The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development

Autor: Mathie Tenenbaum, Amar Abderrahmani, Amélie Bonnefond, Stéphane Dalle, Julien Bourry, Valery Gmyr, Philippe Froguel, Valérie Pawlowski, Nicole Beeler, Valérie Plaisance, Raphael Boutry, Hélène Ezanno, Clara Sanchez-Parra, Cécile Jacovetti, Romano Regazzi, Gianni Pasquetti, François Pattou, Syu-Ichi Hirai, Julie Kerr-Conte

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, 2021, 78 (1), pp.287-298. ⟨10.1007/s00018-020-03499-7⟩
Cellular and molecular life sciences, vol. 78, no. 1, pp. 287-298
Cellular and Molecular Life Sciences, Springer Verlag, 2021, 78 (1), pp.287-298. ⟨10.1007/s00018-020-03499-7⟩

International audience; Unveiling the key pathways underlying postnatal beta-cell proliferation can be instrumental to decipher the mechanisms of beta-cell mass plasticity to increased physiological demand of insulin during weight gain and pregnancy.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfdfb9a0f864edaf26216a8dbe28497
https://hal.science/hal-03142227/document

Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3', 5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells

Autor: Fukushima, Toshiaki, Nedachi, T., Akizawa, H., Akahori, M., Hakuno, F., Takahashi, S.

Publikováno v: Endocrinology. 149(No. 7):3729-42

Bioactivities of IGFs in various cells are often potentiated in the presence of other hormones. In previous studies we showed that pretreatment of rat FRTL-5 thyroid cells with TSH or other cAMP-generating agents markedly potentiated DNA synthesis in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fea5e94e5e29c526e804f5ad80e66e9
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100786952

Clinical Implications of Phosphorylated STAT3 Expression in De Novo Diffuse Large B-cell Lymphoma

Autor: Santiago Montes-Moreno, Jane N. Winter, April Chiu, Youli Zu, Eric D. Hsi, Chi Young Ok, Govind Bhagat, Francesco Bertoni, Zijun Y. Xu-Monette, William W.L. Choi, Karen Dybkær, Jooryung Huh, Miguel A. Piris, Attilio Orazi, Carlo Visco, Ken H. Young, Michael Boe Møller, L. Jeffrey Medeiros, Kristy L. Richards, Alexandar Tzankov, Andrés J.M. Ferreri, John P. Farnen, Xiaoying Zhao, Jiayu Chen, J. Han van Krieken, Ling Li, Ganiraju C. Manyam, Maurilio Ponzoni

Publikováno v: Clinical Cancer Research, 20, 5113-23
Ok, C Y, Chen, J, Xu-Monette, Z, Tzankov, A, Manyam, G, Li, L, Visco, C, Montes-Moreno, S, Dybkær, K, Chiu, A, Orazi, A, Zu, Y, Bhagat, G, Richards, K L, Hsi, E D, Choi, W W, van Krieken, H, Huh, J, Zhao, X, Ponzoni, M, Ferreri, A J M, Bertoni, F, Farnen, J P, Moller, M B, Piris, M A, Winter, J N, Medeiros, L J & Young, K H 2014, ' Clinical Implications of Phosphorylated STAT3 Expression in de novo Diffuse Large B-cell Lymphoma ', Clinical Cancer Research, vol. 20, no. 19, pp. 5113-5123 . https://doi.org/10.1158/1078-0432.CCR-14-0683
Europe PubMed Central
Ok, C Y, Chen, J, Xu-Monette, Z Y, Tzankov, A, Manyam, G C, Li, L, Visco, C, Montes-Moreno, S, Dybkær, K, Chiu, A, Orazi, A, Zu, Y, Bhagat, G, Richards, K L, Hsi, E D, Choi, W W L, van Krieken, J H, Huh, J, Zhao, X, Ponzoni, M, Ferreri, A J M, Bertoni, F, Farnen, J P, Møller, M B, Piris, M A, Winter, J N, Medeiros, L J & Young, K H 2014, ' Clinical Implications of Phosphorylated STAT3 Expression in De Novo Diffuse Large B-cell Lymphoma ', Clinical Cancer Research, vol. 20, no. 19, pp. 5113-5123 . https://doi.org/10.1158/1078-0432.CCR-14-0683
Clinical Cancer Research, 20, 19, pp. 5113-23

Purpose: Activated signal transducer and activator of transcription 3 (STAT3) regulates tumor growth, invasion, cell proliferation, angiogenesis, immune response, and survival. Data regarding expression of phosphorylated (activated) STAT3 in diffuse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98dccfb0a1658c1dd850301bc9d538e
http://hdl.handle.net/2066/139215

Relating genotype and phenotype in breast cancer: an analysis of the prognostic significance of amplification at eight different genes or loci and of p53 mutations

Autor: Cuny, M., Kramar, A., Courjal, F., Johannsdottir, V., Iacopetta, B., Fontaine, H., Grenier, J., Culine, S., Charles Theillet

Publikováno v: Cancer Research
Cancer Research, American Association for Cancer Research, 2000, 60 (4), pp.1077--83
Europe PubMed Central
Scopus-Elsevier

Breast cancer heterogeneity can be related directly to its variability at the genetic level. Thus, tumor genotyping could be a valuable approach to define breast tumor subtypes. It has been shown that it is possible to delineate subgroups of breast t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a2a9aa0cba0a176e8d22fbb751e25086
https://hal.archives-ouvertes.fr/hal-02196812