Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Cynthia, Wolberger"'
Publikováno v:
eLife, Vol 9 (2020)
Methylation of histone H3K4 is a hallmark of actively transcribed genes that depends on mono-ubiquitination of histone H2B (H2B-Ub). H3K4 methylation in yeast is catalyzed by Set1, the methyltransferase subunit of COMPASS. We report here the cryo-EM
Externí odkaz:
https://doaj.org/article/005a5064c3494de28398120b557402b3
Autor:
Muhammad Jbara, Shay Laps, Michael Morgan, Guy Kamnesky, Guy Mann, Cynthia Wolberger, Ashraf Brik
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Cysteine side chains are reactive sites of protein synthesis and modification. Here, the authors show that tuning palladium chemoselectivity allows for selective removal of several cysteine protection groups, and use their method to synthesize challe
Externí odkaz:
https://doaj.org/article/56cd1cea37cd4f67b98746267de30aab
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2310-2319 (2017)
Sirtuin enzymes depend on NAD+ to catalyze protein deacetylation. Therefore, the lowering of NAD+ during aging leads to decreased sirtuin activity and may speed up aging processes in laboratory animals and humans. In this study, we used a genetic scr
Externí odkaz:
https://doaj.org/article/1d252bad54af4c79b5877aa6ce62fb6a
Autor:
Melesse Nune, Michael T Morgan, Zaily Connell, Laura McCullough, Muhammad Jbara, Hao Sun, Ashraf Brik, Tim Formosa, Cynthia Wolberger
Publikováno v:
eLife, Vol 8 (2019)
Monoubiquitination of histone H2B (H2B-Ub) plays a role in transcription and DNA replication, and is required for normal localization of the histone chaperone, FACT. In yeast, H2B-Ub is deubiquitinated by Ubp8, a subunit of SAGA, and Ubp10. Although
Externí odkaz:
https://doaj.org/article/0db8b58e52704027aeda985add2f315b
Publikováno v:
bioRxiv
Monoubiquitination of histone H2BK120/123 plays multiple roles in regulating transcription, DNA replication and the DNA damage response. The structure of a nucleosome in complex with the dimeric RING E3 ligase, Bre1, reveals that one RING domain bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec3888293a614f4d82e226a91e5f3d1
https://europepmc.org/articles/PMC10081246/
https://europepmc.org/articles/PMC10081246/
The SAGA (Spt-Ada-Gcn5 acetyltransferase) complex is a transcriptional coactivator that both acetylates and deubiquitinates histones. The histone acetyltransferase (HAT) subunit, Gcn5, is part of a subcomplex of SAGA called the HAT module. A minimal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd71f3c969474b77f30f02345229ea6e
https://doi.org/10.1101/2022.12.29.522244
https://doi.org/10.1101/2022.12.29.522244
Autor:
Sara T. Haile, Sanim Rahman, James K. Fields, Benjamin C. Orsburn, Namandjé N. Bumpus, Cynthia Wolberger
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1866:194929
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eef78d808ecba1c0313104a977403945
https://doi.org/10.1016/j.bbagrm.2023.194929
https://doi.org/10.1016/j.bbagrm.2023.194929
Autor:
Sara T. Haile, Cynthia Wolberger
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00ba0477a8eafaf081b6ecb219965145
https://doi.org/10.1096/fasebj.2022.36.s1.r3974
https://doi.org/10.1096/fasebj.2022.36.s1.r3974
Autor:
Sanim Rahman, Niklas A. Hoffmann, Evan J. Worden, Marissa L. Smith, Kevin E. W. Namitz, Bruce A. Knutson, Michael S. Cosgrove, Cynthia Wolberger
The human Mixed Lineage Leukemia-1 (MLL1) complex orchestrates methylation of histone H3K4 to promote transcription and is stimulated by monoubiquitination of histone H2B. Recent structures of the MLL1-WRAD core complex, which comprises the MLL1 meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef1f91dd5d3d58410e57b13d8b58590
https://doi.org/10.1101/2022.04.04.486905
https://doi.org/10.1101/2022.04.04.486905
Publikováno v:
Cell Chem Biol
The SAGA complex is a transcriptional coactivator that plays multiple roles in activating transcription and is conserved from yeast to humans. One of SAGAs activities is the removal of ubiquitin from histone H2B-K120 by the deubiquitinating module (D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eba28a4863df2afa7551eb45bc8707e
https://europepmc.org/articles/PMC9035043/
https://europepmc.org/articles/PMC9035043/