Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Cynthia, Louis"'
Autor:
Ethan P. Oxley, Nadia J. Kershaw, Cynthia Louis, Katharine J. Goodall, Maximilian M. Garwood, Skye Min Jee Ho, Veronica T.F. Voo, Hae-Young Park, Josephine Iaria, Lilian L.L. Wong, Ariel G. Lebenbaum, Stephanie Wiranata, Ee Shan Pang, Emily S.J. Edwards, Damian B. D’Silva, Jacinta Hansen, Menno C. van Zelm, Meredith O’Keeffe, P. Mark Hogarth, Nicole M. Haynes, Nicholas D. Huntington, Ian P. Wicks, Ross A. Dickins
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114834- (2024)
Summary: T cell surface CTLA4 sequesters the costimulatory ligands CD80 and CD86 on antigen-presenting cells (APCs) to prevent autoimmunity. Therapeutic immunosuppression by recombinant CTLA4-immunoglobulin (Ig) fusion proteins, including abatacept,
Externí odkaz:
https://doaj.org/article/6c8609b2d6c447c2abb2c3c69d1e33ba
Autor:
Timothy Patton, Zhe Zhao, Xin Yi Lim, Eleanor Eddy, Huimeng Wang, Adam G. Nelson, Bronte Ennis, Sidonia B. G. Eckle, Michael N. T. Souter, Troi J. Pediongco, Hui-Fern Koay, Jian-Guo Zhang, Tirta M. Djajawi, Cynthia Louis, Najoua Lalaoui, Nicolas Jacquelot, Andrew M. Lew, Daniel G. Pellicci, James McCluskey, Yifan Zhan, Zhenjun Chen, Kate E. Lawlor, Alexandra J. Corbett
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-11 (2023)
Abstract Cell death mechanisms in T lymphocytes vary according to their developmental stage, cell subset and activation status. The cell death control mechanisms of mucosal-associated invariant T (MAIT) cells, a specialized T cell population, are lar
Externí odkaz:
https://doaj.org/article/32f7d36c0eb7467ba12335d55c4d8b1e
Autor:
Mari Kamiya, Fumitaka Mizoguchi, Kimito Kawahata, Dengli Wang, Masahiro Nishibori, Jessica Day, Cynthia Louis, Ian P. Wicks, Hitoshi Kohsaka, Shinsuke Yasuda
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Polymyositis (PM) is a chronic inflammatory myopathy characterized by progressive muscle weakness. Here the authors showed that muscle fibers in PM undergo necroptosis and aggravate inflammation via releasing pro-inflammatory molecules such as HMGB1.
Externí odkaz:
https://doaj.org/article/5e5ae3df2a554b49bed6089fd7ec2204
Autor:
Dragana Dragoljevic, Man Kit Sam Lee, Gerard Pernes, Pooranee K Morgan, Cynthia Louis, Waled Shihata, Kevin Huynh, Arina A Kochetkova, Patrick W Bell, Natalie A Mellett, Peter J Meikle, Graeme I Lancaster, Michael J Kraakman, Prabhakara R Nagareddy, Beatriz Y Hanaoka, Ian P Wicks, Andrew J Murphy
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 4, Pp n/a-n/a (2023)
Abstract Objectives The leading cause of mortality in patients with rheumatoid arthritis is atherosclerotic cardiovascular disease (CVD). We have shown that murine arthritis impairs atherosclerotic lesion regression, because of cellular cholesterol e
Externí odkaz:
https://doaj.org/article/48c0e47238314555b62510482001ecff
Autor:
Jesse J. Balic, Hassan Albargy, Kevin Luu, Francis J. Kirby, W. Samantha N. Jayasekara, Finbar Mansell, Daniel J. Garama, Dominic De Nardo, Nikola Baschuk, Cynthia Louis, Fiachra Humphries, Katherine Fitzgerald, Eicke Latz, Daniel J. Gough, Ashley Mansell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
TLR4 signalling can reprogram the metabolism of macrophages to be more glycolytic and proinflammatory. Here the authors show that LPS and TLR4 signalling results in recruitment of TBK1, which in turn phosphorylates serine 727 on STAT3 to enable a pro
Externí odkaz:
https://doaj.org/article/56d3ddfe137f4fb1a1f4f01e629a3c2e
Autor:
Elisabeth Mulazzani, Klara Kong, Juan I. Aróstegui, Ashley P. Ng, Nishika Ranathunga, Waruni Abeysekera, Alexandra L. Garnham, Sze-Ling Ng, Paul J. Baker, Jacob T. Jackson, John D. Lich, Margaret L. Hibbs, Ian P. Wicks, Cynthia Louis, Seth L. Masters
Publikováno v:
Nature Immunology. 24:814-826
Missense mutations in PLCG2 can cause autoinflammation with phospholipase C gamma 2-associated antibody deficiency and immune dysregulation (APLAID). Here, we generated a mouse model carrying an APLAID mutation (p.Ser707Tyr) and found that inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3359af22043c30f9c02a487a29c4123d
https://doi.org/10.1038/s41590-023-01473-6
https://doi.org/10.1038/s41590-023-01473-6
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 2, Pp n/a-n/a (2021)
Abstract Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help control local immune responses. Through natural cytotoxicity, production of cytokines and chemokines, and migratory capacity, NK cells play a vi
Externí odkaz:
https://doaj.org/article/5267d08d7b4648849b9976491a429032
Autor:
Katherine R. Balka, Cynthia Louis, Tahnee L. Saunders, Amber M. Smith, Dale J. Calleja, Damian B. D’Silva, Fiona Moghaddas, Maximilien Tailler, Kate E. Lawlor, Yifan Zhan, Christopher J. Burns, Ian P. Wicks, Jonathan J. Miner, Benjamin T. Kile, Seth L. Masters, Dominic De Nardo
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimmune or autoinflammatory disease. Once activated, the cyclic guanosine monophosphate (GMP)-adenosine monophospha
Externí odkaz:
https://doaj.org/article/39c685e669df41c8a1e29b474107e9e0
Autor:
William Sproviero, Yael Elbaz-Alon, Aleksey Shatunov, Chen Eitan, Philip Van Damme, Alfredo Iacoangeli, Ahmad Al Khleifat, CYNTHIA LOUIS, Chien-Hsiung Alan Yu, Johnathan Cooper-Knock, Ashley Jones
Publikováno v:
Nature Neuroscience. 25:433-445
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f40490c52b477ffeaeb940977d3d7b1
https://doi.org/10.1038/s41593-022-01040-6
https://doi.org/10.1038/s41593-022-01040-6
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The pathogenesis of autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is driven by genetic predisposition and environmental triggers that lead to dysregulated immune responses. These include the generation
Externí odkaz:
https://doaj.org/article/9651ab2ec92b44e7aa360ba1075584a3