Enantioselective Cascade Biocatalysis for Deracemization of Racemic β‐Amino Alcohols to Enantiopure ( S )‐β‐Amino Alcohols by Employing Cyclohexylamine Oxidase and ω‐Transaminase

Autor: Honghong Chang, Jing Li, Chaofeng Zhang, Li-Li Gao, Ya-Wen Chang, Rui Dong, Xiao-Xiao Yang, Shuangping Huang, Xing-Mei Guo, Jian-Dong Zhang

Publikováno v: ChemBioChem. 22:124-128

Optically active β-amino alcohols are very useful chiral intermediates frequently used in the preparation of pharmaceutically active substances. Here, a novel cyclohexylamine oxidase (ArCHAO) was identified from the genome sequence of Arthrobacter s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb755591185b1c2f85426e875905dd9d
https://doi.org/10.1002/cbic.202000491

Ultrahigh-throughput screening enables efficient single-round oxidase remodelling

Autor: Lukas Friedrich, Andrew D. Griffiths, Richard Obexer, Donald Hilvert, Moritz Pott, Anthony P. Green, Aaron Debon

Publikováno v: Debon, A, Pott, M, Obexer, R, Green, A, Friedrich, L, Griffiths, A D & Hilvert, D 2019, ' Ultrahigh-Throughput Screening Enables Efficient Single-Round Oxidase Remodeling ', Nature Catalysis . https://doi.org/10.1038/s41929-019-0340-5

Biocatalysis provides a potentially sustainable means of chemical manufacturing. However, the tailoring of enzymes to industrial processes is often laborious and time consuming, which limits the broad implementation of this approach. High-throughput

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96cea3b23794210cebe555df5d146b3
https://doi.org/10.1038/s41929-019-0340-5

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Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines

Autor: Stephen P. Marsden, Nicholas J. Turner, Shahed Hussain, Sebastian C. Cosgrove

Publikováno v: ACS Catalysis. 8:5570-5573

The power of complementary chemocatalytic and biocatalytic transformations is demonstrated in the asymmetric synthesis of 2-substituted tetrahydroquinolines. A series of racemic tetrahydroquinolines were synthesized through a convergent one-pot Rh(I)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36e22ac22e29d0c37e02053b197cbd81
https://doi.org/10.1021/acscatal.8b01220

Biocatalytic Route to Chiral 2-Substituted-1,2,3,4-Tetrahydroquinolines Using Cyclohexylamine Oxidase Muteins

Autor: Peter C. K. Lau, Peiqian Cong, Dunming Zhu, Jinlong Li, Guangyue Li, Jie Ren, Jianping Lin, Peiyuan Yao, Rui Gong, Jinhui Feng, Qiaqing Wu

Publikováno v: ACS Catalysis. 8:1648-1652

Chiral 2-substituted-1,2,3,4-tetrahydroquinolines (2-substituted-THQs) can serve as invaluable building blocks for certain pharmaceutical agents. This study was conducted to expand the biocatalytic repertoire of a bacterial cyclohexylamine oxidase (C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::371be44c665082ac07799b531c86ffb1
https://doi.org/10.1021/acscatal.7b03552