Výsledky vyhledávání - "Cyclin-Dependent Kinase Inhibitor p27/metabolism"

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Autor: Alberto J. Arribas, Abdullah Alajati, Letizia Gnetti, Andrea Alimonti, Hermeto Gerber, Mitko Dimitrov, Ajinkya Revandkar, Maria Luna Perciato, Sandra Pinton, Nicolas Delaleu, Andrea Rinaldi, Marco Losa, Patrick C. Fraering, Emiliano Pasquini, Francesco Bertoni, Alain Nepveu, Alberto Toso, Rocco D'Antuono, Jingjing Chen

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature communications, vol. 7, pp. 13719
Nature Communications
Nature Communications, 7 (1)

Activation of NOTCH signalling is associated with advanced prostate cancer and treatment resistance in prostate cancer patients. However, the mechanism that drives NOTCH activation in prostate cancer remains still elusive. Moreover, preclinical evide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9ffecf0c4ef0986b4e64d57668dae3
https://doaj.org/article/ea3cbc2df78f4176a7c391021d800478

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Deregulation of anti-Mullerian hormone/BMP and transforming growth factor- pathways in Leydig cell lesions developed in male heterozygous multiple endocrine neoplasia type 1 mutant mice

Autor: Séverine Mazaud Guittot, Sandra Fontanière, Alain Calender, Nader Hussein, Anne-Marie Morera, Nathalie di Clemente, Huguette Casse, Jieli Lu, Chang X. Zhang

Publikováno v: Endocrine-Related Cancer
Endocrine-Related Cancer, BioScientifica, 2008, 15 (1), pp. 217-27. ⟨10.1677/ERC-06-0046⟩

International audience; Multiple endocrine neoplasia type 1 (MEN1) results from the mutation of the predisposing gene, MEN1. Heterozygous Men1 mutant mice previously generated by several laboratories, including ours, mimic largely MEN1 pathology. Int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6663f7a483228b6087407961dd721d71
https://doi.org/10.1677/erc-06-0046

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The pleiotropic effect of TRAIL on tumor-like synovial fibroblasts from rheumatoid arthritis patients is mediated by caspases

Autor: R. Audo, Jacques Morel, Bernard Combe, B Coulet, Michael Hahne

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2009, 16 (9), pp.1227--37. ⟨10.1038/cdd.2009.38⟩

The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has gained much attention as a possible therapeutic reagent for the treatment of tumors, as TRAIL was originally described to induce apoptosis specifically in cancer cells, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9104f0b2262fb56689993e62258b7993
https://hal.archives-ouvertes.fr/hal-02194088

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HSV-1 Cgal+ Infection Promotes Quaking RNA Binding Protein Production and Induces Nuclear-Cytoplasmic Shuttling of Quaking I-5 Isoform in Human Hepatoma Cells

Autor: Jean-Charles Sanchez, Fernando J. Corrales, Anna Greco, Alberto L. Epstein, Enrique Santamaría, Loïc Dayon, Virginia Sánchez-Quiles, Maria Giovanna Foschini, María I. Mora, Victor Segura, Jesús Prieto

Publikováno v: Molecular and Cellular Proteomics, Vol. 10, No 6 (2011) P. M111.009126

Herpesvirus type 1 (HSV-1) based oncolytic vectors arise as a promising therapeutic alternative for neoplastic diseases including hepatocellular carcinoma. However, the mechanisms mediating the host cell response to such treatments are not completely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78385053d542e26e3669a9d8cf94f234
https://doi.org/10.1074/mcp.m111.009126

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