Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Cynthia A, Derdeyn"'
Autor:
Venkata S. Bollimpelli, Pradeep B. J Reddy, Sailaja Gangadhara, Tysheena P. Charles, Samantha L. Burton, Gregory K. Tharp, Tiffany M. Styles, Celia C. Labranche, Justin C. Smith, Amit A. Upadhyay, Anusmita Sahoo, Traci Legere, Ayalnesh Shiferaw, Vijayakumar Velu, Tianwei Yu, Mark Tomai, John Vasilakos, Sudhir P. Kasturi, George M. Shaw, David Montefiori, Steven E. Bosinger, Pamela A. Kozlowski, Bali Pulendran, Cynthia A. Derdeyn, Eric Hunter, Rama R. Amara
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Route of immunization can markedly influence the quality of immune response. Here, we show that intradermal (ID) but not intramuscular (IM) modified vaccinia Ankara (MVA) vaccinations provide protection from acquisition of intravaginal tier2
Externí odkaz:
https://doaj.org/article/101d7faa095245b791894f88734b70d5
Autor:
Rohini Mopuri, Sarah Welbourn, Tysheena Charles, Pooja Ralli-Jain, David Rosales, Samantha Burton, Areeb Aftab, Kirti Karunakaran, Kathryn Pellegrini, William Kilembe, Etienne Karita, Sandrasegaram Gnanakaran, Amit A Upadhyay, Steven E Bosinger, Cynthia A Derdeyn
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011717 (2023)
A protective HIV-1 vaccine has been hampered by a limited understanding of how B cells acquire neutralizing activity. Our previous vaccines expressing two different HIV-1 envelopes elicited robust antigen specific serum IgG titers in 20 rhesus macaqu
Externí odkaz:
https://doaj.org/article/1134d83f0e044f18b5105af8a940f58d
Autor:
Kiran S. Toti, Nicole Pribut, Michael D’Erasmo, Madhuri Dasari, Savita K. Sharma, Perry W. Bartsch, Samantha L. Burton, Hannah B. Gold, Anatoliy Bushnev, Cynthia A. Derdeyn, Adriaan E. Basson, Dennis C. Liotta, Eric J. Miller
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Nucleoside- and nucleotide-based therapeutics are indispensable treatment options for patients suffering from malignant and viral diseases. These agents are most commonly administered to patients as prodrugs to maximize bioavailability and efficacy.
Externí odkaz:
https://doaj.org/article/95897a2077a94f00b1666c0194367d18
Autor:
Tiffany M. Styles, Sailaja Gangadhara, Pradeep B. J. Reddy, Anusmita Sahoo, Ayalensh Shiferaw, Sarah Welbourn, Pamela A. Kozlowski, Cynthia A. Derdeyn, Vijayakumar Velu, Rama Rao Amara
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Stabilized HIV envelope (Env) trimeric protein immunogens have been shown to induce strong autologous neutralizing antibody response. However, there is limited data on the immunogenicity and efficacy of stabilized Env expressed by a viral vector-base
Externí odkaz:
https://doaj.org/article/81f9a87b6bff43e3a8a1399b0ad63c82
Autor:
Sarah Welbourn, Srirupa Chakraborty, Jie E Yang, Anne S Gleinich, Sailaja Gangadhara, Salar Khan, Courtney Ferrebee, Bhrugu Yagnik, Samantha Burton, Tysheena Charles, S Abigail Smith, Danielle Williams, Rohini Mopuri, Amit A Upadhyay, Justin Thompson, Matt A Price, Shiyu Wang, Zhaohui Qin, Xiaoying Shen, LaTonya D Williams, Nathan Eisel, Tiffany Peters, Lu Zhang, William Kilembe, Etienne Karita, Georgia D Tomaras, Steven E Bosinger, Rama R Amara, Parastoo Azadi, Elizabeth R Wright, Sandrasegaram Gnanakaran, Cynthia A Derdeyn
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010488 (2022)
Transmitted/founder (T/F) HIV-1 envelope proteins (Envs) from infected individuals that developed neutralization breadth are likely to possess inherent features desirable for vaccine immunogen design. To explore this premise, we conducted an immuniza
Externí odkaz:
https://doaj.org/article/57b66c8bac8a49fbb543e6148e785893
Autor:
Maria Pino, Susan Pereira Ribeiro, Amélie Pagliuzza, Khader Ghneim, Anum Khan, Emily Ryan, Justin L Harper, Colin T King, Sarah Welbourn, Luca Micci, Sol Aldrete, Keith A Delman, Theron Stuart, Michael Lowe, Jason M Brenchley, Cynthia A Derdeyn, Kirk Easley, Rafick P Sekaly, Nicolas Chomont, Mirko Paiardini, Vincent C Marconi
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009825 (2021)
Clinical outcomes are inferior for individuals with HIV having suboptimal CD4 T-cell recovery during antiretroviral therapy (ART). We investigated if the levels of infection and the response to homeostatic cytokines of CD4 T-cell subsets contributed
Externí odkaz:
https://doaj.org/article/067e37f438b34fd7827433be61b176ba
Autor:
Tysheena P Charles, Samantha L Burton, Prabhu S Arunachalam, Christopher A Cottrell, Leigh M Sewall, Venkata S Bollimpelli, Sailaja Gangadhara, Antu K Dey, Andrew B Ward, George M Shaw, Eric Hunter, Rama R Amara, Bali Pulendran, Marit J van Gils, Cynthia A Derdeyn
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009257 (2021)
Stabilized HIV-1 envelope (Env) trimers elicit tier 2 autologous neutralizing antibody (nAb) responses in immunized animals. We previously demonstrated that BG505 SOSIP.664.T332N gp140 (BG505 SOSIP) immunization of rhesus macaques (RM) provided robus
Externí odkaz:
https://doaj.org/article/9eebb505e6de4f35a7e3bc5ad081b207
Autor:
S. Abigail Smith, Samantha L. Burton, William Kilembe, Shabir Lakhi, Etienne Karita, Matt Price, Susan Allen, Cynthia A. Derdeyn
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Multiple antibody effector functions arise in HIV-1 infection that could be harnessed to protect against infection or clear the persistent reservoir. Here, we have investigated the genetic and functional memory B cell and antibody landscape present d
Externí odkaz:
https://doaj.org/article/9e10097fb2454b5eae04d169db6dafa0
Autor:
Anatoliy S. Bushnev, Perry W. Bartsch, Savita Sharma, Kyle E. Giesler, Dennis C. Liotta, Eric J. Miller, Madhuri Dasari, D'erasmo Michael, Adriaan E. Basson, Soyon S. Hwang, Akshay Raghuram, Nicole Pribut, Iskandar Sabrina, Samantha L. Burton, Cynthia A. Derdeyn
Publikováno v:
Journal of Medicinal Chemistry. 64:12917-12937
Tenofovir (TFV) is the cornerstone nucleotide reverse transcriptase inhibitor (NtRTI) in many combination antiretroviral therapies prescribed to patients living with HIV/AIDS. Due to poor cell permeability and oral bioavailability, TFV is administere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fe8f64ae776888f4188d89e13f619a
https://doi.org/10.1021/acs.jmedchem.1c01083
https://doi.org/10.1021/acs.jmedchem.1c01083
Autor:
Anusmita Sahoo, Andrew T. Jones, Narayanaiah Cheedarla, Sailaja Gangadhara, Vicky Roy, Tiffany M. Styles, Ayalnesh Shiferaw, Korey L. Walter, LaTonya D. Williams, Xiaoying Shen, Gabriel Ozorowski, Wen-Hsin Lee, Samantha Burton, Lasanajak Yi, Xuezheng Song, Zhaohui S. Qin, Cynthia A. Derdeyn, Andrew B. Ward, John D. Clements, Raghavan Varadarajan, Georgia D. Tomaras, Pamela A. Kozlowski, Galit Alter, Rama Rao Amara
Publikováno v:
Sci Immunol
The rising global HIV-1 burden urgently requires vaccines capable of providing heterologous protection. Here, we developed a clade C HIV-1 vaccine consisting of priming with modified vaccinia Ankara (MVA) and boosting with cyclically permuted trimeri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8125d827905442a94d59c92d40eda042
https://doi.org/10.1126/sciimmunol.abl4102
https://doi.org/10.1126/sciimmunol.abl4102