Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Cynthia Cienfuegos"'
Autor:
Andrew T Miller, Carol Dahlberg, Mark L Sandberg, Ben G Wen, Daniel R Beisner, John A H Hoerter, Albert Parker, Christian Schmedt, Monique Stinson, Jacqueline Avis, Cynthia Cienfuegos, Mark McPate, Pamela Tranter, Martin Gosling, Paul J Groot-Kormelink, Janet Dawson, Shifeng Pan, Shin-Shay Tian, H Martin Seidel, Michael P Cooke
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131071 (2015)
Emerging approaches to treat immune disorders target positive regulatory kinases downstream of antigen receptors with small molecule inhibitors. Here we provide evidence for an alternative approach in which inhibition of the negative regulatory inosi
Externí odkaz:
https://doaj.org/article/60911ac9821349a2a5779985bf95458d
Autor:
Jacqueline Avis, Sinead M. Clancy, Jeffrey L. Noebels, Truc Hunyh, Christian Schmedt, Federica Bertaso, Karsten Baumgärtel, Cynthia Cienfuegos, Xiaofei Zhang, Timothy Jegla, Carly Wilmot, Van Lee, Jong W. Yoo, Catherine Daguia
Publikováno v:
Nature neuroscience
We found the voltage-gated K+ channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons. Kv12.2-/- (also kn
Autor:
Jacqueline Avis, Janet Dawson, Paul J. Groot-Kormelink, Albert E. Parker, Shifeng Pan, Mark L. Sandberg, Ben G. Wen, Andrew T. Miller, Cynthia Cienfuegos, H. Martin Seidel, Monique Stinson, Daniel R. Beisner, John A. H. Hoerter, Michael P. Cooke, Shin-Shay Tian, Pamela Tranter, Martin Gosling, Christian Schmedt, Mark McPate, Carol Dahlberg
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 6, p e0131071 (2015)
PLoS ONE, Vol 10, Iss 6, p e0131071 (2015)
Emerging approaches to treat immune disorders target positive regulatory kinases downstream of antigen receptors with small molecule inhibitors. Here we provide evidence for an alternative approach in which inhibition of the negative regulatory inosi