Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Cynthia Brimer"'
Autor:
Satyanarayana R. Pondugula, Taosheng Chen, Erin G. Schuetz, Cynthia Brimer-Cline, Rakesh K. Tyagi, Jing Wu
Publikováno v:
Drug Metabolism and Disposition. 37:719-730
The pregnane X receptor (PXR) plays crucial roles in multiple physiological processes. However, the signaling mechanisms responsible are not well defined; it is most likely that multiple functions of PXR are modulated by its phosphorylation. Therefor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a29a55f0e815d1dab4709b73b11104
https://doi.org/10.1124/dmd.108.024695
https://doi.org/10.1124/dmd.108.024695
Autor:
Steven A. Wrighton, Patrick Maurel, Mark S. Boguski, Cynthia Brimer, John D. Schuetz, Stephen D. Hall, Kenneth E. Thummel, Mary V. Relling, Mahfoud Assem, Raman Venkataramanan, Jatinder K. Lamba, Paul B. Watkins, Stephen C. Strom, Erin G. Schuetz, Ann K. Daly, Kazuto Yasuda, Jiong Zhang, Yvonne S. Lin, Peter M. Kuehl
Publikováno v:
Nature Genetics. 27:383-391
Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating steroid levels and responses to half of all oxidatively metabolized drugs. CYP3A activity is the sum activity of the family of CYP3A genes, including CYP3A5, which i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a869d1677b5c8b33e8eb1517675b671c
https://doi.org/10.1038/86882
https://doi.org/10.1038/86882
Autor:
Elio F. Vanin, John D. Schuetz, Erin G. Schuetz, Yi Lu, Zixin Zhu, Mary V. Relling, James T. Dalton, Kazuto Yasuda, Cynthia Brimer
Publikováno v:
Pharmaceutical Research. 17:803-810
Purpose. To develop model polarized cell systems expressingcytochrome P4503A4, NADPH P450 reductase, and P-glycoprotein (Pgp). Methods. LLC-PK1 and derivative L-MDR1 cells stably expressing Pgp,the product of the multidrug resistance gene (MDR1), wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1076052a1068508d7ea6dedda81d6132
https://doi.org/10.1023/a:1007599923694
https://doi.org/10.1023/a:1007599923694
Publikováno v:
Molecular Pharmacology. 54:1113-1117
The pregnenolone X receptor (PXR), a new member of the nuclear hormone receptor superfamily, was recently demonstrated to mediate glucocorticoid agonist and antagonist activation of a hormone response element spaced by three nucleotides (DR-3) within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6644f2950f4da2f5d7be4b16b79fcea
https://doi.org/10.1124/mol.54.6.1113
https://doi.org/10.1124/mol.54.6.1113
Autor:
Philippe Gambert, Mahfoud Assem, David Masson, Laurent Lagrost, Erin G. Schuetz, John D. Schuetz, Anne Athias, Cynthia Brimer-Cline, Lu-Bin Lan
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 25(10)
Objective— Modification of lipoprotein metabolism by bile acids has been mainly explained by activation of the farnesyl X receptor (FXR). The aim of the present study was to determine the relative contribution of the pregnane X receptor (PXR), anot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6229a6da5f566e64f43db4233a33d5
https://pubmed.ncbi.nlm.nih.gov/16199756
https://pubmed.ncbi.nlm.nih.gov/16199756
Autor:
C. H. Pui, W. Yang, Soma Das, Y. Lin, Steven A. Wrighton, L. Fan, Cynthia Brimer, J. Y. Guo, Michael D. Amylon, Bruce M. Camitta, Mahfoud Assem, Ann K. Daly, Javier G. Blanco, J. Zhang, S. C. Lee, Jatinder K. Lamba, S. Kishi, L. Z. Wang, Erin G. Schuetz, A. B. Ong, Naomi J. Winick, Kenneth E. Thummel, Peter M. Kuehl, Patrick Maurel, Thierry Dervieux, R. Lim, Frederick G. Behm, M. V. Relling, B. C. Goh, John D. Schuetz, Mark S. Boguski, Edwin H. Cook, Gary L. Rosner, Stephen C. Strom, P. Chen, Paul B. Watkins, H. L. Lim, Michael L. Hancock, Stephen D. Hall, Robert O. Bash, Raman Venkataramanan, Kazuto Yasuda, Mathew J. Edick, H. S. Lee, Susana C. Raimondi
Publikováno v:
Scopus-Elsevier
Category: Genotype PharmGKB Submission Numbers: PS113737, PS115406, PS114503, PS200420, PS201057, PS115245 Date of Submission: May 19, 2003 Project: Pharmacogenetics of Anticancer Agents, St. Jude Children's Research Hospital HGNC Symbol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de5eb0d861d2eb8c7f81e761ad1df14
https://pubmed.ncbi.nlm.nih.gov/15169924
https://pubmed.ncbi.nlm.nih.gov/15169924
Autor:
Cynthia, Brimer-Cline, Erin G, Schuetz
Publikováno v:
Methods in enzymology. 357
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::81bef2031e5c9440f2a5b29141399402
https://pubmed.ncbi.nlm.nih.gov/12424922
https://pubmed.ncbi.nlm.nih.gov/12424922
Autor:
Evan D. Kharasch, Tauri Senn, Kazuto Yasuda, Erin G. Schuetz, Hitoshi Ishizuka, Kenneth E. Thummel, Cynthia Brimer, John D. Schuetz, Jaideep V. Thottassery, Yvonne S. Lin
Publikováno v:
Molecular pharmacology. 60(6)
It was previously shown that CYP3A4 is induced in the human intestinal Caco-2 cell model by treatment with 1alpha,25-dihydroxy vitamin D3 (1,25-D3). We demonstrate the vitamin D analog, 19-nor-1alpha,25-dihydroxy vitamin D2, is also an effective indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45c1ce18da55724b20a533db242d510
https://pubmed.ncbi.nlm.nih.gov/11723248
https://pubmed.ncbi.nlm.nih.gov/11723248
Autor:
Richard B. Kim, Steven A. Wrighton, Jeffery W. Touchman, Ann K. Daly, Eric D. Green, Paul B. Watkins, Erin G. Schuetz, Stephen C. Strom, Patrick Maurel, Mark S. Boguski, Kenneth E. Thummel, Kazuto Yasuda, Cynthia Brimer, Christopher G. Russell, Michael L. Hancock, Stephen D. Hall, M. V. Relling, Jiong Zhang, Peter M. Kuehl, James R. Hudson
Publikováno v:
Pharmacogenetics. 11(7)
The pregnane X receptor (PXR)/steroid and xenobiotic receptor (SXR) transcriptionally activates cytochrome P4503A4 (CYP3A4) when ligand activated by endobiotics and xenobiotics. We cloned the human PXR gene and analysed the sequence in DNAs of indivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89069e6eec1265e28b2d6bb0bd38fd19
https://pubmed.ncbi.nlm.nih.gov/11668214
https://pubmed.ncbi.nlm.nih.gov/11668214
Autor:
Erin G. Schuetz, Jatinder K. Lamba, John D. Schuetz, Frank J. Gonzalez, Richard B. Kim, Raman Venkataramanan, Cynthia Brimer, Stephen C. Strom, Valerie Lecureur, Christopher J. Sinal, Hongbo Cai, Mahfoud Assem, Kazuto Yasuda, Vinod Ramachandran, Bernard J. Komoroski
Publikováno v:
The Journal of biological chemistry. 276(42)
Sister of P-glycoprotein (SPGP) is the major hepatic bile salt export pump (BSEP). BSEP/SPGP expression varies dramatically among human livers. The potency and hierarchy of bile acids as ligands for the farnesyl/bile acid receptor (FXR/BAR) parallele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126ef76c1dac732d2664f143ad5d1fb3
https://pubmed.ncbi.nlm.nih.gov/11509573
https://pubmed.ncbi.nlm.nih.gov/11509573