Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Cynthia Barrett"'
Autor:
Miriam TH Harris, Jordana Laks, Emily Elizabeth Hurstak, Jennifer P. Jain, Audrey M. Lambert, Ariel D. Maschke, Sarah M. Bagley, John Farley, Phillip O. Coffin, Vanessa M. McMahan, Cynthia Barrett, Alexander Y. Walley, Christine M. Gunn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68da4e32440556e6334186c29532a376
https://doi.org/10.2139/ssrn.4329924
https://doi.org/10.2139/ssrn.4329924
Autor:
Cynthia Barrett
The origins of a remarkable number of everyday words and phrases are anchored in our seafaring past. Three Sheets to the Wind: The Nautical Origins of Everyday Expressions is an entertaining compilation revealing the maritime roots of common English
Autor:
Cynthia Barrett, Alexandra E. Gould, Janice Chin, Mable Brunson, John Ringeling, Christopher Tsu, R. Scott Rowland, Krista Wager, Kara Hoar, Juan Gutierrez, He Xu, Dylan England, Kris Garcia, Christopher Blackburn, Kenneth Gigstad
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5450-5454
Acyl derivatives of 4-(aminomethyl)-N-hydroxybenzamide are potent sub-type selective HDAC6 inhibitors. Constrained heterocyclic analogs based on 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine show further enhanced HDAC6 selectivity and inhibitory activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76984e37b68c0abc013438b7f50f96ec
https://doi.org/10.1016/j.bmcl.2014.10.022
https://doi.org/10.1016/j.bmcl.2014.10.022
Autor:
Edward J. Olhava, Paul Hales, Cynthia Barrett, Jane X. Liu, Matthew Jones, Frank J. Bruzzese, Kenneth M. Gigstad, Khristofer Garcia, Christopher Tsu, Darshan S. Sappal, Teresa A. Soucy, Paul E. Fleming, Christopher Blackburn, Michael D. Sintchak, Jonathan L. Blank, Nancy Bump, Lawrence R. Dick
Publikováno v:
Biochemical Journal
The mammalian 26S proteasome is a 2500 kDa multi-catalytic complex involved in intracellular protein degradation. We describe the synthesis and properties of a novel series of non-covalent di-peptide inhibitors of the proteasome based [corrected] on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f48642b351f04b2dc37016661e3f601
https://doi.org/10.1042/bj20100383
https://doi.org/10.1042/bj20100383
Autor:
Michael E. Bembenek, Ping Li, Jennifer Alley, Heidi Spurling, Thomas F. Parsons, William D. Mallender, Jacqueline C. Pulido, Cynthia Barrett
Publikováno v:
ASSAY and Drug Development Technologies. 4:661-669
Adenine phosphoribosyltransferase plays a role in purine salvage by catalyzing the direct conversion of adenine to adenosine monophosphate. The involvement of the purine salvage pathway in tumor proliferation and angiogenesis makes adenine phosphorib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fc5aac54ccf01e95f0be0741ef04c1
https://doi.org/10.1089/adt.2006.4.661
https://doi.org/10.1089/adt.2006.4.661
Publikováno v:
Bioorganic Chemistry. 30:264-275
Potent and selective cathepsin B inhibitors have previously been synthesized based upon the natural product cysteine protease inhibitor E-64. X-ray crystal data indicates that these compounds interact through their free carboxylate with the positivel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb983099351175f004577c483a373d6e
https://doi.org/10.1016/s0045-2068(02)00009-3
https://doi.org/10.1016/s0045-2068(02)00009-3
Autor:
R. Scott Rowland, Juan A Gutierrez, Alexandra E. Gould, John Ringeling, Chris Tsu, Christopher Blackburn, Chrissie Lynch, Kenneth M. Gigstad, Sean Harrison, Janice Chin, He Xu, Kris Garcia, Kara Hoar, Cynthia Barrett
Publikováno v:
Journal of medicinal chemistry. 56(18)
A screen for HDAC6 inhibitors identified acyl derivatives of 4-(aminomethyl)-N-hydroxybenzamide as potent leads with unexpected selectivity over the other subtypes. We designed and synthesized constrained heterocyclic analogues such as tetrahydroisoq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c72519ef83857755b72ecee1d7a3a74
https://pubmed.ncbi.nlm.nih.gov/23964961
https://pubmed.ncbi.nlm.nih.gov/23964961
Autor:
Matthew O. Duffey, Tricia J. Vos, Ruth Adams, Jennifer Alley, Justin Anthony, Cynthia Barrett, Indu Bharathan, Douglas Bowman, Nancy J. Bump, Ryan Chau, Courtney Cullis, Denise L. Driscoll, Amy Elder, Nancy Forsyth, Jonathan Frazer, Jianping Guo, Luyi Guo, Marc L. Hyer, David Janowick, Bheemashankar Kulkarni, Su-Jen Lai, Kerri Lasky, Gang Li, Jing Li, Debra Liao, Jeremy Little, Bo Peng, Mark G. Qian, Dominic J. Reynolds, Mansoureh Rezaei, Margaret Porter Scott, Todd B. Sells, Vaishali Shinde, Qiuju Judy Shi, Michael D. Sintchak, Francois Soucy, Kevin T. Sprott, Stephen G. Stroud, Michelle Nestor, Irache Visiers, Gabriel Weatherhead, Yingchun Ye, Natalie D’Amore
Publikováno v:
Journal of medicinal chemistry. 55(1)
This article describes the discovery of a series of potent inhibitors of Polo-like kinase 1 (PLK1). Optimization of this benzolactam-derived chemical series produced an orally bioavailable inhibitor of PLK1 (12c, MLN0905). In vivo pharmacokinetic-pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71360d15b44c1a6fcfa39401ef5e4fbf
https://pubmed.ncbi.nlm.nih.gov/22070629
https://pubmed.ncbi.nlm.nih.gov/22070629
Autor:
Kenneth M. Gigstad, Khristofer Garcia, Paul Hales, Nancy Bump, Frank J. Bruzzese, Paul E. Fleming, Lawrence R. Dick, Zhigen Hu, Christopher Blackburn, Matthew Jones, Christopher Tsu, Michael D. Sintchak, Cynthia Barrett, Jane X. Liu, Jonathan L. Blank, Darshan S. Sappal
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(22)
Starting from a tripeptide screening hit, a series of dipeptide inhibitors of the proteasome with Thr as the P3 residue has been optimized with the aid of crystal structures in complex with the β-5/6 active site of y20S. Derivative 25, (β5 IC(50)=7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed960939ca4ea0080006c362ffe95f3
https://pubmed.ncbi.nlm.nih.gov/20875739
https://pubmed.ncbi.nlm.nih.gov/20875739
Autor:
Nancy Bump, Cindy Q. Xia, Lawrence R. Dick, Paul Hales, Frank J. Bruzzese, Cynthia Barrett, Darshan S. Sappal, Kenneth M. Gigstad, Khristofer Garcia, Jane X. Liu, Christopher Blackburn, Jonathan L. Blank, Paul E. Fleming, Masayuki Nagayoshi, Michael D. Sintchak, Christopher Tsu, Matthew Jones, Xiansi Zhou
Publikováno v:
MedChemComm. 3:710
Inhibition of the proteasome by covalent inhibitors is a clinically proven anti-cancer therapy. We report here that dipeptides with a P3 neopentyl Asn residue are potent, reversible, non-covalent inhibitors selective for the chymotryptic activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f31a337948e93755309d48a1aa562b07
https://doi.org/10.1039/c2md20060k
https://doi.org/10.1039/c2md20060k