Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Cynthia A. Moylan"'
Autor:
Cynthia A. Moylan, Alisha M. Mavis, Dereje Jima, Rachel Maguire, Mustafa Bashir, Jeongeun Hyun, Melanie N. Cabezas, Alice Parish, Donna Niedzwiecki, Anna Mae Diehl, Susan K. Murphy, Manal F. Abdelmalek, Cathrine Hoyo
Publikováno v:
Epigenetics, Vol 17, Iss 11, Pp 1446-1461 (2022)
Non-Alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children. Epigenetic alterations, such as through DNA methylation (DNAm), may link adverse childhood exposures and fatty liver and provide non-invasive methods
Externí odkaz:
https://doaj.org/article/340dddde15ac419da0f5f9f960cb993c
Autor:
Kara Wegermann, Marat Fudim, Ricardo Henao, Catherine F. Howe, Robert McGarrah, Cynthia Guy, Manal F. Abdelmalek, Anna Mae Diehl, Cynthia A. Moylan
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 14 (2023)
Background Nonalcoholic fatty liver disease (NAFLD) and heart failure with preserved ejection fraction (HFpEF) share common risk factors, including obesity and diabetes. They are also thought to be mechanistically linked. The aim of this study was to
Externí odkaz:
https://doaj.org/article/b039730bdfb84d48a651f270b0cc3361
Autor:
Adriana C. Vidal, Cynthia A. Moylan, Julius Wilder, Delores J. Grant, Susan K. Murphy, Cathrine Hoyo
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Liver cancer incidence has tripled since the early 1980s, making this disease one of the fastest rising types of cancer and the third leading cause of cancer-related deaths worldwide. In the US, incidence varies by geographic location and race, with
Externí odkaz:
https://doaj.org/article/3febe2a8078841bf8af65ef6d144307e
Autor:
Anthony E. Peters, Ambarish Pandey, Colby Ayers, Kara Wegermann, Robert W. McGarrah, Justin L. Grodin, Manal F. Abdelmalek, Tarek Bekfani, Vanessa Blumer, Anna Mae Diehl, Cynthia A. Moylan, Marat Fudim
Publikováno v:
ESC Heart Failure, Vol 8, Iss 2, Pp 842-848 (2021)
Abstract Aims Non‐alcoholic fatty liver disease leads to progressive liver fibrosis and appears to be a frequent co‐morbid disease in heart failure with preserved ejection fraction (HFpEF). It is well known that liver fibrosis severity predicts f
Externí odkaz:
https://doaj.org/article/e67e539858ad4fc2b3ae455e47041b95
Sex and Menopause Modify the Effect of Single Nucleotide Polymorphism Genotypes on Fibrosis in NAFLD
Autor:
Kara Wegermann, Melanie E. Garrett, Jiayin Zheng, Andrea Coviello, Cynthia A. Moylan, Manal F. Abdelmalek, Shein‐Chung Chow, Cynthia D. Guy, Anna Mae Diehl, Allison Ashley‐Koch, Ayako Suzuki
Publikováno v:
Hepatology Communications, Vol 5, Iss 4, Pp 598-607 (2021)
The development of fibrosis in nonalcoholic fatty liver disease (NAFLD) is influenced by genetics, sex, and menopausal status, but whether genetic susceptibility to fibrosis is influenced by sex and reproductive status is unclear. Our aim was to iden
Externí odkaz:
https://doaj.org/article/b7925e634c3749e48299369bbda597e9
Autor:
Kara Wegermann, Catherine Howe, Ricardo Henao, Ying Wang, Cynthia D. Guy, Manal F. Abdelmalek, Anna Mae Diehl, Cynthia A. Moylan
Publikováno v:
Hepatology Communications, Vol 5, Iss 4, Pp 608-617 (2021)
Identifying patients at higher risk for poor outcomes from nonalcoholic fatty liver disease (NAFLD) remains challenging. Metabolomics, the comprehensive measurement of small molecules in biological samples, has the potential to reveal novel noninvasi
Externí odkaz:
https://doaj.org/article/8827ebe784e343ad945032872f158e20
Autor:
Marat Fudim, Lin Zhong, Kershaw V. Patel, Rohan Khera, Manal F. Abdelmalek, Anna Mae Diehl, Robert W. McGarrah, Jeroen Molinger, Cynthia A. Moylan, Vishal N. Rao, Kara Wegermann, Ian J. Neeland, Ethan A. Halm, Sandeep R. Das, Ambarish Pandey
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021)
Background Nonalcoholic fatty liver disease (NAFLD) and heart failure (HF) are increasing in prevalence. The independent association between NAFLD and downstream risk of HF and HF subtypes (HF with preserved ejection fraction and HF with reduced ejec
Externí odkaz:
https://doaj.org/article/0348b254322045d6b98f37ff6e5d05af
Autor:
Kuo Du, Satish K. Chitneni, Ayako Suzuki, Ying Wang, Ricardo Henao, Jeongeun Hyun, Richard T. Premont, Susanna Naggie, Cynthia A. Moylan, Mustafa R. Bashir, Manal F. Abdelmalek, Anna Mae Diehl
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 1-21 (2020)
Background & Aims: Nonalcoholic steatohepatitis (NASH) occurs in the context of aberrant metabolism. Glutaminolysis is required for metabolic reprograming of hepatic stellate cells (HSCs) and liver fibrogenesis in mice. However, it is unclear how cha
Externí odkaz:
https://doaj.org/article/2913df394d7c4f06abb93625a9bfe0c6
Autor:
Oliver Glass, Ricardo Henao, Keyur Patel, Cynthia D. Guy, Hans J. Gruss, Wing‐Kin Syn, Cynthia A. Moylan, Robert Streilein, Russell Hall, Anna Mae Diehl, Manal F. Abdelmalek
Publikováno v:
Hepatology Communications, Vol 2, Iss 11, Pp 1344-1355 (2018)
The severity of hepatic fibrosis is the primary predictor of liver‐related morbidity and mortality in patients with nonalcoholic fatty liver disease (NAFLD). Unfortunately, noninvasive serum biomarkers for NAFLD‐associated fibrosis are limited. W
Externí odkaz:
https://doaj.org/article/15c5b601b1564633b905485bbd685159
Autor:
Sarah E. Kleinstein, Matthew Rein, Manal F. Abdelmalek, Cynthia D. Guy, David B. Goldstein, Anna Mae Diehl, Cynthia A. Moylan
Publikováno v:
Hepatology Communications, Vol 2, Iss 9, Pp 1021-1029 (2018)
Abstract Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous disease with highly variable outcomes. Patients with simple steatosis typically experience a benign course, whereas those with more advanced liver injury, nonalcoholic steatohepatit
Externí odkaz:
https://doaj.org/article/2a83b6bb981c4ad98bdc25157f8217b4