Zobrazeno 1 - 9
of 9
pro vyhledávání: '"CyP, cyclophilin"'
Autor:
Robert Thimme, Volker Lohmann, K. Nitschke, Katharina Esser-Nobis, Christoph Neumann-Haefelin, Julia Schmidt
Publikováno v:
Journal of Hepatology
Graphical abstract
Background & Aims Cyclophilin-inhibitors have potent antiviral activity against Hepatitis C virus (HCV) and are promising candidates for broad-spectrum antiviral therapy. Cyclosporine A (CsA) acts immunosuppressive by blocking
Background & Aims Cyclophilin-inhibitors have potent antiviral activity against Hepatitis C virus (HCV) and are promising candidates for broad-spectrum antiviral therapy. Cyclosporine A (CsA) acts immunosuppressive by blocking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f395b4bff5d87f5bc39248a12632325c
https://doi.org/10.1016/j.jhep.2016.02.027
https://doi.org/10.1016/j.jhep.2016.02.027
Autor:
Fabio Di Lisa, Paolo Bernardi
Publikováno v:
Journal of Molecular and Cellular Cardiology
The mitochondrial permeability transition (PT) – an abrupt increase permeability of the inner membrane to solutes – is a causative event in ischemia–reperfusion injury of the heart, and the focus of intense research in cardioprotection. The PT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48153568f5aefe237a4b56960be7b044
http://europepmc.org/articles/PMC4294587
http://europepmc.org/articles/PMC4294587
Publikováno v:
Redox Biology
Redox Biology, Vol 13, Iss C, Pp 170-181 (2017)
Redox Biology, Vol 13, Iss C, Pp 170-181 (2017)
Liver failure induced by systemic inflammatory response (SIRS) is often associated with mitochondrial dysfunction but the mechanism linking SIRS and mitochondria-mediated liver failure is still a matter of discussion. Current hypotheses suggest that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f697788e470a2706f5078bc09c454862
https://pubmed.ncbi.nlm.nih.gov/28578275
https://pubmed.ncbi.nlm.nih.gov/28578275
Publikováno v:
Biochimica et Biophysica Acta
A prolonged period of ischaemia followed by reperfusion irreversibly damages the heart. Such reperfusion injury (RI) involves opening of the mitochondrial permeability transition pore (MPTP) under the conditions of calcium overload and oxidative stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8075a2de6528998b690f0f2eee5cab
https://doi.org/10.1016/j.bbabio.2007.05.008
https://doi.org/10.1016/j.bbabio.2007.05.008
Autor:
Henry Dube, Michela Capano, Michela I. Simone, Sylvanie Malouitre, Martin Crompton, David L. Selwood
Publikováno v:
Biochemical Journal
Mitochondrial CyP-D (cyclophilin-D) catalyses formation of the PT (permeability transition) pore, a key lesion in the pathogenesis of I/R (ischaemia/reperfusion) injury. There is evidence [Malouitre, Dube, Selwood and Crompton (2010) Biochem. J. 425,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d702d9b47f8e6f29b3290b5e5bfdb276
https://pubmed.ncbi.nlm.nih.gov/22035570
https://pubmed.ncbi.nlm.nih.gov/22035570
Publikováno v:
Biochemical Journal, 425 (1) pp. 137-148. (2009)
Biochemical Journal
Biochemical Journal
CsA (cyclosporin A) is a hydrophobic undecapeptide that inhibits CyPs (cyclophilins), a family of PPIases (peptidylprolyl cis–trans isomerases). In some experimental models, CsA offers partial protection against lethal cell injury brought about by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2d69f30d30190847179c0a3479a03d
https://discovery.ucl.ac.uk/id/eprint/20029/
https://discovery.ucl.ac.uk/id/eprint/20029/
Autor:
Udayan Chatterji, S. Phillips, Shilpa Chokshi, Roger Williams, Philippe Gallay, Antonio Riva, Michael Bobardt, Nikolai V. Naoumov
Publikováno v:
Gastroenterology
Background & Aims Cyclophilins are host factors required for hepatitis C virus replication. Cyclophilin inhibitors such as alisporivir have shown strong anti–hepatitis C virus activity in vitro and in clinical studies. However, little is known abou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01162d6497048777ae4c1c1c4d1bf9ac
http://europepmc.org/articles/PMC7172380
http://europepmc.org/articles/PMC7172380
Kniha
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Kniha
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.