Výsledky vyhledávání - "Cymbelene Nardo"

Development of an automated mass spectrometry system for the quantitative analysis of liver microsomal incubation samples: a tool for rapid screening of new compounds for metabolic stability

Autor: Diane E. Grotz, Kimberly Dunn-Meynell, Eva Duchoslav, Kathleen Cox, Chin-Chung Lin, Chris Elicone, Charles C. Liu, Cynthia A. Palmer, Cymbelene Nardo, Walter A. Korfmacher

Publikováno v: Rapid Communications in Mass Spectrometry. 13:901-907

There is a continuing need for increased throughput in the evaluation of new drug entities in terms of their pharmacokinetic parameters. One useful parameter that can be measured in vitro using liver microsomal preparations is metabolic stability. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0cca7ca8006af11ba2776b1fb57b5f26
https://doi.org/10.1002/(sici)1097-0231(19990530)13:10<901::aid-rcm583>3.0.co

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Inhibitors of Farnesyl Protein Transferase. 4-Amido, 4-Carbamoyl, and 4-Carboxamido Derivatives of 1-(8-Chloro-6,11-dihydro-5H-benzo[5,6]- cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-Bromo-8-chloro-6,11- dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine

Publikováno v: Journal of Medicinal Chemistry. 41:877-893

The synthesis of a variety of novel 4-amido, 4-carbamoyl and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine to explore the SAR of of this series of FPT inhibitors is described. This result

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a59be9fe019a7f862971d75f795692d9
https://doi.org/10.1021/jm970462w

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Pharmacokinetic screening for the selection of new drug discovery candidates is greatly enhanced through the use of liquid chromatography–atmospheric pressure ionization tandem mass spectrometry

Autor: Shiyong Wang, Walter A. Korfmacher, Cymbelene Nardo, Chin-Chung Lin, Matthew Bryant, Amin A. Nomeir

Publikováno v: Journal of Chromatography A. 777:61-66

Selection of a new drug discovery candidate from a series of compounds requires a means of performing rapid analytical method development and sensitive quantitation of each drug in serum, plasma or other biological matrices. Information on serum/plas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036250b453d12153d686e860fcbbac5a
https://doi.org/10.1016/s0021-9673(97)00561-x

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The synthesis and structure-activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists

Autor: Cymbelene Nardo, Shirley M. Williams, Maria A. Rivelli, Leonard Favreau, Joe F. Lee, John A. Hey, John C. Anthes, Margaret M. Albanese, Robert G. Aslanian, Jie Wu, Walter A. Korfmacher, Michel R. Corboz, Robert E. West, Pauline C. Ting

Publikováno v: Bioorganicmedicinal chemistry letters. 20(17)

A structure–activity relationship study of the lead piperazinylcarbonylpiperidine compound 3 resulted in the identification of 4-benzimidazolyl-piperidinylcarbonyl-piperidine 6h as a histamine-3 (H3) receptor antagonist. Additional optimization of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97224cffd70d84d39fe86aed3c6d61e2
https://pubmed.ncbi.nlm.nih.gov/20685118

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Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists

Publikováno v: Bioorganicmedicinal chemistry letters. 16(4)

A novel series of histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine template displaying low CYP2D6 and CYP3A4 inhibitory profiles has been identified. Structural features responsible for the reduction of P450 activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a814e6db74d99482879e523c21e4d8
https://pubmed.ncbi.nlm.nih.gov/16297617

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Erratum to 'Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists' [Bioorg. Med. Chem. Lett. 16 (2006) 989–994]

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:3342

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e34ebcf10498a2bb393a4ad72c5322e3
https://doi.org/10.1016/j.bmcl.2006.01.096

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