Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Cynthia A. Burns"'
Autor:
Matthew A Gorris MD, McKenzie L Needham BS, Kayla C Finnegan BS, Corey S Obermiller MS, Lauren Witek MStat, Reese W Randle MD, Cynthia A Burns MD
Publikováno v:
Journal of Patient Experience, Vol 11 (2024)
Research surrounding tumor boards has focused on patient outcomes and care coordination. Little is known about the patient experience with tumor boards. This survey examined aspects of the patient experience for patients presented at our multidiscipl
Externí odkaz:
https://doaj.org/article/6552f00aba7e4e1a82a757aeeca6c55c
Publikováno v:
Medical Science Educator. 32:773-777
With increasingly complicated patients and faster throughput, time for thorough critical thinking and thoughtful clinical documentation is limited, especially in the training environment. Advocating for the value of clinical documentation as a robust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa18eb467b69bf40dae93d93e5bbf1f
https://doi.org/10.1007/s40670-022-01570-5
https://doi.org/10.1007/s40670-022-01570-5
Publikováno v:
Journal of diabetes science and technology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66267cbf85b5aec61f6aeeb8b94b53b
https://pubmed.ncbi.nlm.nih.gov/36350175
https://pubmed.ncbi.nlm.nih.gov/36350175
Autor:
Stefan Senger, Máire A. Convery, Robert J. Young, Stephanie Irvine, Iain M. McLay, Robert I. West, David J. Belton, Savvas Kleanthous, Carl Adams, John R. Toomey, Anne M. Exall, Anthony J. Pateman, Theresa J. Roethke, Caroline M. Whittaker, Laiq Chaudry, David E. Davies, Angela Patikis, Cynthia L. Burns-Kurtis, Nigel S. Watson, Gary J. Stelman, David W. Brown, John D. Harling, Wendy R. Irving, Chuen Chan, Ping Zhou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1588-1592
The discovery and evaluation of potent and long-acting oral sulfonamidopyrrolidin-2-one factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs are described. Unexpected selectivity issues versus tissue plasminogen activator in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff85f937ce4e89e1a2bcffaac9ddca4
https://doi.org/10.1016/j.bmcl.2011.01.129
https://doi.org/10.1016/j.bmcl.2011.01.129
Autor:
Shobha Senadhi, Joseph P. Marino, Cynthia L. Burns-Kurtis, Lorena A. Kallal, Dwight M. Morrow, Reema K. Thalji, Nambi Aiyar, Joseph A. Erhardt, Elizabeth A. Davenport
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4104-4107
Benzofuran-substituted urea analogs have been identified as novel P2Y1 receptor antagonists. Structure–activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad217af675a169d8f08ec1f0b7898c78
https://doi.org/10.1016/j.bmcl.2010.05.072
https://doi.org/10.1016/j.bmcl.2010.05.072
Autor:
Savvas Kleanthous, Alan D. Borthwick, David Brown, Cynthia L. Burns-Kurtis, Matthew Campbell, Laiq Chaudry, Chuen Chan, Marie-Olive Clarte, Máire A. Convery, John D. Harling, Eric Hortense, Wendy R. Irving, Stephanie Irvine, Anthony J. Pateman, Angela N. Patikis, Ivan L. Pinto, Derek R. Pollard, Theresa J. Roethka, Stefan Senger, Gita P. Shah, Gary J. Stelman, John R. Toomey, Nigel S. Watson, Robert I. West, Caroline Whittaker, Ping Zhou, Robert J. Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:618-622
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa inhibitors, incorporating neutral and basic monoaryl P4 groups, ultimately producing potent inhibitors with effective levels of ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c703cdb093d395dc4c312cc73a2b70
https://doi.org/10.1016/j.bmcl.2009.11.077
https://doi.org/10.1016/j.bmcl.2009.11.077
Autor:
Elizabeth A. Davenport, Reema K. Thalji, Nambi Aiyar, Todd L. Graybill, Peng Li, Allyn T. Londregan, Dwight M. Morrow, Angel I. Morales-Ramos, Terry Kiesow, Steve Zhao, John S. Mecom, Shobha Senadhi, Gregory D. Brown, Lorena A. Kallal, Beth Anne Knapp-Reed, Joseph P. Marino, Cynthia L. Burns-Kurtis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:6222-6226
High-throughput screening of the GSK compound collection against the P2Y(1) receptor identified a novel series of tetrahydro-4-quinolinamine antagonists. Optimal substitution around the piperidine group was pivotal for ensuring activity. An exemplar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e831721dc404f65dc487ba8659b333e
https://doi.org/10.1016/j.bmcl.2008.09.102
https://doi.org/10.1016/j.bmcl.2008.09.102
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:231-239
Epoxy- and dihydroxy-eicosatrienoic acids (EETs and DHETs) are vasoactive cytochrome P450 metabolites of arachidonic acid. Interestingly, however, the mechanism(s) by which EETs/DHETs mediate smooth muscle relaxation remains unclear. In contrast to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a613ffe06355ad3580511c2bd8cff5
https://doi.org/10.1124/jpet.108.145102
https://doi.org/10.1124/jpet.108.145102
Autor:
Anthony J. Pateman, John R. Toomey, Paul F. Koster, Augustin Amour, Saul Needle, Laiq Chaudry, Melanie A Abboud, Champa Patel, Angela Patikis, Cynthia L. Burns-Kurtis, Robert J. Young, Richard E. Valocik, David Brown, Ping Zhou, Chuen Chan, Nigel S. Watson
Publikováno v:
Journal of Cardiovascular Pharmacology. 52:66-71
Background: Factor Xa (FXa) has been a target of considerable interest for drug development efforts aimed at suppressing thrombosis. In this report, a new orally active, small molecule, active-site directed FXa inhibitor, GW813893, has been profiled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4ecf88e87e341213f5fef72bbcb248
https://doi.org/10.1097/fjc.0b013e31817e9b9e
https://doi.org/10.1097/fjc.0b013e31817e9b9e
Autor:
Alan D. Borthwick, Marie Charbaut, Robert J. Young, Máire A. Convery, Ivan Leo Pinto, Andrew M. Mason, Weston Helen Elisabeth, Matthew Campbell, David W. Brown, Anthony J. Pateman, Henry Anderson Kelly, Derek Pollard, Shah Gita Punjabhai, John R. Toomey, N. Paul King, Stefan Senger, Eric Hortense, Ping Zhou, Hawa Diallo, Nigel S. Watson, Wendy R. Irving, Angela Patikis, Cynthia L. Burns-Kurtis, Savvas Kleanthous, Chuen Chan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:28-33
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating basic biaryl P4 groups, producing highly potent inhibitors with significant anticoagulant activitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03145f782eb525e093f927857c7919cd
https://doi.org/10.1016/j.bmcl.2007.11.019
https://doi.org/10.1016/j.bmcl.2007.11.019