Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Cynthia Czajkowski"'
Autor:
Cosma D Dellisanti, Borna Ghosh, Susan M Hanson, James M Raspanti, Valerie A Grant, Gaoussou M Diarra, Abby M Schuh, Kenneth Satyshur, Candice S Klug, Cynthia Czajkowski
Publikováno v:
PLoS Biology, Vol 11, Iss 11, p e1001714 (2013)
Pentameric ligand-gated ion channels (pLGICs) are neurotransmitter-activated receptors that mediate fast synaptic transmission. In pLGICs, binding of agonist to the extracellular domain triggers a structural rearrangement that leads to the opening of
Externí odkaz:
https://doaj.org/article/62261114edfa4489ac66c27346e0b4f7
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80322 (2013)
Electrochemical signaling in the brain depends on pentameric ligand-gated ion channels (pLGICs). Recently, crystal structures of prokaryotic pLGIC homologues from Erwinia chrysanthemi (ELIC) and Gloeobacter violaceus (GLIC) in presumed closed and ope
Externí odkaz:
https://doaj.org/article/720ff4c233e541b585e52075a56f2828
Autor:
Swetha K. Godavarthi, Masaki Hiramoto, Yuri Ignatyev, Jacqueline B. Levin, Hui-quan Li, Marta Pratelli, Jennifer Borchardt, Cynthia Czajkowski, Laura N. Borodinsky, Lora Sweeney, Hollis T. Cline, Nicholas C. Spitzer
Stable matching of neurotransmitters with their receptors is fundamental to synapse function, to achieve reliable and robust communication in neural circuits. Presynaptic neurotransmitters regulate selection of postsynaptic transmitter receptors. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20a3f9e8b7b6963e329b3a373fb2477f
https://doi.org/10.1101/2022.09.10.507343
https://doi.org/10.1101/2022.09.10.507343
Publikováno v:
Biophysical Journal. 122:393a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6970b515b0d5e25f2c34f8eb78f70d10
https://doi.org/10.1016/j.bpj.2022.11.2148
https://doi.org/10.1016/j.bpj.2022.11.2148
Publikováno v:
Biophysical Journal. 122:459a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d297884ccd3f731adc7464cae2eaf319
https://doi.org/10.1016/j.bpj.2022.11.2467
https://doi.org/10.1016/j.bpj.2022.11.2467
First synthesized in the 1950s, benzodiazepines are widely prescribed drugs that exert their anxiolytic, sedative and anticonvulsant actions by binding to GABA-A receptors, the main inhibitory ligand-gated ion channel in the brain. Scientists have lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b12d3610ac6980e8d2bcde81ed67df24
https://doi.org/10.1101/2021.08.13.456294
https://doi.org/10.1101/2021.08.13.456294
Signaling in the brain depends on rapid opening and closing of pentameric ligand-gated ion channels (pLGICs). These proteins are the targets of various clinical drugs and, defects in their function is linked to a variety of diseases including myasthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85354bf1bde18792a6e201f24c0def96
https://doi.org/10.1101/2020.11.04.368233
https://doi.org/10.1101/2020.11.04.368233
Publikováno v:
Biophysical Journal. 121:383a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29f73ab536b44f6034b40325e7101fd9
https://doi.org/10.1016/j.bpj.2021.11.843
https://doi.org/10.1016/j.bpj.2021.11.843
Publikováno v:
Neuropharmacology. 125:343-352
Pentameric ligand-gated ion channels (pLGICs) are the targets of several clinical and endogenous allosteric modulators including anesthetics and neurosteroids. Molecular mechanisms underlying allosteric drug modulation are poorly understood. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f2a37e7ef11c93836de6378bec1b5e
https://doi.org/10.1016/j.neuropharm.2017.08.007
https://doi.org/10.1016/j.neuropharm.2017.08.007