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Generation of proliferating human adult hepatocytes using optimized 3D culture conditions

Autor: Rose, Sophie, Ezan, Frédéric, Cuvellier, Marie, Bruyère, Arnaud, Legagneux, Vincent, Langouët, Sophie, Baffet, Georges

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.515. ⟨10.1038/s41598-020-80019-4⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports, 2021, 11 (1), pp.515. ⟨10.1038/s41598-020-80019-4⟩

International audience; Generating the proliferation of differentiated normal adult human hepatocytes is a major challenge and an expected central step in understanding the microenvironmental conditions that regulate the phenotype of human hepatocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e6654466e51c58a40a6597145e4b58da
https://hal.archives-ouvertes.fr/hal-03134402/file/s41598-020-80019-4.pdf

In vitro long term differentiation and functionality of three-dimensional bioprinted primary human hepatocytes: application for in vivo engraftment

Autor: Marie Cuvellier, Sophie Rose, Frédéric Ezan, Ulrich Jarry, Hugo de Oliveira, Arnaud Bruyère, Christophe Drieu La Rochelle, Vincent Legagneux, Sophie Langouët, Georges Baffet

Publikováno v: Biofabrication
Biofabrication, 2022, 14 (3), pp.035021. ⟨10.1088/1758-5090/ac7825⟩

In recent decades, 3D in vitro cultures of primary human hepatocytes (PHHs) have been increasingly developed to establish models capable of faithfully mimicking main liver functions. The use of 3D bioprinting, capable of recreating structures compose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24696cb58c3e4a1bfd25c326486c066
https://univ-rennes.hal.science/hal-03710469/document

Natural Food Flavors and Colorants

Autor: Mathew Attokaran

Although many foods are appealing, and even perceived as natural, in spite of containing synthetic additives, consumer increasingly prefer food products which are fully natural. This has driven an increase in the use of, and interest in, food additiv