Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Cyclin binding"'
Publikováno v:
Physical Chemistry Chemical Physics. 22:25474-25482
HIV is a virus that attacks the T cells. HIV may either actively replicate or become latent within host cells for years. Since HIV uses its own protein Tat to hijack the host CDK9-Cyclin complex for transcription, Tat is implicated in transcription-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f48ef8b0b6be17197b6d95933e47c3
https://doi.org/10.1039/d0cp03662e
https://doi.org/10.1039/d0cp03662e
Autor:
Diwakar Shukla, Zahra Shamsi
Publikováno v:
Molecular Systems Design & Engineering. 5:392-400
Evolution has altered the free energy landscapes of protein kinases to introduce different regulatory switches and modify their catalytic functions. In this work, we demonstrate how cyclin dependency has emerged in cyclin-dependent kinases (CDKs) by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ebd9d84050a36b72caa825c3237a884
https://doi.org/10.1039/c9me00097f
https://doi.org/10.1039/c9me00097f
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
The active site of the essential, eukaryotic CDK1 kinase is generated by core structural elements, among which the PSTAIRE motif in the critical αC-helix, is universally conserved in metazoans. The CDK2 kinase, sharing the PSTAIRE, arose early in me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9385e52614773f1cc7938a4cd94cf32
https://hdl.handle.net/11250/3037760
https://hdl.handle.net/11250/3037760
Autor:
Li Ren, Xuemei Zhao, Xing Wang, Mingjun Gu, Hongling Zhu, Lianyong Liu, Shuanggang Hu, Junhua Ma, Zhaohui Zhu, Xiangqi Li, Chaobao Zhang, Chao Shi
Publikováno v:
Experimental and Therapeutic Medicine
Type 2 taste receptor 10 (TAS2R10), belonging to the TAS2R family of bitter receptors, is widely expressed in extra-oral tissues. However, its biological roles beyond bitterness sensing in the tongue have remained largely elusive. The present study a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c99729fa95346570417681a1ea225d
http://europepmc.org/articles/PMC7027137
http://europepmc.org/articles/PMC7027137
Autor:
Lantao Wang, Xin Wang
Publikováno v:
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
BACKGROUND Alzheimer's disease (AD) is the leading cause of dementia worldwide; however, the molecular mechanisms underlying its pathogenesis remain unclear. The present study aimed to discover some potential peripheral blood biomarkers for early det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fdbdb5dbd4cbb50c9e8b6245d0084b
https://doi.org/10.12659/msm.924263
https://doi.org/10.12659/msm.924263
Publikováno v:
Plant Physiol
Endoreplication, also known as endoreduplication, is a modified cell cycle in which DNA is replicated without subsequent cell division. Endoreplication plays important roles in both normal plant development and in stress responses. TheSIAMESE(SIM) ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc65502510251b8b1f04db6a9e29da9
Autor:
Philipp Kaldis, Nathan Palmer
Publikováno v:
Seminars in celldevelopmental biology. 107
Cyclin-dependent kinases (CDKs) are activated by cyclins, which play important roles in dictating the actions of CDK/cyclin complexes. Cyclin binding influences the substrate specificity of these complexes in addition to their susceptibility to inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9985403a690cb5037d54b61f41a00409
https://pubmed.ncbi.nlm.nih.gov/32386818
https://pubmed.ncbi.nlm.nih.gov/32386818
Autor:
Abir Majumdar, Gianluigi Veglia, Andrew R. Thompson, Tiffany A. Engel, Manu Veliparambil Subrahmanian, Nicholas M. Levinson, David D. Thomas, Joseph M. Muretta, David J. Burban, Damien M. Rasmussen
Publikováno v:
Nature chemical biology
Cyclin-dependent kinases (CDKs) are the master regulators of the eukaryotic cell cycle. To become activated, CDKs require both regulatory phosphorylation and binding of a cognate cyclin subunit. We studied the activation process of the G1/S kinase Cd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718f99a0223b2986545629535aa25c49
https://pubmed.ncbi.nlm.nih.gov/33526892
https://pubmed.ncbi.nlm.nih.gov/33526892
SummaryThe initiation of DNA replication involves the cell cycle-dependent assembly and disassembly of protein complexes, including the Origin Recognition Complex (ORC) and CDC6 AAA+ ATPases. We report that multiple short, linear protein motifs (SLiM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210a76b11c69987715935ccf6caa6280
https://doi.org/10.1101/681668
https://doi.org/10.1101/681668
Autor:
Jikui Song, Boxiao Wang
Publikováno v:
Protein Sci
Protein science : a publication of the Protein Society, vol 28, iss 9
Protein science : a publication of the Protein Society, vol 28, iss 9
Progression of cell cycle is regulated by sequential expression of cyclins, which associate with distinct cyclin kinases to drive the transition between different cell cycle phases. The complex of Cyclin A with cyclin-dependent kinase 2 (CDK2) contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c5fd97317b6de3faf02528b383a36a
https://pubmed.ncbi.nlm.nih.gov/31309634
https://pubmed.ncbi.nlm.nih.gov/31309634