Zobrazeno 1 - 10
of 660
pro vyhledávání: '"Cycloguanil"'
Autor:
Agede O. Ayodele, Ogunmodede J. Ayodele, Sanni Nasiru, Wasagu I. Musa, Oyedepo Dapo Sunday, Aiyedun Olawale Stephen, Falade C. Olufunke
Publikováno v:
Journal of Tropical Pharmacy and Chemistry, Vol 8, Iss 1 (2024)
Pharmacophore Enhanced Shape Alignment (PheSA) compares the similarities of compounds based on their pharmacophoric and geometrical characteristics. Ligand efficiency is a notion used to maximize the potency and effectiveness of medication candidates
Externí odkaz:
https://doaj.org/article/ae17e26608324abb83054cd3868fa099
Publikováno v:
Pharmaceuticals, Vol 17, Iss 9, p 1234 (2024)
N-methyl-D-aspartate (NMDA) receptors are inhibited by many medicinal drugs. The recent successful repurposing of NMDA receptor antagonists ketamine and dextromethorphan for the treatment of major depressive disorder further enhanced the interest in
Externí odkaz:
https://doaj.org/article/cbc20e37ce1149388170420e65f49317
Autor:
Zakari Ya'u Ibrahim, Adamu Uzairu, Gideon Adamu Shallangwa, Stephen Eyije Abechi, Sulaiman Isyaku
Publikováno v:
Chemical Physics Impact, Vol 5, Iss , Pp 100132- (2022)
ABSTRACT: The increasing resistance of the malarial parasite to readily available drugs ensures a continuous battle against endemic diseases. Hence, the search for antimalarial drugs with enhanced activity against the P. falciparum strain becomes an
Externí odkaz:
https://doaj.org/article/29ff73b9450940bfb20fbe863e57dad9
Akademický článek
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Publikováno v:
Indonesian Journal of Chemistry, Vol 21, Iss 1, Pp 66-76 (2020)
Malaria is a disease that commonly infects humans in many tropical areas. This disease becomes a serious problem because of the high resistance of Plasmodium parasite against the well-established antimalarial agents, such as Artemisinin. Hence, new p
Externí odkaz:
https://doaj.org/article/1220470c3ccd4ae295d5dcc241042823
Autor:
Jennifer I. Brown, Peng Wang, Alan Y. L. Wong, Boryana Petrova, Rosanne Persaud, Sepideh Soukhtehzari, Melanie Lopez McDonald, Danielle Hanke, Josephine Christensen, Petar Iliev, Weiyuan Wang, Daniel K. Everton, Karla C. Williams, David A. Frank, Naama Kanarek, Brent D. G. Page
Publikováno v:
Metabolites, Vol 13, Iss 2, p 151 (2023)
Dihydrofolate reductase (DHFR) is an established anti-cancer drug target whose inhibition disrupts folate metabolism and STAT3-dependent gene expression. Cycloguanil was proposed as a DHFR inhibitor in the 1950s and is the active metabolite of clinic
Externí odkaz:
https://doaj.org/article/dc113ce5c5ce4058bae4c79c8ea7ac25
Autor:
Maarten van der Velden, Albert Bilos, Jeroen J. M. W. van den Heuvel, Sanna R. Rijpma, Evelien G. E. Hurkmans, Robert W. Sauerwein, Frans G. M. Russel, Jan B. Koenderink
Publikováno v:
Malaria Journal, Vol 16, Iss 1, Pp 1-12 (2017)
Abstract Background Malaria, HIV/AIDS, and tuberculosis endemic areas show considerable geographical overlap, leading to incidence of co-infections. This requires treatment with multiple drugs, potentially causing adverse drug–drug interactions (DD
Externí odkaz:
https://doaj.org/article/b27f86145f49479db057cc1f0f96e3c4
Autor:
Sirawaraporn, Worachart, Sathitkul, Tanajit, Sirawaraporn, Rachada, Yuthavong, Yongyuth, Santi, Daniel V.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1997 Feb . 94(4), 1124-1129.
Externí odkaz:
https://www.jstor.org/stable/41295
Autor:
Giusy Tassone, Giacomo Landi, Pasquale Linciano, Valeria Francesconi, Michele Tonelli, Lorenzo Tagliazucchi, Maria Paola Costi, Stefano Mangani, Cecilia Pozzi
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 636 (2021)
Trypanosoma and Leishmania parasites are the etiological agents of various threatening neglected tropical diseases (NTDs), including human African trypanosomiasis (HAT), Chagas disease, and various types of leishmaniasis. Recently, meaningful progres
Externí odkaz:
https://doaj.org/article/70e738fa89394bc7959ea50a78f26d41
Akademický článek
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