Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Cynthia Bleiwas"'
Autor:
Ying Jiang, John J. Alam, Stephen N. Gomperts, Paul Maruff, Afina W. Lemstra, Ursula A. Germann, Philip H. Stavrides, Sandipkumar Darji, Sandeep Malampati, James Peddy, Cynthia Bleiwas, Monika Pawlik, Anna Pensalfini, Dun-Sheng Yang, Shivakumar Subbanna, Balapal S. Basavarajappa, John F. Smiley, Amanda Gardner, Kelly Blackburn, Hui-May Chu, Niels D. Prins, Charlotte E. Teunissen, John E. Harrison, Philip Scheltens, Ralph A. Nixon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors show in an animal model and in a study in patients with dementia with Lewy bodies (DLB) that the drug neflamapimod has potential to treat diseases, such as DLB, associated with loss of neurons that produce the neurotransmitter acetylcholi
Externí odkaz:
https://doaj.org/article/435994d00b734e18a90ea82931cd1bac
Autor:
John F. Smiley, Cynthia Bleiwas, Brandon M. Marino, Prerana Vaddi, Stefanie Canals-Baker, Donald A. Wilson, Mariko Saito
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
In neonatal brain development there is a period of normal apoptotic cell death that regulates adult neuron number. At approximately the same period, ethanol exposure can cause a dramatic spike in apoptotic cell death. While ethanol-induced apoptosis
Externí odkaz:
https://doaj.org/article/29273d561a184576bf39ff159d37efcc
Autor:
Ju-Hyun Lee, Dun-Sheng Yang, Chris N. Goulbourne, Eunju Im, Philip Stavrides, Anna Pensalfini, Han Chan, Cedric Bouchet-Marquis, Cynthia Bleiwas, Martin J. Berg, Chunfeng Huo, James Peddy, Monika Pawlik, Efrat Levy, Mala Rao, Mathias Staufenbiel, Ralph A. Nixon
Publikováno v:
Nature Neuroscience. 25:688-701
Autophagy is markedly impaired in Alzheimer’s disease (AD). Here we reveal unique autophagy dysregulation within neurons in five AD mouse models in vivo and identify its basis using a neuron-specific transgenic mRFP-eGFP-LC3 probe of autophagy and
Autor:
Cynthia Bleiwas, Cátia M. Teixeira, Robert M. Sears, Stefanie Canals-Baker, John F. Smiley, Mariko Saito, Donald A. Wilson, Sharifa Z. Williams
Publikováno v:
Alcohol
In animal models that mimic human third-trimester fetal development, ethanol causes substantial cellular apoptosis in the brain, but for most brain structures, the extent of permanent neuron loss that persists into adulthood is unknown. We injected e
Autor:
Cátia M. Teixeira, Mark S. Ansorge, John F. Smiley, Robert H. Edwards, Edenia C. Menezes, Nao Chuhma, Relish Shah, Cynthia Bleiwas, Francisco X. Castellanos, Stephen Rayport, Catarina Cunha, Rebecca P. Seal
Publikováno v:
Molecular psychiatry
Serotonin and dopamine are associated with multiple psychiatric disorders. How they interact during development to affect subsequent behavior remains unknown. Knockout of the serotonin transporter or postnatal blockade with selective serotonin reupta
Autor:
Ursula Germann, Cynthia Bleiwas, John Alam, Dun-Sheng Yang, Balapal S. Basavarajappa, Sandeep Malampati, John Harrison, Kelly Blackburn, Afina W. Lemstra, Paul Maruff, Monika Plawik, Shivakumar Subbanna, Amanda Gardner, Niels D. Prins, Charlotte E. Teunissen, Ralph A. Nixon, Ying Jiang, John F. Smiley, Anna Pensalfini, Stephen N. Gomperts, Sandipkumar Darji, Philip Scheltens, James Peddy, Philip Stavrides
The endosome-associated protein Rab5 is a central player in the molecular mechanisms leading to degeneration of basal forebrain cholinergic neurons (BFCN), a long-standing target for drug development. As p38α kinase is a Rab-5 activator, we hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a29c5651356ef59817c7a436ae57df45
https://doi.org/10.21203/rs.3.rs-1061364/v1
https://doi.org/10.21203/rs.3.rs-1061364/v1
Autor:
Judith Betz, Mariko Saito, John F. Smiley, Cynthia Bleiwas, Maria Hui, Eva Petkova, Donald A. Wilson, Kurt Masiello
Publikováno v:
Brain Struct Funct
Neonatal brain lesions cause deficits in structure and function of the cerebral cortex that sometimes are not fully expressed until adolescence. To better understand the onset and persistence of changes caused by postnatal day 7 (P7) ethanol treatmen
Autor:
Martin J. Berg, Daniel C. Javitt, John F. Smiley, Cynthia Bleiwas, Mala V. Rao, Jean-Pierre Julien, Balapal S. Basavarajappa, Henry Sershen, Audrey Hashim, Sandipkumar Darji, Donald A. Wilson, Ralph A. Nixon, Shivakumar Subbanna, Veeranna, Aidong Yuan, David N. Guifoyle, Asok Kumar
Publikováno v:
Translational Psychiatry, Vol 8, Iss 1, Pp 1-12 (2018)
Translational Psychiatry
Translational Psychiatry
Neurofilament (NFL) proteins have recently been found to play unique roles in synapses. NFL is known to interact with the GluN1 subunit of N-methyl-d-aspartic acid (NMDAR) and be reduced in schizophrenia though functional consequences are unknown. He
Autor:
Ralph A. Nixon, Ursula Germann, John Alam, Philip Stavrides, Dun-Sheng Yang, Ying Jiang, John F. Smiley, Cynthia Bleiwas, Sandipkumar Darji
Publikováno v:
Alzheimer's & Dementia. 15
Autor:
Balapal S. Basavarajappa, Philip Stavrides, Chris N. Goulbourne, Monika Pawlik, Ju-Hyun Lee, Anna Pensalfini, Cynthia Bleiwas, Seonil Kim, Sandipkumar Darji, Martin J. Berg, Ying Jiang, John F. Smiley, Ralph A. Nixon, Shivakumar Subbanna, Chunfeng Huo
Publikováno v:
SSRN Electronic Journal.
Neuronal endosomal dysfunction, the earliest known pathobiology specific to Alzheimer’s disease (AD), is mediated by aberrant activation of Rab5 triggered by APP-βeta secretase cleaved C-terminal fragment (APP-βCTF). To distinguish pathophysiolog