Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Cynthia D, Guy"'
Autor:
William A. Murphy, Anna Mae Diehl, Matthew Shane Loop, Dong Fu, Cynthia D. Guy, Manal F. Abdelmalek, Georgia Sofia Karachaliou, Noora Sjöstedt, Sibylle Neuhoff, Paavo Honkakoski, Kim L. R. Brouwer
Publikováno v:
Hepatology Communications, Vol 8, Iss 3 (2024)
Background:. NAFLD is highly prevalent with limited treatment options. Bile acids (BAs) increase in the systemic circulation and liver during NAFLD progression. Changes in plasma membrane localization and zonal distribution of BA transporters can inf
Externí odkaz:
https://doaj.org/article/aac573e3c0734319af4532863a1f9a55
Autor:
Mary E. Rinella, Jeffrey V. Lazarus, Vlad Ratziu, Sven M. Francque, Arun J. Sanyal, Fasiha Kanwal, Diana Romero, Manal F. Abdelmalek, Quentin M. Anstee, Juan Pablo Arab, Marco Arrese, Ramon Bataller, Ulrich Beuers, Jerome Boursier, Elisabetta Bugianesi, Christopher D. Byrne, Graciela E. Castro Narro, Abhijit Chowdhury, Helena Cortez-Pinto, Donna R. Cryer, Kenneth Cusi, Mohamed El-Kassas, Samuel Klein, Wayne Eskridge, Jiangao Fan, Samer Gawrieh, Cynthia D. Guy, Stephen A. Harrison, Seung Up Kim, Bart G. Koot, Marko Korenjak, Kris V. Kowdley, Florence Lacaille, Rohit Loomba, Robert Mitchell-Thain, Timothy R. Morgan, Elisabeth E. Powell, Michael Roden, Manuel Romero-Gómez, Marcelo Silva, Shivaram Prasad Singh, Silvia C. Sookoian, C. Wendy Spearman, Dina Tiniakos, Luca Valenti, Miriam B. Vos, Vincent Wai-Sun Wong, Stavra Xanthakos, Yusuf Yilmaz, Zobair Younossi, Ansley Hobbs, Marcela Villota-Rivas, Philip N. Newsome
Publikováno v:
Annals of Hepatology, Vol 29, Iss 1, Pp 101133- (2024)
The principal limitations of the terms NAFLD and NASH are the reliance on exclusionary confounder terms and the use of potentially stigmatising language. This study set out to determine if content experts and patient advocates were in favor of a chan
Externí odkaz:
https://doaj.org/article/f02c612b79da4aaa8837228f72393227
Autor:
Ryan M. Gill, Daniela Allende, Patricia H. Belt, Cynthia A. Behling, Oscar W. Cummings, Cynthia D. Guy, Daniela Carpenter, Brent A. Neuschwander-Tetri, Arun J. Sanyal, James Tonascia, Mark L. Van Natta, Laura A. Wilson, Goro Yamada, Matthew Yeh, David E. Kleiner, for the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)
Publikováno v:
Hepatology Communications, Vol 7, Iss 2, Pp e0033-e0033 (2023)
Background and Aims:. The NAFLD activity score was developed to measure histologic changes in NAFLD during therapeutic trials. Hepatocyte ballooning (HB) is the most specific feature in steatohepatitis diagnosis, yet the impact of variations in HB ha
Externí odkaz:
https://doaj.org/article/e064dc2fe4194521b39689b3632131c5
Autor:
Oliver Glass, Daniel Liu, Elizabeth Bechard, Cynthia D. Guy, Jane Pendergast, Anna Mae Diehl, Manal F. Abdelmalek
Publikováno v:
Hepatology Communications, Vol 6, Iss 2, Pp 334-344 (2022)
Exercise is a foundational treatment for nonalcoholic fatty liver disease (NAFLD); however, the majority of patients are unable to initiate and maintain effective exercise habits and remain at increased risk for progressive liver disease. Barriers an
Externí odkaz:
https://doaj.org/article/0754ff572f954669987544ab843d6327
Autor:
Samuel J. Kesseli, Jared N. Gloria, Nader Abraham, Samantha E. Halpern, Greta N. Cywinska, Min Zhang, Dimitrios Moris, Robin Schmitz, Brian I. Shaw, Zachary W. Fitch, Mingqing Song, Cynthia D. Guy, Mathew G Hartwig, Stuart Knechtle, Andrew S. Barbas
Publikováno v:
Hepatology Communications, Vol 5, Iss 9, Pp 1527-1542 (2021)
Normothermic machine perfusion (NMP) provides clinicians an opportunity to assess marginal livers before transplantation. However, objective criteria and point‐of‐care (POC) biomarkers to predict risk and guide decision making are lacking. In thi
Externí odkaz:
https://doaj.org/article/d2501de6355e401196796b4e7d412c7c
Sex and Menopause Modify the Effect of Single Nucleotide Polymorphism Genotypes on Fibrosis in NAFLD
Autor:
Kara Wegermann, Melanie E. Garrett, Jiayin Zheng, Andrea Coviello, Cynthia A. Moylan, Manal F. Abdelmalek, Shein‐Chung Chow, Cynthia D. Guy, Anna Mae Diehl, Allison Ashley‐Koch, Ayako Suzuki
Publikováno v:
Hepatology Communications, Vol 5, Iss 4, Pp 598-607 (2021)
The development of fibrosis in nonalcoholic fatty liver disease (NAFLD) is influenced by genetics, sex, and menopausal status, but whether genetic susceptibility to fibrosis is influenced by sex and reproductive status is unclear. Our aim was to iden
Externí odkaz:
https://doaj.org/article/b7925e634c3749e48299369bbda597e9
Autor:
Kara Wegermann, Catherine Howe, Ricardo Henao, Ying Wang, Cynthia D. Guy, Manal F. Abdelmalek, Anna Mae Diehl, Cynthia A. Moylan
Publikováno v:
Hepatology Communications, Vol 5, Iss 4, Pp 608-617 (2021)
Identifying patients at higher risk for poor outcomes from nonalcoholic fatty liver disease (NAFLD) remains challenging. Metabolomics, the comprehensive measurement of small molecules in biological samples, has the potential to reveal novel noninvasi
Externí odkaz:
https://doaj.org/article/8827ebe784e343ad945032872f158e20
Autor:
Timothy A. Dinh, Mark L. Jewell, Matt Kanke, Adam Francisco, Ramja Sritharan, Rigney E. Turnham, Seona Lee, Edward R. Kastenhuber, Eliane Wauthier, Cynthia D. Guy, Raymond S. Yeung, Scott W. Lowe, Lola M. Reid, John D. Scott, Anna M. Diehl, Praveen Sethupathy
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 803-817 (2019)
Background & Aims: Fibrolamellar carcinoma (FLC) is a rare liver cancer that primarily affects adolescents and young adults. It is characterized by a heterozygous approximately 400-kb deletion on chromosome 19 that results in a unique fusion between
Externí odkaz:
https://doaj.org/article/7c0b575b397444a8aec84eb5e9313d8a
Autor:
Oliver Glass, Ricardo Henao, Keyur Patel, Cynthia D. Guy, Hans J. Gruss, Wing‐Kin Syn, Cynthia A. Moylan, Robert Streilein, Russell Hall, Anna Mae Diehl, Manal F. Abdelmalek
Publikováno v:
Hepatology Communications, Vol 2, Iss 11, Pp 1344-1355 (2018)
The severity of hepatic fibrosis is the primary predictor of liver‐related morbidity and mortality in patients with nonalcoholic fatty liver disease (NAFLD). Unfortunately, noninvasive serum biomarkers for NAFLD‐associated fibrosis are limited. W
Externí odkaz:
https://doaj.org/article/15c5b601b1564633b905485bbd685159
Autor:
Sarah E. Kleinstein, Matthew Rein, Manal F. Abdelmalek, Cynthia D. Guy, David B. Goldstein, Anna Mae Diehl, Cynthia A. Moylan
Publikováno v:
Hepatology Communications, Vol 2, Iss 9, Pp 1021-1029 (2018)
Abstract Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous disease with highly variable outcomes. Patients with simple steatosis typically experience a benign course, whereas those with more advanced liver injury, nonalcoholic steatohepatit
Externí odkaz:
https://doaj.org/article/2a83b6bb981c4ad98bdc25157f8217b4