Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Cy A. Stein"'
Autor:
Daniela Castanotto, Xiaowei Zhang, Jacqueline Rüger, Jessica Alluin, Ritin Sharma, Patrick Pirrotte, Lars Joenson, Silvia Ioannou, Michael S. Nelson, Jonas Vikeså, Bo Rode Hansen, Troels Koch, Mads Aaboe Jensen, John J. Rossi, Cy A. Stein
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 63-75 (2021)
The androgen receptor (AR) plays a critical role in the development of prostate cancer (PCa) through the activation of androgen-induced cellular proliferation genes. Thus, blocking AR-mediated transcriptional activation is expected to inhibit the gro
Externí odkaz:
https://doaj.org/article/05d438d8c2914f6a92b4a9a5650737aa
Autor:
Sanjay Goel, Cy A. Stein
Antisense oligonucleotide therapeutics have been in development for almost 25 years without a single U.S. Food and Drug Administration–approved product in cancer. The reasons for this absence stem, in part, from a deep lack of understanding about h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b778626486e76df5e58b61f87deb25
https://doi.org/10.1158/1078-0432.c.6520170
https://doi.org/10.1158/1078-0432.c.6520170
Autor:
Sanjay Goel, Cy A. Stein
Related Article from Therapeutic Oligonucleotides: The Road Not Taken
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017f1d1ae477f28826a3696a278a4282
https://doi.org/10.1158/1078-0432.22444443.v1
https://doi.org/10.1158/1078-0432.22444443.v1
Autor:
Cy A. Stein
Publikováno v:
Loss and Grief ISBN: 0197524532
It was not until my internship and residency program, at age thirty-two, that I suffered the greatest loss of my life. This involved what I perceived as a complete loss of agency due to my perception of a catastrophic diminution in my status as a val
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4882c3aca299b98a6a84dd676e04163c
https://doi.org/10.1093/med/9780197524534.003.0017
https://doi.org/10.1093/med/9780197524534.003.0017
Autor:
Ritin Sharma, Jessica Alluin, Silvia Ioannou, Lars Joenson, Troels Koch, Patrick Pirrotte, Mads Jensen, Xiaowei Zhang, Jonas Vikeså, Bo Hansen, Daniela Castanotto, Michael S. Nelson, Cy A. Stein, John J. Rossi, Jacqueline Rüger
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 23, Iss, Pp 63-75 (2021)
Molecular Therapy: Nucleic Acids, Vol 23, Iss, Pp 63-75 (2021)
The androgen receptor (AR) plays a critical role in the development of prostate cancer (PCa) through the activation of androgen-induced cellular proliferation genes. Thus, blocking AR-mediated transcriptional activation is expected to inhibit the gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54d6d446a5a4e378fce224945040926
https://pubmed.ncbi.nlm.nih.gov/33335793
https://pubmed.ncbi.nlm.nih.gov/33335793
Autor:
Marcin Kortylewski, Tanya B. Dorff, David I. Quinn, Cy A. Stein, Timothy W. Synold, Edwin M. Posadas
Publikováno v:
Cancer biotherapyradiopharmaceuticals. 35(7)
The effects of radium-223 on the immune system and the bone tumor microenvironment are incompletely understood. The authors describe mechanisms by which radium-223 may interact with the immune system, specifically through STAT-3 and impact on tumor a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661443c9a10580ca4aef2d2ca1ea5264
https://pubmed.ncbi.nlm.nih.gov/32366119
https://pubmed.ncbi.nlm.nih.gov/32366119
Autor:
Naira Souleimanian, Glen F Deleavey, Harris Soifer, Sijian Wang, Katrin Tiemann, Masad J Damha, Cy A Stein
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Gymnosis is the process of the delivery of antisense oligodeoxynucleotides to cells, in the absence of any carriers or conjugation, that produces sequence-specific gene silencing. While gymnosis was originally demonstrated using locked nucleic acid (
Externí odkaz:
https://doaj.org/article/39e6966d99634c2498c59a0aad4adae0
Publikováno v:
Nucleic Acids Research
Oligonucleotide (ON) concentrations employed for therapeutic applications vary widely, but in general are high enough to raise significant concerns for off target effects and cellular toxicity. However, lowering ON concentrations reduces the chances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4e02527f86567923b87c1e632f316b
https://doi.org/10.1093/nar/gky150
https://doi.org/10.1093/nar/gky150
Publikováno v:
Oncology and Therapy. 5:161-170
Abiraterone acetate (AA) is approved for treatment of metastatic castration-resistant prostate cancer. The originator AA (OAA) formulation has been associated with AUC and C max increases of 10- and 17-fold, respectively, when administered following
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dce0fd4653bac503a9b3f5a0793c336
https://doi.org/10.1007/s40487-017-0054-2
https://doi.org/10.1007/s40487-017-0054-2
Publikováno v:
Bohr, H G, Shim, I, Stein, C, Ørum, H, Hansen, H F & Koch, T 2017, ' Electronic Structures of LNA Phosphorothioate Oligonucleotides ', Molecular Therapy-Nucleic Acids, vol. 8, pp. 428-441 . https://doi.org/10.1016/j.omtn.2017.05.011
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 8, Iss, Pp 428-441 (2017)
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 8, Iss, Pp 428-441 (2017)
Important oligonucleotides in anti-sense research have been investigated in silico and experimentally. This involves quantum mechanical (QM) calculations and chromatography experiments on locked nucleic acid (LNA) phosphorothioate (PS) oligonucleotid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a79582c0a8bf77729d7d4a2d7cf227
https://doi.org/10.1016/j.omtn.2017.05.011
https://doi.org/10.1016/j.omtn.2017.05.011