Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor

Autor: Graeme Milligan, Sunil K. Pandey, Brian D. Hudson, Amanda E. Mackenzie, Irina G. Tikhonova, Elisabeth Christiansen, Hannah Murdoch, Maria E Due-Hansen, Trond Ulven, Anna Mette Hansen, Richard J. Ward, Rudi Marquez

Publikováno v: The Journal of Biological Chemistry
Hudson, B D, Due-Hansen, M E, Christiansen, E, Hansen, A M, Mackenzie, A E, Murdoch, H, Pandey, S K, Ward, R J, Marquez, R, Tikhonova, I G, Ulven, T & Milligan, G 2013, ' Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor ', Journal of Biological Chemistry, vol. 288, no. 24, pp. 17296-17312 . https://doi.org/10.1074/jbc.M113.455337
Hudson, B D, Due-Hansen, M E, Christiansen, E, Hansen, A, Mackenzie, A E, Murdoch, H, Pandey, S K, Ward, R J, Marquez, R, Tikhonova, I G, Ulven, T & Milligan, G 2013, ' Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor ', Journal of Biological Chemistry, vol. 288, pp. 17296-17312 . https://doi.org/10.1074/jbc.M113.455337

Background: Understanding the function of FFA2 has been slowed by a lack of selective orthosteric ligands. Results: Residues within FFA2 that dictate the recognition and function of potent and selective orthosteric agonists are described. Conclusion:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc95593b410c8497ec6ceed8e3f6d972
https://pubmed.ncbi.nlm.nih.gov/23589301