Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Cyclic dinucleotide"'
Publikováno v:
Cancer Biology & Medicine, Vol 21, Iss 1, Pp 45-64 (2024)
The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer treatment. Within this landscape, the innate immune system, a critical sentinel protecting against tumor incursion,
Externí odkaz:
https://doaj.org/article/09fcc989d5ec40d98dcb81e068af9469
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) are intracellular mediators of innate immune responses to cytosolic pathogen-derived and host DNA. STING agonists designed to mimic the natural host STING ligand, 2′
Externí odkaz:
https://doaj.org/article/254ced2f2c2f4d24acdaa19798d3e639
Autor:
Xifang Zhu, Eric Baranowski, Zhiyu Hao, Xixi Li, Gang Zhao, Yaqi Dong, Yingyu Chen, Changmin Hu, Huanchun Chen, Christine Citti, Aiping Wang, Aizhen Guo
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Nucleotide second messengers play an important role in bacterial adaptation to environmental changes. Recent evidence suggests that some of these regulatory molecular pathways were conserved upon the degenerative evolution of the wall-less mycoplasma
Externí odkaz:
https://doaj.org/article/da8b3fb2f75b413a9213fc92461bf1aa
Autor:
Huan Zheng, Beibei Guo, Xinyun Qiu, Yifeng Xia, Yan Qu, Liang Cheng, Fenghua Meng, Zhiyuan Zhong
Publikováno v:
Bioactive Materials, Vol 16, Iss , Pp 1-11 (2022)
Cyclic dinucleotides (CDNs) as stimulator of interferon genes (STING) agonists capable of inducing strong antitumor innate immune response are highly promising for tumor immunotherapy. The efficacy of these CDNs is, however, reduced greatly by their
Externí odkaz:
https://doaj.org/article/4a1756f79f7b40ad808effe5ad579f31
Akademický článek
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Akademický článek
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Autor:
Kenneth I. Onyedibe, Samira Elmanfi, Uma K. Aryal, Eija Könönen, Ulvi Kahraman Gürsoy, Herman O. Sintim
Publikováno v:
Journal of Oral Microbiology, Vol 14, Iss 1 (2022)
Background Constant exposure of human gingival fibroblasts (HGFs) to oral pathogens trigger selective immune responses. Recently, the activation of immune response to cyclic dinucleotides (CDNs) via STING has come to the forefront. Reports show that
Externí odkaz:
https://doaj.org/article/089d68cb15c74567bb228e8b29baabd7
Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The cGAS-cGAMP-STING pathway is an important innate immune signaling cascade responsible for the sensing of abnormal cytosolic double-stranded DNA (dsDNA), which is a hallmark of infection or cancers. Recently, tremendous progress has been made in th
Externí odkaz:
https://doaj.org/article/f2389d11b36c492985c5ef9ac1530ad4
Publikováno v:
Molecular Cancer, Vol 19, Iss 1, Pp 1-16 (2020)
Abstract The activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor immunity by generating type I interferons. In recent decades, we have witnessed that producing dsDNA upon various stimuli is an initiative factor, trigge
Externí odkaz:
https://doaj.org/article/1a3a5f9c1e634b2399290780c6f964c1