysfunction and propagates atherosclerosis. Recent evidence suggests that increased dietary cholesterol exacerbates inflammation in adipose tissue and liver, contributing to the proathe
Externí odkaz:
https://doaj.org/article/158247674e644e5aa756021704b6e7ce
Autor:
Stewart C. Whitman, Carmen A. Argmann, Cynthia G. Sawyez, David B. Miller, Robert A. Hegele, Murray W. Huff
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 6, Pp 1017-1028 (1999)
Hypertriglyceridemic (HTG) very low density lipoproteins (VLDL) from subjects with type IV hyperlipoproteinemia induce both cholesteryl ester (CE) and triglyceride (TG) accumulation in cultured J774 macrophages. We examined whether the cytokine inter
Externí odkaz:
https://doaj.org/article/612917d74fa4488d9d6051e74503c46d
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 5, Pp 1008-1020 (1998)
We have previously shown that very low density lipoproteins (VLDL, Sf 60–400) from subjects with type IV hyperlipoproteinemia (HTG-VLDL) will induce appreciable cholesteryl ester accumulation in cultured macrophages (J774A.1). The present study exa
Externí odkaz:
https://doaj.org/article/681c91d0d4234083a4a967b64cadec0c
Autor:
Zengxuan Nong, Rachel B. Wilson, J. Geoffrey Pickering, Hao Yin, Chanho Park, Kia M. Peters, Richard Zhang, Cynthia G. Sawyez, Brian G. Sutherland, Nica M. Borradaile
Publikováno v:
The Journal of Nutritional Biochemistry. 70:65-74
Vitamin D appears to either promote or inhibit neovascularization in a disease context-dependent manner. The effects of vitamin D, alone or in combination with niacin, on endothelial cell (EC) angiogenic function and on revascularization in obese ani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca08e42741e2e7b3a22b302bf7081597
https://doi.org/10.1016/j.jnutbio.2019.04.010
https://doi.org/10.1016/j.jnutbio.2019.04.010
Autor:
Marisa R. Morrow, Brian G. Sutherland, Jane Y. Edwards, Dawn E. Telford, Amy C. Burke, Maria Drangova, Cynthia G. Sawyez, Murray W. Huff
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1714-1728 (2018)
Medical Biophysics Publications
Bone and Joint Institute
Medical Biophysics Publications
Bone and Joint Institute
Copyright © 2018 Burke et al. Obesity and its associated metabolic dysfunction and cardiovascular disease risk represent a leading cause of adult morbidity worldwide. Currently available pharmacological therapies for obesity have had limited success
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f221864abbec4ab66bd0eb13e40524dd
http://www.sciencedirect.com/science/article/pii/S0022227520335409
http://www.sciencedirect.com/science/article/pii/S0022227520335409
Autor:
Jane Y. Edwards, J. Geoffrey Pickering, Brian G. Sutherland, Cynthia G. Sawyez, Amy C. Burke, Murray W. Huff, Dawn E. Telford, P. Hugh R. Barrett, Roger S. Newton
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38:1178-1190
Objective— Bempedoic acid (BemA; ETC-1002) is a novel drug that targets hepatic ATP-citrate lyase to reduce cholesterol biosynthesis. In phase 2 studies, BemA lowers elevated low-density lipoprotein cholesterol (LDL-C) in hypercholesterolemic patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d464461bfa4ff8f963650f27381fecd7
https://doi.org/10.1161/atvbaha.117.310676
https://doi.org/10.1161/atvbaha.117.310676