Zobrazeno 1 - 10
of 406
pro vyhledávání: '"Cyclic GMP-AMP synthase"'
Autor:
Ryo Kanoda, Shotaro Nakajima, Satoshi Fukai, Motonobu Saito, Katsuharu Saito, Hiroya Suzuki, Tomohiro Kikuchi, Azuma Nirei, Hirokazu Okayama, Kosaku Mimura, Hiroyuki Hanayama, Wataru Sakamoto, Tomoyuki Momma, Zenichiro Saze, Koji Kono
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) gastric cancer (GC) exhibits an immune-active tumor microenvironment (TME) compared to MMR proficient (pMMR)/microsatellite stable/Epstein-Barr virus-negative [EBV (−
Externí odkaz:
https://doaj.org/article/57decaa1a5db4788a29f6759405f3d95
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 7, Pp 959-964 (2024)
Objective To explore the role of DExD/H box helicase 60(DDX60) in the development of systemic lupus erythematosus (SLE) by regulating the dsDNA-cGAS-IFN-Ⅰ pathway. Methods Differences in DDX60 mRNA level in peripheral blood mononuclear cells (PBMCs
Externí odkaz:
https://doaj.org/article/5d1a7df73a7249a6994b8a5b66bde0e9
Autor:
Junyang Liu, Weijia Zhao, Jie Guo, Kaiwen Kang, Hua Li, Xiaohang Yang, Jie Li, Qiang Wang, Haifa Qiao
Publikováno v:
Brain Research Bulletin, Vol 216, Iss , Pp 111036- (2024)
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by the progressive destruction of the neuromuscular junction (NMJ) and the degeneration of motor neurons, eventually leading to atrophy and paralysis of voluntary muscl
Externí odkaz:
https://doaj.org/article/cf790683d52a4de8a38e31609703c803
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Background Pyroptosis belongs to a unique type of programmed cell death among which GSDME is reported to exert anti-tumor immunity. However, the underlying mechanisms of how to boost tumor-infiltrating lymphocytes and whether it could benefi
Externí odkaz:
https://doaj.org/article/088e64b85cdd483d9d6ec043a6d24ab7
Autor:
Weihua Yu, Jionghuang Chen, Yifan Tong, Linghua Zhu, Yuezheng Deng, Junju He, Chenxi Zhong, Xiujun Cai
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e37592- (2024)
Metabolic enzymes play significant roles in tumor growth via nonmetabolic biological processes. However, more research is needed to understand their roles in immune modulation. This study revealed that 3-hydroxysteroid dehydrogenase (NSDHL) expressio
Externí odkaz:
https://doaj.org/article/bc189a73217645f7b3ec651e4549f42c
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
As a canonical cytoplasmic DNA sensor, cyclic GMP-AMP synthase (cGAS) plays a key role in innate immunity. In recent years, a growing number of studies have shown that cGAS can also be located in the nucleus and plays new functions such as regulating
Externí odkaz:
https://doaj.org/article/a3605497f24a469ea5f3c89dfb39701c
Autor:
Martijn G. S. Rutten, Yu Lei, Joanne H. Hoogerland, Vincent W. Bloks, Hong Yang, Trijnie Bos, Kishore A. Krishnamurthy, Aycha Bleeker, Mirjam H. Koster, Rachel E. Thomas, Justina C. Wolters, Hilda van den Bos, Gilles Mithieux, Fabienne Rajas, Adil Mardinoglu, Diana C. J. Spierings, Alain de Bruin, Bart van de Sluis, Maaike H. Oosterveer
Publikováno v:
Cancer & Metabolism, Vol 11, Iss 1, Pp 1-11 (2023)
Abstract Background Glycogen storage disease type 1a (GSD Ia) is an inborn error of metabolism caused by a defect in glucose-6-phosphatase (G6PC1) activity, which induces severe hepatomegaly and increases the risk for liver cancer. Hepatic GSD Ia is
Externí odkaz:
https://doaj.org/article/176971327ab64839a0921d89e984a866
Autor:
Han Bao, Jinqi Yan, Jiancheng Huang, Wenjuan Deng, Ce Zhang, Cong Liu, Ailing Huang, Qiao Zhang, Ying Xiong, Qiang Wang, Huanghui Wu, Lichao Hou
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-16 (2023)
Abstract Background The “missing” link of complex and multifaceted interplay among endogenous retroviruses (ERVs) transcription, chronic immuno-inflammation, and the development of psychiatric disorders is still far from being completely clarifie
Externí odkaz:
https://doaj.org/article/6fcf5a483c004b87a3a53f2f2968c08b
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Akademický článek
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