Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Cyf Ramos-Colon"'
Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism
Autor:
Yeon Sun Lee, Michael Remesic, Cyf Ramos-Colon, Zhijun Wu, Justin LaVigne, Gabriella Molnar, Dagmara Tymecka, Aleksandra Misicka, John M. Streicher, Victor J. Hruby, Frank Porreca
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 625 (2021)
In our previous studies, we developed a series of mixed MOR/DOR agonists that are enkephalin-like tetrapeptide analogs with an N-phenyl-N-piperidin-4-ylpropionamide (Ppp) moiety at the C-terminus. Further SAR study on the analogs, initiated by the fi
Externí odkaz:
https://doaj.org/article/5b6b2c3eba6f414bbf633d9023f2ac2b
Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism
Autor:
Michael Remesic, John M. Streicher, Zhijun Wu, Gabriella Molnar, Victor J. Hruby, Frank Porreca, Yeon Sun Lee, Justin LaVigne, Aleksandra Misicka, Cyf Ramos-Colon, Dagmara Tymecka
Publikováno v:
Biomedicines, Vol 9, Iss 625, p 625 (2021)
Biomedicines
Volume 9
Issue 6
Biomedicines
Volume 9
Issue 6
In our previous studies, we developed a series of mixed MOR/DOR agonists that are enkephalin-like tetrapeptide analogs with an N-phenyl-N-piperidin-4-ylpropionamide (Ppp) moiety at the C-terminus. Further SAR study on the analogs, initiated by the fi
Autor:
Frank Porreca, John M. Streicher, Jessica Hanson, Tally M. Largent-Milnes, Peg Davis, Alexander J. Sandweiss, Todd W. Vanderah, Sara M. Hall, Victor J. Hruby, Cyf Ramos-Colon, Justin LaVigne, Yeon Sun Lee, Mary I. McIntosh, Michael Remesic
Publikováno v:
Journal of Medicinal Chemistry. 59:10291-10298
Dynorphin A (Dyn A) is an endogenous ligand for the opioid receptors with preference for the κ opioid receptor (KOR), and its structure-activity relationship (SAR) has been extensively studied at the KOR to develop selective potent agonists and anta
Autor:
Frank Porreca, David Rankin, Alexander Kuzmin, Josephine Lai, Michael Remesic, Victor J. Hruby, Sara M. Hall, Cyf Ramos-Colon, Yeon Sun Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5513-5516
Nerve injury and inflammation cause up-regulation of an endogenous opioid ligand, dynorphin A (Dyn A), in the spinal cord resulting in hyperalgesia via the interaction with bradykinin receptors (BRs). This is a non-opioid neuroexcitatory effect that
Autor:
Frank Porreca, Chaoling Qu, Lindsay LeBaron, Yeon Sun Lee, Cyf Ramos-Colon, Victor J. Hruby, Jennifer Y. Xie, Sara M. Hall, Josephine Lai
Publikováno v:
ACS Chemical Neuroscience. 7:1746-1752
Dynorphin A (Dyn A) is a unique endogenous ligand that possesses well-known neuroinhibitory effects via opioid receptors with a preference for the kappa receptor but also neuroexcitatory effects, which cause hyperalgesia. We have shown that the neuro
Autor:
Frank Porreca, Victor J. Hruby, Michael Remesic, Christopher Chan, David Rankin, Cyf Ramos-Colon, Yeon Sun Lee, Robert Kupp, Sara M. Hall, Josephine Lai
Publikováno v:
Chemical Biology & Drug Design. 88:615-619
As a unique endogenous opioid ligand, dynorphin A shows paradoxical neuroexcitatory effects at bradykinin receptors, and the effects are known to be amplified by the upregulation of dynorphin A under chronic pain and inflammatory conditions. In our e
Publikováno v:
Proceedings of the 35th European Peptide Symposium.
Publikováno v:
Proceedings of the 35th European Peptide Symposium.
Publikováno v:
Proceedings of the 35th European Peptide Symposium.
Autor:
Ann Nguyen, Michael Remesic, Frank Porreca, Victor J. Hruby, David Rankin, Cyf Ramos-Colon, Lindsay LeBaron, Yeon Sun Lee, Sara M. Hall, Josephine Lai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:30-33
It has been shown that under chronic pain or nerve injury conditions, up-regulated dynorphin A (Dyn A) interacts with bradykinin receptors (BRs) to cause hyperalgesia in the spinal cord. Thus BRs antagonist can modulate hyperalgesia by blocking Dyn A