Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Cynthia, Dempsey"'
Autor:
Christine Brandquist, S. Aubrey Stoch, Rose Witter, Cynthia Dempsey, Christopher R. Gibson, Filippos Kesisoglou, Stefan Zajic, Marc L. Reitman, Jeanine E. Ballard, Daria Stypinski, Kelem Kassahun, Anish Mehta
Publikováno v:
The Journal of Clinical Pharmacology. 57:110-117
This open-label 2-period study assessed the effect of multiple-dose administration of rifampin, a strong cytochrome P450 3A (CYP3A) and P-glycoprotein inducer, on the pharmacokinetics of odanacatib, a cathepsin K inhibitor. In period 1, 12 healthy ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e300cabf64e7659f28ba32a7feefb6ea
https://doi.org/10.1002/jcph.780
https://doi.org/10.1002/jcph.780
Autor:
S. Aubrey Stoch, Luzelena Caro, Iain P. Fraser, Xiaoyan Chu, Cynthia Dempsey, Scott Rasmussen, Xiaoxin Cai, Robert Houle, Grace Chan, Prajakti A. Kothare, Stephanie O. Klopfer, Robert Valesky, Raymond Evers, Thomayant Prueksaritanont
Publikováno v:
British Journal of Clinical Pharmacology. 78:587-598
Aims Rosuvastatin and pitavastatin have been proposed as probe substrates for the organic anion-transporting polypeptide (OATP) 1B, but clinical data on their relative sensitivity and selectivity to OATP1B inhibitors are lacking. A clinical study was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abbeedd27a8c3fc075ba548affce4664
https://doi.org/10.1111/bcp.12377
https://doi.org/10.1111/bcp.12377
Autor:
Christine Brandquist, David Hreniuk, Anish Mehta, Bruce DeGroot, Rose Witter, S. Aubrey Stoch, Cynthia Dempsey, Stefan Zajic, Andrew Denker, Daria Stypinski, Chengcheng Liu, John A. Wagner
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 51:688-692
OBJECTIVES This study was conducted in order to assess the effect of multiple doses of odanacatib, a cathepsin (Cat)-K inhibitor, on the pharmacokinetics of digoxin. MATERIALS Twelve healthy male and female subjects received 0.5 mg digoxin and 50 mg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f1e59edb33df2b81fdf2ccae160df4
https://doi.org/10.5414/cp201864
https://doi.org/10.5414/cp201864
Autor:
S Aubrey, Stoch, Jeanine, Ballard, Christopher, Gibson, Filippos, Kesisoglou, Rose, Witter, Kelem, Kassahun, Stefan, Zajic, Anish, Mehta, Christine, Brandquist, Cynthia, Dempsey, Daria, Stypinski, Marc L, Reitman
Publikováno v:
Journal of clinical pharmacology. 57(1)
This open-label 2-period study assessed the effect of multiple-dose administration of rifampin, a strong cytochrome P450 3A (CYP3A) and P-glycoprotein inducer, on the pharmacokinetics of odanacatib, a cathepsin K inhibitor. In period 1, 12 healthy ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0c501d98dd862901e63a1275a9600c8
https://pubmed.ncbi.nlm.nih.gov/27321774
https://pubmed.ncbi.nlm.nih.gov/27321774
Autor:
Thomayant, Prueksaritanont, Xiaoyan, Chu, Raymond, Evers, Stephanie O, Klopfer, Luzelena, Caro, Prajakti A, Kothare, Cynthia, Dempsey, Scott, Rasmussen, Robert, Houle, Grace, Chan, Xiaoxin, Cai, Robert, Valesky, Iain P, Fraser, S Aubrey, Stoch
Publikováno v:
British journal of clinical pharmacology. 78(3)
Rosuvastatin and pitavastatin have been proposed as probe substrates for the organic anion-transporting polypeptide (OATP) 1B, but clinical data on their relative sensitivity and selectivity to OATP1B inhibitors are lacking. A clinical study was ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::201f43fa6b85cf167836c452397d361e
https://pubmed.ncbi.nlm.nih.gov/24617605
https://pubmed.ncbi.nlm.nih.gov/24617605