Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Cyclin-Dependent Kinase Inhibitor p16/genetics"'
1
Durable response to palbociclib and letrozole in ovarian cancer withCDKN2Aloss
Autor: Sophie Clément, Pierre O. Chappuis, Alexandre Bodmer, Krisztian Homicsko, Yann Christinat, Melinda Charrier, Olivier Michielin, Petros Tsantoulis, Daniele Frisone, Thomas Alexander Mckee, Laure Thouvenin
Publikováno v: Cancer biology & therapy, vol. 21, no. 3, pp. 197-202
Cancer Biology and Therapy, Vol. 21, No 3 (2020) pp. 197-202
Alterations of the Retinoblastoma (Rb) pathway are frequent in ovarian cancer, typically resulting from CDKN2A down-regulation, CCNE1 amplification, CCND1/2 amplification, and RB1 loss. However, bi-allelic CDKN2A mutation or homozygous deletion is a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352c882e2c41b9625dab34c1f829ff27
https://doi.org/10.1080/15384047.2019.1685291
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2
Cdkn2a deficiency promotes adipose tissue browning
Autor: Rabhi, N., Hannou, S.A., Gromada, X., Salas, E., Yao, X., Oger, F., Carney, C., Lopez-Mejia, I.C., Durand, E., Rabearivelo, I., Bonnefond, A., Caron, E., Fajas, L., Dani, C., Froguel, P., Annicotte, J.S.
Publikováno v: Molecular Metabolism, Vol 8, Iss, Pp 65-76 (2018)
Molecular Metabolism
Molecular metabolism, vol. 8, pp. 65-76
Objectives Genome-wide association studies have reported that DNA polymorphisms at the CDKN2A locus modulate fasting glucose in human and contribute to type 2 diabetes (T2D) risk. Yet the causal relationship between this gene and defective energy hom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::090c3400938126ef2f38db039b2821ba
http://www.sciencedirect.com/science/article/pii/S2212877817309353
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3
Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus
Autor: Anna Griego, Francesco Aulicino, Antonio del Sol, Aniello Cerrato, Maria Pia Cosma, Gökhan Ertaylan, Anchel de Jaime-Soguero, Frederic Lluis, Aravind Tallam
Publikováno v: PLoS Genetics, Vol 13, Iss 3, p e1006682 (2017)
PLOS genetics (Online) 13 (2017). doi:10.1371/journal.pgen.1006682
info:cnr-pdr/source/autori:De Jaime-Soguero A.; Aulicino F.; Ertaylan G.; Griego A.; Cerrato A.; Tallam A.; del Sol A.; Cosma M.P.; Lluis F./titolo:Wnt%2FTcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4%2FArf locus/doi:10.1371%2Fjournal.pgen.1006682/rivista:PLOS genetics (Online)/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:13
PLoS Genetics
Recercat. Dipósit de la Recerca de Catalunya
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Plos Genetics, 13(3):e1006682. Public Library of Science
De Jaime-Soguero, A, Aulicino, F, Ertaylan, G, Griego, A, Cerrato, A, Tallam, A, Del Sol, A, Cosma, M P & Lluis, F 2017, ' Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus ', PLoS Genetics, vol. 13, no. 3, e1006682 . https://doi.org/10.1371/journal.pgen.1006682
Understanding the mechanisms regulating cell cycle, proliferation and potency of pluripotent stem cells guarantees their safe use in the clinic. Embryonic stem cells (ESCs) present a fast cell cycle with a short G1 phase. This is due to the lack of e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0baf0be0d381ed144c662e251481d377
https://lirias.kuleuven.be/handle/123456789/629757
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4
Comprehensive Field Synopsis and Systematic Meta-analyses of Genetic Association Studies in Cutaneous Melanoma
Autor: George M. Spyrou, Johannes T. Roehr, Vasiliki Nicolaou, Elizabeth Kodela, Andreas Katsambas, Evangelos Evangelou, Foteini Chatzinasiou, Katerina P. Kypreou, Christina M. Lill, John P. A. Ioannidis, I. Stefanaki, Hensin Tsao, Lars Bertram, Alexander J. Stratigos
Publikováno v: JNCI Journal of the National Cancer Institute. 103:1227-1235
BACKGROUND: Although genetic studies have reported a number of loci associated with cutaneous melanoma (CM) risk, a comprehensive synopsis of genetic association studies published in the field and systematic meta-analysis for all eligible polymorphis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1df31dfaea6e19807071d69647c3c57
https://doi.org/10.1093/jnci/djr219
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5
Pancreatic cancer-associated gene polymorphisms in a nation-wide cohort of p16-Leiden germline mutation carriers; a case-control study
Autor: Thomas P. Potjer, Jeanine J. Houwing-Duistermaat, Frederik J. Hes, Hans F. A. Vasen, Charlotte J. Dommering, Ingrid C. Konings, Margreet G. E. M. Ausems, Peter C. van den Akker, Liesbeth Spruijt, Merel C. Maiburg, Nienke van der Stoep, Cora M. Aalfs, Anja Wagner, Lizet E. van der Kolk
Publikováno v: BMC Research Notes, 8, pp. 264
BMC Research Notes, 8:264. BioMed Central
BMC Research Notes, 8:264. BioMed Central Ltd.
Potjer, T P, van der Stoep, N, Houwing-Duistermaat, J J, Konings, I C A W, Aalfs, C M, van den Akker, P C, Ausems, M G, Dommering, C J, van der Kolk, L E, Maiburg, M C, Spruijt, L, Wagner, A, Vasen, H F A & Hes, F J 2015, ' Pancreatic cancer-associated gene polymorphisms in a nation-wide cohort of p16-Leiden germline mutation carriers; a case–control study ', BMC Research Notes, vol. 8, 264 . https://doi.org/10.1186/s13104-015-1235-4
BMC Research Notes, 8, 264
BMC Research Notes
BMC research notes, 8. BioMed Central
Contains fulltext : 153585.pdf (Publisher’s version ) (Open Access) BACKGROUND: The p16-Leiden founder mutation in the CDKN2A gene is the most common cause of Familial Atypical Multiple Mole Melanoma (FAMMM) syndrome in the Netherlands. Individuals
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc2f8760b3dc0009a1382818f27e069
https://hdl.handle.net/2066/153585
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7
Prognostic molecular markers with no impact on decision-making: the paradox of gliomas based on a prospective study
Autor: Pierre Levillain, C.J. Larsen, Lucie Karayan-Tapon, Joelle Guilhot, Philippe Rigoard, Philippe Menei, Serge Milin, J.-L. Blanc, F. Duthe, B. Bataille, F. Lapierre, Dominique Bonneau, Sophie Michalak, Michel Wager
Publikováno v: British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2008, 98 (11), pp.1830-8. ⟨10.1038/sj.bjc.6604378⟩
International audience; This study assessed the prognostic value of several markers involved in gliomagenesis, and compared it with that of other clinical and imaging markers already used. Four-hundred and sixteen adult patients with newly diagnosed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09baa4fa38fc88ce8011553117da9f77
https://pubmed.ncbi.nlm.nih.gov/18506188
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