Zobrazeno 1 - 10
of 1 267
pro vyhledávání: '"Cyclic nucleotide-binding domain"'
Autor:
Nour El Dine Kassab, Verena Mehlfeld, Jennifer Kass, Martin Biel, Gerhard Schneider, Gerhard Rammes
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8613 (2023)
Previous studies have shown that xenon reduces hyperpolarization-activated cyclic nucleotide-gated channels type-2 (HCN2) channel-mediated current (Ih) amplitude and shifts the half-maximal activation voltage (V1/2) in thalamocortical circuits of acu
Externí odkaz:
https://doaj.org/article/255cf73eae714ce390925bc4ddfd5407
Autor:
Arooma Maryam, Rana Rehan Khalid, Sundeep Chaitanya Vedithi, Abdulilah ECE, Suleyman Selim Çınaroğlu, Abdul Rauf Siddiqi, Tom L. Blundell
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1625-1638 (2020)
Protein kinase Iα (PKGIα) is a pivotal cyclic guanosine monophosphate (cGMP) signalling protein. Major steps related to the structural plasticity of PKGIα have been inferred but the structural aspects of the auto-inhibition and multidomain tertiar
Externí odkaz:
https://doaj.org/article/8e1da6b6ed9d4382b8d4c7287cadec20
Autor:
Morihiro Shimizu, Xinya Mi, Futoshi Toyoda, Akiko Kojima, Wei-Guang Ding, Yutaka Fukushima, Mariko Omatsu-Kanbe, Hirotoshi Kitagawa, Hiroshi Matsuura
Publikováno v:
Biomolecules, Vol 12, Iss 4, p 570 (2022)
Propofol is a broadly used intravenous anesthetic agent that can cause cardiovascular effects, including bradycardia and asystole. A possible mechanism for these effects is slowing cardiac pacemaker activity due to inhibition of the hyperpolarization
Externí odkaz:
https://doaj.org/article/b4dddb0eb6514f6bac72991bfed421cc
Akademický článek
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Publikováno v:
Current Proteomics. 19:83-90
Background: The association of a drug with its target protein correlates to its medicinal activity and the microenvironment plays a key role in this association. The key challenge is to identify mutations which unlikely to respond to designed drugs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb03808d6d25176fadb0a71fe20d0ba
https://doi.org/10.2174/1570164618666210413111223
https://doi.org/10.2174/1570164618666210413111223
Publikováno v:
Acta Crystallographica Section D Structural Biology. 77:1516-1534
More than one third of proteins require metal ions to accomplish their functions, making them obligatory for the growth and survival of microorganisms in varying environmental niches. In prokaryotes, besides their involvement in various cellular and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1c337c217bcc493c64030954e90d751
https://doi.org/10.1107/s2059798321010457
https://doi.org/10.1107/s2059798321010457
Autor:
Sayani Mukherjee, Sulagno Chakraborty, P. Raghuraman, Sriroopreddy Ramireddy, J. Sreeshma, C. Sudandiradoss
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 40:1198-1219
The human NBD domain which is centrally located in the NOD2 protein displays an essential role in oligomerization and initiates the immune response via CARD-RIPK2 interaction. The mutations associated with the NBD domain have been largely implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a77205573e3cbb36f0c1ba8679bd8a5
https://doi.org/10.1080/15257770.2021.1986719
https://doi.org/10.1080/15257770.2021.1986719
Autor:
Ajay K. Saxena, Arkita Bandyopadhyay
Publikováno v:
International Journal of Biological Macromolecules. 189:879-889
The EccC enzyme of ESX-1 system contains (i) a membrane bound Rv3870 with single ATPase domain and (ii) a cytoplasmic Rv3871 with two ATPase domains and involved in secretion of ESAT6/CFP10 factor out of the cell. In current study, we have structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ad04f68f6e91d174814327c65c0b08
https://doi.org/10.1016/j.ijbiomac.2021.08.130
https://doi.org/10.1016/j.ijbiomac.2021.08.130
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology. 57:1-15
Among the enzyme lineages that undoubtedly emerged prior to the last universal common ancestor is the so-called HUP, which includes Class I aminoacyl tRNA synthetases (AARSs) as well as enzymes mediating NAD, FAD, and CoA biosynthesis. Here, we provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c062f0d2fea4e5ae0adb05369aa94ff
https://doi.org/10.1080/10409238.2021.1957764
https://doi.org/10.1080/10409238.2021.1957764
Akademický článek
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