Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Cynthia, Kenyon"'
Autor:
Antoine Emile Roux, Han Yuan, Katie Podshivalova, David Hendrickson, Rex Kerr, Cynthia Kenyon, David Kelley
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112902- (2023)
Summary: Aging is characterized by a global decline in physiological function. However, by constructing a complete single-cell gene expression atlas, we find that Caenorhabditis elegans aging is not random in nature but instead is characterized by co
Externí odkaz:
https://doaj.org/article/86eb033c73b645c1947c6a7629f7bb5d
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Organisms undergo a variety of characteristic changes as they age, suggesting a substantial commonality in the mechanistic basis of aging. Experiments in model organisms have revealed a variety of cellular systems that impact lifespan, but technical
Externí odkaz:
https://doaj.org/article/3d576617ebdd4db1899e581561ab443e
Autor:
Anaclet Ngabonzima, Cynthia Kenyon, Daniel Kpienbaareh, Isaac Luginaah, Gisele Mukunde, Celestin Hategeka, David F. Cechetto
Publikováno v:
BMC Health Services Research, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background The shortage of health care providers (HCPs) and inequity in their distribution along with the lack of sufficient and equal professional development opportunities in low-income countries contribute to the high mortality and morbid
Externí odkaz:
https://doaj.org/article/e8aedac95c5842d987599082b1f9da37
Autor:
Michelle Chan, Han Yuan, Ilya Soifer, Tobias M Maile, Rebecca Y Wang, Andrea Ireland, Jonathon J O'Brien, Jérôme Goudeau, Leanne JG Chan, Twaritha Vijay, Adam Freund, Cynthia Kenyon, Bryson D Bennett, Fiona E McAllister, David R Kelley, Margaret Roy, Robert L Cohen, Arthur D Levinson, David Botstein, David G Hendrickson
Publikováno v:
eLife, Vol 11 (2022)
The process wherein dividing cells exhaust proliferative capacity and enter into replicative senescence has become a prominent model for cellular aging in vitro. Despite decades of study, this cellular state is not fully understood in culture and eve
Externí odkaz:
https://doaj.org/article/0b19fab21dcc47ebb22236ed22f138ec
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 10, Pp 3623-3638 (2020)
Externí odkaz:
https://doaj.org/article/5a7473eeff8f48f3bdf226cd9bf7c743
Autor:
Anaclet Ngabonzima, Cynthia Kenyon, Celestin Hategeka, Aimee Josephine Utuza, Paulin Ruhato Banguti, Isaac Luginaah, David F Cechetto
Publikováno v:
BMC Health Services Research, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background There are a number of factors that may contribute to high mortality and morbidity of women and newborns in low-income countries. These include a shortage of competent health care providers (HCP) and a lack of sufficient continuous
Externí odkaz:
https://doaj.org/article/aca6839100da469fbc544be062e84bb3
Autor:
Peichuan Zhang, Yuying Zhai, James Cregg, Kenny Kean-Hooi Ang, Michelle Arkin, Cynthia Kenyon
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 2, Pp 849-862 (2020)
Externí odkaz:
https://doaj.org/article/39e0b6cd6f2646268a3528c3b8c7ec9b
Autor:
Madhuja Samaddar, Jérôme Goudeau, Melissa Sanchez, David H Hall, K Adam Bohnert, Maria Ingaramo, Cynthia Kenyon
Publikováno v:
eLife, Vol 10 (2021)
Somatic cells age and die, but the germ-cell lineage is immortal. In Caenorhabditis elegans, germline immortality involves proteostasis renewal at the beginning of each new generation, when oocyte maturation signals from sperm trigger the clearance o
Externí odkaz:
https://doaj.org/article/fc5f2a8480a34f0d98baf157cabd6769
Autor:
Celestin Hategeka, Sandrine Uwisanze, Anaclet Ngabonzima, Oliva Bazirete, Cynthia Kenyon, Domina Asingizwe, Clementine Kanazayire, David Cechetto
Publikováno v:
BMJ Open, Vol 11, Iss 3 (2021)
Objectives To identify mentors’ perspectives on strengths and weaknesses of the Training, Support and Access Model for Maternal, Newborn and Child Health (TSAM-MNCH) clinical mentorship programme in Rwandan district hospitals. Understanding the per
Externí odkaz:
https://doaj.org/article/0f3a194838874066b5932f493ebb92ff
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 441-450 (2017)
Summary: The goal of aging research is to extend healthy, active life. For decades, C. elegans daf-2 insulin/insulin-like growth factor 1 (IGF-1) receptor mutants have served as a model for extended lifespan and youthfulness. However, a recent report
Externí odkaz:
https://doaj.org/article/b0c62b04c91a4944a95b80687bb12c5f