Mouse models for the study of telomerase

Autor: Maria A. Blasco, Hw, Lee, Rizen M, Hanahan D, DePinho R, Cw, Greider

Publikováno v: Europe PubMed Central

The ends of chromosomes, or telomeres, consist of short repeated sequences that are synthesized by a ribonucleoprotein-DNA polymerase called telomerase. The RNA component of telomerase is essential for enzyme activity. The maintenance of telomere len

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e44a3b6d5c7d21ef9cfdd2c6a50fdb27
https://pubmed.ncbi.nlm.nih.gov/9524757

Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes.

Autor: Keener R; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Chhetri SB; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Connelly CJ; Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, MD, USA., Taub MA; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Conomos MP; Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Weinstock J; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Ni B; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA., Strober B; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA., Aslibekyan S; University of Alabama at Birmingham, Birmingham, AL, USA., Auer PL; Division of Biostatistics, Institute for Health & Equity, and Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA., Barwick L; LTRC Data Coordinating Center, The Emmes Company, LLC, Rockville, MD, USA., Becker LC; GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Bleecker ER; Department of Medicine, Division of Genetics, Genomics and Precision Medicine, University of Arizona, Tucson, AZ, USA.; Division of Pharmacogenomics, University of Arizona, Tucson, AZ, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Cade BE; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Celedon JC; Division of Pediatric Pulmonary Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Chang YC; Department of Internal Medicine, National Taiwan University, Taipei, Taiwan.; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; The National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA., Custer B; Vitalant Research Institute, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA., Freedman BI; Internal Medicine - Nephrology, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Gladwin MT; School of Medicine, University of Maryland, Baltimore, MD, USA., Heckbert SR; Department of Epidemiology, University of Washington, Seattle, WA, USA., Hou L; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Evanston, IL, USA., Irvin MR; Department of Epidemiology, University of Alabama Birmingham, Birmingham, AL, USA., Isasi CR; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Johnsen JM; Department of Medicine and Institute for Stem Cell & Regenerative Medicine, University of Washington, Seattle, WA, USA., Kenny EE; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Minster RL; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA., Naseri T; Naseri & Associates Public Health Consultancy Firm and Family Health Clinic, Apia, Samoa.; International Health Institute, School of Public Health, Brown University, Providence, RI, USA., Viali S; Oceania University of Medicine, Apia, Samoa.; School of Medicine, National University of Samoa, Apia, Samoa.; Department of Chronic Disease Epidemiology, Yale University School of Public Health, New Haven, CT, USA., Nekhai S; Center for Sickle Cell Disease and Department of Medicine, College of Medicine, Howard University, Washington DC, USA., Pankratz N; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Telen MJ; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Wu B; Center for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA., Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Yang IV; Departments of Biomedical Informatics, Medicine, and Epidemiology, University of Colorado, Boulder, CO, USA., Albert C; Harvard Medical School, Boston, MA, USA.; Division of Cardiovascular, Brigham and Women's Hospital, Boston, MA, USA., Arnett DK; Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA., Ashley-Koch AE; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Barnes KC; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Blackwell TW; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Burchard EG; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA., Carson AP; Department of Medicine, University of Mississippi Medical Center, Jackson, MI, USA., Chen Z; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Darbar D; Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA., de Andrade M; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA., Ellinor PT; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fornage M; Institute of Molecular Medicine, McGovern Medical School, the University of Texas Health Science Center at Houston, Houston, TX, USA., Gelb BD; Mindich Child Health and Development Institute and Departments of Pediatrics and Genetics and Genomic Sciences, Icahn School of Medicine, New York, NY, USA., Gilliland FD; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., He J; Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA., Islam T; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., Kaab S; Department of Cardiology, University Hospital, LMU Munich, Munich, Germany., Kardia SLR; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Kelly S; Vitalant Research Institute, San Francisco, CA, USA.; University of California San Francisco Benioff Children's Hospital, Oakland, CA, USA., Konkle BA; Department of Medicine, University of Washington, Seattle, WA, USA., Kumar R; Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; The Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Martinez FD; Asthma & Airway Disease Research Center, University of Arizona, Tucson, AZ, USA., McGarvey ST; Department of Epidemiology & International Health Institute, Brown University School of Public Health, Providence, RI, USA., Meyers DA; Department of Medicine, Division of Genetics, Genomics and Precision Medicine, University of Arizona, Tucson, AZ, USA.; Division of Pharmacogenomics, University of Arizona, Tucson, AZ, USA., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Montgomery CG; Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., North KE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Palmer ND; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Peralta JM; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Raby BA; Division of Pulmonary and Critical Care, Brigham and Women's Hospital, Boston, MA, USA.; Division of Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA., Redline S; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Rich SS; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Roden D; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Ruczinski I; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Schwartz D; Departments of Medicine and Immunology, University of Colorado, Boulder, CO, USA., Sciurba F; Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Shoemaker MB; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Silverman EK; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Sinner MF; Department of Cardiology, University Hospital, LMU Munich, Munich, Germany., Smith NL; Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA., Smith AV; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Tiwari HK; Department of Biostatistics, University of Alabama Birmingham, Birmingham, AL, USA., Vasan RS; Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Weiss ST; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Williams LK; Center for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA., Zhang Y; Division of Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Ziv E; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Reiner AP; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Arvanitis M; Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA., Greider CW; Department of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, USA.; University Professor Johns Hopkins University, Baltimore, MD, USA., Mathias RA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. rmathias@jhmi.edu., Battle A; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. ajbattle@jhu.edu.; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA. ajbattle@jhu.edu.; Department of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA. ajbattle@jhu.edu.; Malone Center for Engineering in Healthcare, Johns Hopkins University, Baltimore, MD, USA. ajbattle@jhu.edu.; Data Science and AI Institute, Johns Hopkins University, Baltimore, MD, USA. ajbattle@jhu.edu.

Publikováno v: Nature communications [Nat Commun] 2024 May 24; Vol. 15 (1), pp. 4417. Date of Electronic Publication: 2024 May 24.

Human telomere length is chromosome specific and conserved across individuals.

Autor: Karimian K; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Groot A; Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz., Huso V; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Kahidi R; University of Calgary, Calgary, AB, Canada., Tan KT; Harvard Medical School, Department of Genetics, Boston, MA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Broad Institute, Cancer Program, Cambridge, MA., Sholes S; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Present address Merck & Co., 770 Sumneytown Pike, West Point, PA 19486., Keener R; Department of Biomedical Engineering, Johns Hopkins University., McDyer JF; Pulmonary, Allergy, Critical Care, and Sleep Medicine Division, Department of Medicine, University of Pittsburgh., Alder JK; Pulmonary, Allergy, Critical Care, and Sleep Medicine Division, Department of Medicine, University of Pittsburgh., Li H; Dana-Farber Cancer Institute, Department of Data Sciences, Boston, MA.; Harvard Medical School, Department of Biomedical Informatics, Boston, MA., Rechtsteiner A; Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz., Greider CW; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 13. Date of Electronic Publication: 2024 Jan 13.

Chromosome-specific telomere lengths and the minimal functional telomere revealed by nanopore sequencing.

Autor: Sholes SL; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Karimian K; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Gershman A; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Kelly TJ; Program in Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Timp W; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Greider CW; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.; Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, California 95064, USA.

Publikováno v: Genome research [Genome Res] 2022 Apr; Vol. 32 (4), pp. 616-628. Date of Electronic Publication: 2021 Oct 26.

Rif1 regulates telomere length through conserved HEAT repeats.

Autor: Shubin CB; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Mayangsari R; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA., Swett AD; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Greider CW; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2021 Apr 19; Vol. 49 (7), pp. 3967-3980.