Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Cynthia D. Sobotka-Briner"'
Autor:
Gaochao Tian, Barry D. Greenberg, Cynthia D. Sobotka-Briner, Smita V. Ghanekar, Clay W Scott, Xiaomei Ye, Katharine S. Knappenberger
Publikováno v:
Biochemistry. 43:6208-6218
Maturation of gamma-secretase requires an endoproteolytic cleavage in presenilin-1 (PS1) within a peptide loop encoded by exon 9 of the corresponding gene. Deletion of the loop has been demonstrated to cause familial Alzheimer's disease. A synthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3fa07fe56c84be2f1de68a2fe273ce
https://doi.org/10.1021/bi036072v
https://doi.org/10.1021/bi036072v
Autor:
Cynthia D. Sobotka-Briner, William Potts, Becky Brockel, M. Edward Pierson, Ashok B. Shenvi, Donna L. Maier, Diansong Zhou, Dan Widzowski, Minli Zhang, Yi Wang, Bernstein Peter Robert
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 339(2)
The preclinical pharmacology and pharmacokinetic properties of (2R)-6-methoxy-8-(4-methylpiperazin-1-yl)-N-(4-morpholin-4-ylphenyl)chromane-2-carboxamide (AZD3783), a potent 5-hydroxytryptamine 1B (5-HT(1B)) receptor antagonist, were characterized as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba093060a540563c94fb68faabf2259
https://pubmed.ncbi.nlm.nih.gov/21825000
https://pubmed.ncbi.nlm.nih.gov/21825000
Autor:
Jianwei Liu, Jennifer R. Krumrine, Bernstein Peter Robert, Nugiel David, Daniel Hill, Cynthia D. Sobotka-Briner, Anna Zacco, M. Edward Pierson, James R. Damewood
Publikováno v:
Journal of medicinal chemistry. 53(4)
We describe herein the discovery of novel, de novo designed, 5-HT(1B) receptor antagonists that lack a basic moiety and that provide improved hERG and in vitro phospholipidosis profiles. We used a known 5-HT(1B) antagonist template as our starting po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8626434df01fa83289d48300b27136f
https://pubmed.ncbi.nlm.nih.gov/20088516
https://pubmed.ncbi.nlm.nih.gov/20088516
Autor:
Phil Edwards, Cynthia Birr, Cynthia D. Sobotka-Briner, Gaochao Tian, Barry D. Greenberg, John R. Zysk, Clay W Scott, Mark Sylvester, Xiaodong Liu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52eddaf724c93ce04fad97b80304643e
https://europepmc.org/articles/PMC6741744/
https://europepmc.org/articles/PMC6741744/
Autor:
Gaochao Tian, Xiaodong Liu, Clay D. Scott, Cynthia Birr, Cynthia D. Sobotka-Briner, Philip D. Edwards, Barry D. Greenberg, John R. Zysk, Mark Sylvester
Publikováno v:
The Journal of biological chemistry. 277(35)
Cerebral deposition of amyloid beta-protein (A beta) is believed to play a key role in the pathogenesis of Alzheimer's disease. Because A beta is produced from the processing of amyloid beta-protein precursor (APP) by beta- and gamma-secretases, thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f485c10bf6147756d3b50ebecf68cf
https://pubmed.ncbi.nlm.nih.gov/12072428
https://pubmed.ncbi.nlm.nih.gov/12072428