Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Cynthia A. Bradham"'
Autor:
Dakota Y Hawkins, Daniel T Zuch, James Huth, Nahomie Rodriguez-Sastre, Kelley R McCutcheon, Abigail Glick, Alexandra T Lion, Christopher F Thomas, Abigail E Descoteaux, William Evan Johnson, Cynthia A Bradham
Publikováno v:
Bioinformatics. 39
Motivation The detection of distinct cellular identities is central to the analysis of single-cell RNA sequencing (scRNA-seq) experiments. However, in perturbation experiments, current methods typically fail to correctly match cell states between con
The larval skeleton of the sea urchinLytechinus variegatusis an ideal model system for studying skeletal patterning; however, our understanding of the etiology of skeletal patterning in sea urchin larvae is limited due to the lack of approaches to li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda90962f9ba1f002d713eadd6a68db4
https://doi.org/10.1101/2022.12.12.520085
https://doi.org/10.1101/2022.12.12.520085
Autor:
Christopher F. Thomas, Dakota Y. Hawkins, Viktoriya Skidanova, Simone R. Marrujo, Janay Gibson, Ziqing Ye, Cynthia A. Bradham
Defining pattern formation mechanisms during embryonic development is important for understanding the etiology of birth defects and to inform tissue engineering approaches. In this study, we used tricaine, a voltage-gated sodium channel (VGSC) inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d47a291b343eaf1a41233e58e02a502
https://doi.org/10.1101/2022.11.18.517086
https://doi.org/10.1101/2022.11.18.517086
Autor:
Nahomie Rodríguez-Sastre, Nicholas Shapiro, Dakota Y. Hawkins, Alexandra T. Lion, Monique Peyreau, Andrea E. Correa, Kristin Dionne, Cynthia A. Bradham
Publikováno v:
Developmental biology. 493
Ethanol is a known vertebrate teratogen that causes craniofacial defects as a component of fetal alcohol syndrome (FAS). Our results show that sea urchin embryos treated with ethanol similarly show broad skeletal patterning defects, potentially analo
Autor:
Dakota Y. Hawkins, Daniel T. Zuch, James Huth, Nahomie Rodriguez-Sastre, Kelley R. McCutcheon, Abigail Glick, Alexandra T. Lion, Christopher F. Thomas, Abigail E. Descoteaux, W. Evan Johnson, Cynthia A. Bradham
MotivationThe detection of distinct cellular identities is central to the analysis of single-cell RNA sequencing experiments. However, in perturbation experiments, current methods typically fail to correctly match cell states between conditions or er
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66344946f455227c24dd089209e4e43b
https://doi.org/10.1101/2022.05.26.493603
https://doi.org/10.1101/2022.05.26.493603
Autor:
Shweta Paresh Kitchloo, Luz Dojer, Cynthia A. Bradham, Daphne Schatzberg, Christopher F. Thomas, Sarah E. Hadyniak, Patrick Reidy, Viktoriya Skidanova, Daniel T. Zuch, Matthew L. Lawton
The mechanism for embryonic dorsal-ventral (DV) symmetry breaking is idiosyncratic to the species, then converges on polarized expression of BMP signaling ligands. Here, we show that V-ATPase (VHA) activity is an early requirement for DV symmetry bre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2484eb1d3717a71746b56645b6a739c
https://doi.org/10.1101/2021.10.18.464707
https://doi.org/10.1101/2021.10.18.464707
Autor:
Adrian Reich, Brian T. Livingston, Akihito Omori, Tomoko F. Shibata, Toko Tsurugaya, Meng Hao, Yui Uchida, Kota Ogawa, Yang Dong, Jason C. K. Leong, Wenting Wan, Sheri Satterfield, Xueyan Li, Masahiro Uesaka, Yongxin Li, Tao Zeng, Hidetoshi Saiga, Tetsuro Ikuta, Cynthia A. Bradham, Wen Wang, Fayou Wang, Gary M. Wessel, Mariko Kondo, Yaondong Ren, R. Andrew Cameron, Rachel L. Flores, Christine Nguyen, Mani Kikuchi, Kazuho Ikeo, Naoki Irie, Tatsuya Ota, Luonan Chen, Shuji Shigenobu, Takahiro Bino, Si Zhang
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Echinoderms are an exceptional group of bilaterians that develop pentameral adult symmetry from a bilaterally symmetric larva. However, the genetic basis in evolution and development of this unique transformation remains to be clarified. Here we repo
Publikováno v:
Methods in cell biology. 151
Autor:
Daniel T, Zuch, Cynthia A, Bradham
Publikováno v:
Methods in cell biology. 151
During sea urchin embryogenesis, primary mesenchyme cells (PMCs) follow a stereotypical migratory program, arrange into a primary pattern, then begin to secrete a bilaterally symmetric calcium carbonate skeleton. Recently identified genes are express
Autor:
Daniel T. Zuch, John D. Hogan, Jonas Ibn-Salem, Miguel A. Andrade-Navarro, Bernd Timmermann, Lingqi Luo, Cynthia A. Bradham, Daphne Schatzberg, Jessica L. Keenan, Naoki Irie, Albert J. Poustka, José Horacio Grau, Dakota Y. Hawkins, Amanda B. Core, Carolyn Blumberg, Emily Speranza, Arjun Lamba, Michael L. Piacentino
Publikováno v:
bioRxiv
Developmental Biology
Developmental Biology
Embryonic development is arguably the most complex process an organism undergoes during its lifetime, and understanding this complexity is best approached with a systems-level perspective. The sea urchin has become a highly valuable model organism fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee7b9ba73ded6efba4e3292e8c47f49