Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Cyanohydrin reaction"'
Autor:
Prof. Dr. Antonín Klásek, Assoc. Prof. Dr. Stanislav Kafka, Dr. Ondřej Rudolf, Prof. Dr. Antonín Lyčka, Dr. Michal Rouchal, Lukáš Bednář
Publikováno v:
ChemistryOpen, Vol 10, Iss 6, Pp 645-652 (2021)
Abstract 3‐Chloroquinoline‐2,4‐diones react with cyanide ions in dimethyl formamide to give 3‐cyanoquinoline‐2,4‐diones in small yields due to the strong hindrance of the substituent at the C‐3 atom. Good yields can be achieved if the s
Externí odkaz:
https://doaj.org/article/f90df3e12a9d48aabf37c3aaf0819a52
Publikováno v:
ChemistryOpen, Vol 10, Iss 6, Pp 645-652 (2021)
ChemistryOpen
ChemistryOpen
3-Chloroquinoline-2,4-diones react with cyanide ions in dimethyl formamide to give 3-cyanoquinoline-2,4-diones in small yields due to the strong hindrance of the substituent at the C-3 atom. Good yields can be achieved if the substituent at this posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fe1abe0165ea27e30a893f1d555a93
https://doaj.org/article/f90df3e12a9d48aabf37c3aaf0819a52
https://doaj.org/article/f90df3e12a9d48aabf37c3aaf0819a52
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Publikováno v:
Chemical Research in Chinese Universities. 30:770-773
The authors described a short and highly enantioselective route to (R)-salmeterol involving asymmetric synthesis of cyanohydrin followed by nucleophilic substitution with 6-(4-phenylbutoxy) hexyl methanesulfonate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24b371a139c0e4a1316e435937b2a423
https://doi.org/10.1007/s40242-014-4073-3
https://doi.org/10.1007/s40242-014-4073-3
Publikováno v:
ChemCatChem. 2:981-986
Hydroxynitrile lyase from Hevea brasiliensis (HbHNL) is a promiscuous biocatalyst that, besides the native cyanohydrin reaction, also catalyzes the asymmetric Henry reaction yielding (5)-β-nitroalcohols with high enantiomeric excess. Since the Henry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc3828e39f011024f30d28ee3f1b46bd
https://doi.org/10.1002/cctc.201000147
https://doi.org/10.1002/cctc.201000147
Autor:
Karl Gruber, Manuela Avi, Juliane Keilitz, Herfried Griengl, Georg Steinkellner, Rainer Haag, Chakib Hajji
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 61:268-273
3,4-Dihydro-2H-pyran-2-carbaldehyde (1) and 2-methoxycyclohex-3-encarbaldehyde (2) obtained by thermal or chemocatalytic Diels–Alder reactions were converted into the corresponding cyanohydrins by hydroxynitrile lyase catalysis. Modelling investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d26370ab9accb37122e8873cf771a1f9
https://doi.org/10.1016/j.molcatb.2009.08.005
https://doi.org/10.1016/j.molcatb.2009.08.005
Publikováno v:
Tetrahedron. 65:5418-5426
A de novo synthesis of pentoses is described starting from (Z)-2-buten-1,4-diol (1). The key step is the enzyme catalysed enantioselective HCN-addition to O-protected 4-hydroxybut-2-enal using the hydroxynitrile lyase from Hevea brasiliensis, followe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc5f62b33328e48ffe10800ea72e27df
https://doi.org/10.1016/j.tet.2009.04.048
https://doi.org/10.1016/j.tet.2009.04.048
Autor:
Martin Fechter, Christian Schuster, Karl Gruber, Kurt O. Klepp, Manuela Avi, Peter Pöchlauer, Wolfgang Skranc, Herfried Griengl
Publikováno v:
Chemistry - A European Journal. 13:3369-3376
3-Tetrahydrothiophenone (4) and 4-phenylthiobutan-2-one (7) were used as masked 2-butanone equivalents to give the corresponding cyanohydrins 5 (79 % yield, 91 % ee) and 8 (95 % yield, 96 % ee) in an enzymatic cyanohydrin reaction applying the hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20d2c44769135cdbd3c08977d13cedd
https://doi.org/10.1002/chem.200601114
https://doi.org/10.1002/chem.200601114
Autor:
and Oliver Maurer, Cor Van Den Broek, Wolfgang Skranc, Thomas Purkarthofer, Thomas Pabst, Herfried Griengl
Publikováno v:
Organic Process Research & Development. 10:618-621
A two-step chemoenzymatic synthesis of (R)-2-amino-1-(2-furyl)ethanol for laboratory production was developed followed by successful up-scaling to kilogram scale. The generation of the asymmetric centre was accomplished by a highly enantioselective c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28c943f44edbc12109d1e4db83be6f3c
https://doi.org/10.1021/op050264b
https://doi.org/10.1021/op050264b
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 11:213-218
The ( S )-selective hydroxynitrile lyase from Hevea brasiliensis ( Hb HNL) catalyzes the trans -cyanohydrin reaction (transcyanation). The equilibrium of this two-step reaction sequence is not favorable unless a large excess of acetone cyanohydrin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::752e1b261e99f2a9ceaf08d519420bda
https://doi.org/10.1016/s1381-1177(00)00061-8
https://doi.org/10.1016/s1381-1177(00)00061-8