Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Cynthia A. Luppen"'
Autor:
Calvin J. Kuo, Kevin Wei, Anthony DeBoer, Irving L. Weissman, Jill A. Helms, Jae-Beom Kim, Charles Chan, Ching-Cheng Chen, Cynthia A. Luppen, Daniel Kraft
Publikováno v:
Nature
Little is known about the formation of niches, local micro-environments required for stem-cell maintenance. Here we develop an in vivo assay for adult haematopoietic stem-cell (HSC) niche formation. With this assay, we identified a population of prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a3aed4061c44391494dac40e90e6b0
https://doi.org/10.1038/nature07547
https://doi.org/10.1038/nature07547
Publikováno v:
Growth Factors. 26:226-237
Pharmacological glucocorticoids (GCs) inhibit bone formation, leading to osteoporosis. GCs inhibit bone morphogenetic protein-2 (Bmp2) expression, and rhBMP-2 restores mineralization in GC-arrested osteoblast cultures. To better understand how GCs re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad02450c3945fcf4a061619f700a17e4
https://doi.org/10.1080/08977190802277880
https://doi.org/10.1080/08977190802277880
Autor:
Jill A. Helms, Caroline H. Damsky, Yu Jin Park, Philipp Leucht, Cynthia A. Luppen, Jae-Beom Kim, Hilary E. Beggs
Publikováno v:
Bone. 41:39-51
Integrins link the inside of a cell with its outside environment and in doing so regulate a wide variety of cell behaviors. Integrins are well known for their roles in angiogenesis and cell migration but their functions in bone formation are less cle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725c4b140f2eed1ffd3d2264e5dec899
https://doi.org/10.1016/j.bone.2007.01.024
https://doi.org/10.1016/j.bone.2007.01.024
Autor:
Baruch Frenkel, Nathalie Leclerc, Tommy Noh, Adele L. Boskey, Artem Barski, Cynthia A. Luppen, Elisheva Smith, Arvinder Khokhar
Publikováno v:
Journal of Biological Chemistry. 278:44995-45003
Glucocorticoids (GCs) inhibit bone formation in vivo. In MC3T3-E1 osteoblasts, chronic administration of 1 μm dexamethasone (DEX) starting at confluency results in >98% inhibition of bone morphogenetic protein 2 (BMP-2) expression and apatite minera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e278e994b31512cedd1112b0304cfcc
https://doi.org/10.1074/jbc.m306730200
https://doi.org/10.1074/jbc.m306730200
Publikováno v:
Journal of Bone and Mineral Research. 18:1186-1197
The anti-glucocorticoid potential of BMP-2 in osteoblasts was tested in MC3T3-E1 cells using dexamethasone (1 μM) and rhBMP-2 (10 or 100 ng/ml). rhBMP-2 restored mineralization but not condensation or collagen accumulation. These results demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac804b912cd9eda501b2d8f8747c516
https://doi.org/10.1359/jbmr.2003.18.7.1186
https://doi.org/10.1359/jbmr.2003.18.7.1186
Autor:
Alexander A. Theologis, Subhash Kulkarni, Lillian F. Zhang, Joseph C. Wu, Sujin Park, Jae Beom Kim, Kyle M. Loh, Yongquan Gong, Michael T. Longaker, Paul Lindau, Graham G. Walmsley, Derrick C. Wan, Wen Jiang, Jun Seita, Anthony DeBoer, Irving L. Weissman, Charles Chan, Justin Vincent-Tompkins, Andrew S. Lee, James Y. Chen, Ching-Cheng Chen, Eun Young Seo, Debashis Sahoo, Cynthia A. Luppen, Daniel Kraft, Divya Nag
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 110, iss 31
Organs are composites of tissue types with diverse developmental origins, and they rely on distinct stem and progenitor cells to meet physiological demands for cellular production and homeostasis. How diverse stem cell activity is coordinated within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b67a639148502b8267dcb15917c1d3
https://pubmed.ncbi.nlm.nih.gov/23858471
https://pubmed.ncbi.nlm.nih.gov/23858471
Autor:
Roel Nusse, Jae-Beom Kim, Philipp Leucht, Kentson Lam, Cynthia A. Luppen, Derk ten Berge, Jill A. Helms
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 22(12)
Tissue regeneration is increasingly viewed as reactivation of a developmental process that, when misappropriated, can lead to malignant growth. Therefore, understanding the molecular and cellular pathways that govern tissue regeneration provides a gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b66274d3aa6a1a6f7f838eb7b307e7
https://pubmed.ncbi.nlm.nih.gov/17696762
https://pubmed.ncbi.nlm.nih.gov/17696762
Autor:
Baruch Frenkel, Shailender Nagpal, Cynthia A. Luppen, Joseph G. Hacia, Nathalie Leclerc, Vincent V. Ho, Elisheva Smith
Publikováno v:
Journal of molecular endocrinology. 33(1)
Glucocorticoid (GC) treatment for the management of autoimmune and inflammatory diseases is associated with decreased bone formation and increased risk for fracture. In MC3T3-E1 cell cultures, 0.1-1 microM dexamethasone (DEX) arrests development of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5257cd8341b9227e87a6528cb7c58e3c
https://pubmed.ncbi.nlm.nih.gov/15291752
https://pubmed.ncbi.nlm.nih.gov/15291752
Autor:
Jae-Beom Kim, Anthony DeBoer, Irving L. Weissman, Cynthia A. Luppen, Daniel Kraft, Kevin Wei Wei, Ching-Cheng Chen, Charles Chan
Publikováno v:
Blood. 112:3574-3574
Introduction: Identification and understanding of the cells and processes that can generate, sustain and influence the HSC niche and hematopoiesis are critical for the development of a more comprehensive knowledge of normal hematopoiesis, stem cell h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2c517f6846d28c5b6e4351a3c2a506c
https://doi.org/10.1182/blood.v112.11.3574.3574
https://doi.org/10.1182/blood.v112.11.3574.3574
Publikováno v:
Biology of Blood and Marrow Transplantation. (2):28-29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9e109fded21230b0c977708d4822c3