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pro vyhledávání: '"Cyclic/chemistry/pharmacology"'
Autor:
Stéphane Baeriswyl, Sacha Javor, Christian van Delden, Ivan Di Bonaventura, Giovanni Di Bonaventura, Thissa N. Siriwardena, Jean-Louis Reymond, Alice Capecchi, Arianna Pompilio, Xian Jin, Thilo Köhler, Runze He, Bee Ha Gan
Publikováno v:
Chemical Communications, Vol. 54, No 40 (2018) pp. 5130-5133
We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against sev