Výsledky vyhledávání - "Cynthia, Boehm"

Influence of Glucose Concentration on Colony-Forming Efficiency and Biological Performance of Primary Human Tissue–Derived Progenitor Cells

Autor: Wes A Bova, Ryan Kaplevatsky, Cynthia Boehm, Ronald J. Midura, Venkata P. Mantripragada, Nancy A. Obuchowski, George F. Muschler

Publikováno v: Cartilage

Objective Glucose concentrations used in current cell culture methods are a significant departure from physiological glucose levels. The study focuses on comparing the effects of glucose concentrations on primary human progenitors (connective tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7bcd379fc90452d0838b1389714bc2
https://doi.org/10.1177/1947603520906605

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Native-Osteoarthritic Joint Resident Stem and Progenitor Cells for Cartilage Cell-Based Therapies: A Quantitative Comparison With Respect to Concentration and Biological Performance

Autor: Wes A Bova, Nicolas S. Piuzzi, Cynthia Boehm, Nancy A. Obuchowski, George F. Muschler, Venkata P. Mantripragada, Ronald J. Midura

Publikováno v: The American Journal of Sports Medicine. 47:3521-3530

Background:Cell-based therapy for cartilage repair is a promising approach and is becoming an established technique. Yet, there is no consensus on the optimal cell source.Purpose:To provide a donor-matched quantitative comparison of the connective ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32a1f671c5d2aac7ec1f2c5b90fe6e4
https://doi.org/10.1177/0363546519880905

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Reliable assessment of bone marrow and bone marrow concentrates using automated hematology analyzer

Autor: Mitchell Ng, George F. Muschler, Nicolas S. Piuzzi, Cynthia Boehm, Venkata P. Mantripragada, Wesley Bova, Jaiben George

Publikováno v: Regen Med

Aim: A limiting factor in advancement of bone marrow based cell therapies is the lack of characterization of cell products delivered to patients. Methods: Using an automated hematology analyzer that can be implemented in clinical setting, the composi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca9abd29adb6e4a75ea88e0f071e99a
https://doi.org/10.2217/rme-2018-0173

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Patient Age and Cell Concentration Influence Prevalence and Concentration of Progenitors in Bone Marrow Aspirates: An Analysis of 436 Patients

Autor: Isaac Briskin, Venkata P. Mantripragada, George F. Muschler, Wesley Bova, Nicolas S. Piuzzi, Cynthia Boehm

Publikováno v: The Journal of bone and joint surgery. American volume. 103(17)

Connective tissue progenitors (CTPs) resident in native tissues serve as biological building blocks in tissue repair and remodeling processes. Methods for analysis and reporting on CTP quantity and quality are essential for defining optimal cell sour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848200459a775fb50676cfc06d490ead
https://pubmed.ncbi.nlm.nih.gov/33844657

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Variation in primary and culture-expanded cells derived from connective tissue progenitors in human bone marrow space, bone trabecular surface and adipose tissue

Autor: Ronald J. Midura, Wesley Bova, Christopher Malcuit, Maha A. Qadan, Vincent C. Hascall, Malcolm Moos, Nicolas S. Piuzzi, Cynthia Boehm, George F. Muschler

Publikováno v: Cytotherapy. 20:343-360

Background aims Connective tissue progenitors (CTPs) embody the heterogeneous stem and progenitor cell populations present in native tissue. CTPs are essential to the formation and remodeling of connective tissue and represent key targets for tissue-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c1422a4259c821b5ff343a211385cb
https://doi.org/10.1016/j.jcyt.2017.11.013

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Assessment of Clinical, Tissue, and Cell-Level Metrics Identify Four Biologically Distinct Knee Osteoarthritis Patient Phenotypes

Autor: Venkata P. Mantripragada, Alexander Csorba, Wesley Bova, Cynthia Boehm, Nicolas S. Piuzzi, Jennifer Bullen, Ronald J. Midura, George F. Muschler

Publikováno v: CARTILAGE. 13:194760352210740

Objective Clinical heterogeneity of primary osteoarthritis (OA) is a major challenge in understanding pathogenesis and development of targeted therapeutic strategies. This study aims to (1) identify OA patient subgroups phenotypes and (2) determine p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eefc4fe6d2cb48edcf4e4188fb320f87
https://doi.org/10.1177/19476035221074003

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Progenitor cells from different zones of human cartilage and their correlation with histopathological osteoarthritis progression

Autor: Venkata P. Mantripragada, Nancy A. Obuchowski, George F. Muschler, Nicolas S. Piuzzi, Cynthia Boehm, Wesley Bova, Ronald J. Midura

Publikováno v: Journal of Orthopaedic Research®. 36:1728-1738

Cell-based therapies development for the treatment of osteoarthritis (OA) requires an understanding of the disease progression and attributes of the cells resident in cartilage. This study focused on quantitative assessment of the concentration and b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be7faf256594f5451ef33f87998ef3cf
https://doi.org/10.1002/jor.23829

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Palovarotene inhibits connective tissue progenitor cell proliferation in a rat model of combat‐related heterotopic ossification

Autor: Allison M. Tomasino, Jonathan A. Forsberg, Devaveena Dey, Benjamin M Wheatley, Cynthia Boehm, Wesley Bova, Masahiro Iwamoto, Thomas A. Davis, Erin M. Sanders, Benjamin K. Potter, George F. Muschler, Katherine E. Cilwa, Ammar T. Qureshi, Jonathan G. Seavey

Publikováno v: Journal of Orthopaedic Research. 36:1135-1144

Heterotopic ossification (HO) develops in the extremities of wounded service members and is common in the setting of high-energy penetrating injuries and blast-related amputations. No safe and effective prophylaxis modality has been identified for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa159610b747602048906ca26c924aa
https://doi.org/10.1002/jor.23747

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Integrated Colony Imaging, Analysis, and Selection Device for Regenerative Medicine

Autor: Thomas R. Adams, James Dunn, Edward Kwee, Cynthia Boehm, George F. Muschler, Frank Krakosh, Kimerly A. Powell, Edward E. Herderick, James Monnich, Robert Germanowski

Publikováno v: SLAS Technology. 22:217-223

Stem and progenitor cells derived from human tissues are being developed as cell sources for cell-based assays and therapies. However, tissue-derived stem and progenitor cells are heterogeneous. Differences in observed clones of stem cells likely ref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931705d8f054ef5915d1f5b4046e960b
https://doi.org/10.1177/2211068216676587

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