Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Cynthia A. Reinhart-King"'
Autor:
Jian Zhang, Jenna A. Mosier, Yusheng Wu, Logan Waddle, Paul V. Taufalele, Wenjun Wang, Heng Sun, Cynthia A. Reinhart‐King
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Collective cell migration is a model for nonequilibrium biological dynamics, which is important for morphogenesis, pattern formation, and cancer metastasis. The current understanding of cellular collective dynamics is based primarily on cell
Externí odkaz:
https://doaj.org/article/b4941d2c5e4b46c781e11715e688076a
Autor:
Wenjun Wang, Matthew R. Zanotelli, Lindsey N. Sabo, Emily D. Fabiano, Natalie M. Goldfield, Chloe Le, Elle P. Techasiriwan, Santiago Lopez, Emily D. Berestesky, Cynthia A. Reinhart-King
Publikováno v:
APL Bioengineering, Vol 8, Iss 2, Pp 026120-026120-9 (2024)
Tumor vasculature plays a crucial role in tumor progression, affecting nutrition and oxygen transportation as well as the efficiency of drug delivery. While targeting pro-angiogenic growth factors has been a significant focus for treating tumor angio
Externí odkaz:
https://doaj.org/article/063ed9fe566747cc816bfb97adfc8a28
Autor:
Korie A. Grayson, Joshua D. Greenlee, Lauren E. Himmel, Lauren A. Hapach, Cynthia A. Reinhart-King, Michael R. King
Publikováno v:
Pathology and Oncology Research, Vol 30 (2024)
Mounting evidence suggests that the immune landscape within prostate tumors influences progression, metastasis, treatment response, and patient outcomes. In this study, we investigated the spatial density of innate immune cell populations within NOD.
Externí odkaz:
https://doaj.org/article/4c61c59810e74e768b62296fe8e62724
Cancer-associated fibroblasts in early-stage lung adenocarcinoma correlate with tumor aggressiveness
Autor:
Georgii Vasiukov, Yong Zou, Maria-Fernanda Senosain, Jamshedur S. M. Rahman, Sanja Antic, Katherine M. Young, Eric L. Grogan, Michael N. Kammer, Fabien Maldonado, Cynthia A. Reinhart-King, Pierre P. Massion
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Lung adenocarcinoma (LUAD) is the predominant type of lung cancer in the U.S. and exhibits a broad variety of behaviors ranging from indolent to aggressive. Identification of the biological determinants of LUAD behavior at early stages can i
Externí odkaz:
https://doaj.org/article/0aa600558c58426ca5beeb5b7def2354
Autor:
Lauren A. Hapach, Wenjun Wang, Samantha C. Schwager, Devika Pokhriyal, Emily D. Fabiano, Cynthia A. Reinhart-King
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Background Intratumor heterogeneity is a well-established hallmark of cancer that impedes cancer research, diagnosis, and treatment. Previously, we phenotypically sorted human breast cancer cells based on migratory potential. When injected i
Externí odkaz:
https://doaj.org/article/74f55ca45e284d36a5bce61053d4ab43
Autor:
Maria Lopez-Cavestany, Su Bin Hahn, Jacob M. Hope, Noah T. Reckhorn, Joshua D. Greenlee, Samantha C. Schwager, Jacob A. VanderBurgh, Cynthia A. Reinhart-King, Michael R. King
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106275- (2023)
Summary: Cells utilize calcium channels as one of the main signaling mechanisms to sense changes in the extracellular space and convert these changes to intracellular signals. Calcium regulates several key signaling networks, such as the induction of
Externí odkaz:
https://doaj.org/article/e150ebe4d8d04bd99f38fa0ec25e62ce
Autor:
Wenjun Wang, Paul V. Taufalele, Martial Millet, Kevin Homsy, Kyra Smart, Emily D. Berestesky, Curtis T. Schunk, Matthew M. Rowe, Francois Bordeleau, Cynthia A. Reinhart-King
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112338- (2023)
Summary: During intravasation, cancer cells cross the endothelial barrier and enter the circulation. Extracellular matrix stiffening has been correlated with tumor metastatic potential; however, little is known about the effects of matrix stiffness o
Externí odkaz:
https://doaj.org/article/7fdc709fb6454d83b7c97e3b8661d0fc
Autor:
Jacob M. Hope, Jenna A. Dombroski, Rebecca S. Pereles, Maria Lopez-Cavestany, Joshua D. Greenlee, Samantha C. Schwager, Cynthia A. Reinhart-King, Michael R. King
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background T cell activation is a mechanical process as much as it is a biochemical process. In this study, we used a cone-and-plate viscometer system to treat Jurkat and primary human T cells with fluid shear stress (FSS) to enhance the act
Externí odkaz:
https://doaj.org/article/393625c95a5b4e23af5124ff46e1efcc
Autor:
Lauren K. Wareham, John Kuchtey, Hang-Jing Wu, Evan Krystofiak, Yusheng Wu, Cynthia A. Reinhart-King, Rachel W. Kuchtey
Publikováno v:
Matrix Biology Plus, Vol 16, Iss , Pp 100120- (2022)
Lysyl oxidase-like 1 encoded by the LOXL1 gene is a member of the lysyl oxidase family of enzymes that are important in the maintenance of extracellular matrix (ECM)-rich tissue. LOXL1 is important for proper elastic fiber formation and mice lacking
Externí odkaz:
https://doaj.org/article/7c4668119b6448e9a94d441e342eee23
Autor:
Samantha C. Schwager, Jenna A. Mosier, Reethi S. Padmanabhan, Addison White, Qinzhe Xing, Lauren A. Hapach, Paul V. Taufalele, Ismael Ortiz, Cynthia A. Reinhart-King
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105190- (2022)
Summary: Intracellular and environmental cues result in heterogeneous cancer cell populations with different metabolic and migratory behaviors. Although glucose metabolism and epithelial-to-mesenchymal transition have previously been linked, we aim t
Externí odkaz:
https://doaj.org/article/b88984cec234459bb1111c2b87caae70