Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Cutler T. Lewandowski"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 3, Pp 995-1018 (2022)
The function of ATP binding cassette protein A1 (ABCA1) is central to cholesterol mobilization. Reduced ABCA1 expression or activity is implicated in Alzheimer's disease (AD) and other disorders. Therapeutic approaches to boost ABCA1 activity have ye
Externí odkaz:
https://doaj.org/article/24039ed219364d9b9d4d416974d46336
Autor:
Cutler T. Lewandowski, Md.Wasim Khan, Manel BenAissa, Oleksii Dubrovskyi, Martha Ackerman-Berrier, Mary Jo LaDu, Brian T. Layden, Gregory R.J. Thatcher
Publikováno v:
EBioMedicine, Vol 66, Iss , Pp 103287- (2021)
Background: Therapeutic agents with novel mechanisms of action are needed to combat the growing epidemic of type 2 diabetes (T2D) and related metabolic syndromes. Liver X receptor (LXR) agonists possess preclinical efficacy yet produce side effects d
Externí odkaz:
https://doaj.org/article/5277fbac50654f85b635af85f115f0b3
Publikováno v:
Neurobiology of Disease, Vol 139, Iss , Pp 104811- (2020)
The focus on amyloid plaques and neurofibrillary tangles has yielded no Alzheimer’s disease (AD) modifying treatments in the past several decades, despite successful studies in preclinical mouse models. This inconsistency has caused a renewed focus
Externí odkaz:
https://doaj.org/article/1379ff67320a44a3a603417af7830e78
Autor:
Brian T. Layden, Md. Wasim Khan, Manel Ben Aissa, Cutler T. Lewandowski, Gregory R. J. Thatcher
Publikováno v:
Circulation. 142
Introduction: Reduced expression of cholesterol transporter ABCA1 is critical in pathogenesis of type 2 diabetes (T2D) and related conditions, such as cardiovascular disease (CVD) and Alzheimer’s disease (AD). Thus, increasing ABCA1 represents a no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::881ae014b3bf70b9eb9a02fb8a45ddf8
https://doi.org/10.1161/circ.142.suppl_3.15297
https://doi.org/10.1161/circ.142.suppl_3.15297
Autor:
Mary Jo LaDu, Brian T. Layden, Sue H. Lee, Kiira Ratia, Cutler T. Lewandowski, Manel Ben Aissa, Gregory R. J. Thatcher
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Selective liver X receptor (LXR) agonists have been extensively pursued as therapeutics for Alzheimer’s disease and related dementia (ADRD) and, for comorbidities such as type 2 diabetes (T2D) and cerebrovascular disease (CVD), di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771c52cb81e31b5ba02d778f2ce463a6
https://pubmed.ncbi.nlm.nih.gov/33615168
https://pubmed.ncbi.nlm.nih.gov/33615168
Autor:
Manel BenAissa, Md. Wasim Khan, Brian T. Layden, Martha Ackerman-Berrier, Cutler T. Lewandowski, Oleksii Dubrovskyi, Mary Jo LaDu, Gregory R. J. Thatcher
Publikováno v:
EBioMedicine
EBioMedicine, Vol 66, Iss, Pp 103287-(2021)
EBioMedicine, Vol 66, Iss, Pp 103287-(2021)
Background Therapeutic agents with novel mechanisms of action are needed to combat the growing epidemic of type 2 diabetes (T2D) and related metabolic syndromes. Liver X receptor (LXR) agonists possess preclinical efficacy yet produce side effects du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98df9df31a09648d7660732015b434b7
https://pubmed.ncbi.nlm.nih.gov/33857903
https://pubmed.ncbi.nlm.nih.gov/33857903
Publikováno v:
Neurobiol Dis
Neurobiology of Disease, Vol 139, Iss, Pp 104811-(2020)
Neurobiology of Disease, Vol 139, Iss, Pp 104811-(2020)
The focus on amyloid plaques and neurofibrillary tangles has yielded no Alzheimer’s disease (AD) modifying treatments in the past several decades, despite successful studies in preclinical mouse models. This inconsistency has caused a renewed focus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5d9c1cacc49461c96b7db91bbf8103
https://pubmed.ncbi.nlm.nih.gov/32087290
https://pubmed.ncbi.nlm.nih.gov/32087290
Autor:
Cutler T. Lewandowski, Sue H. Lee, Manel Ben Aissa, Bhargava Karumudi, Gregory R. J. Thatcher
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ac24dc6e9550be74fc223419e7c48ea
https://doi.org/10.1016/j.jalz.2018.06.076
https://doi.org/10.1016/j.jalz.2018.06.076
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39f926482166bd26296361c027c08f7e
https://doi.org/10.1016/j.jalz.2018.06.3026
https://doi.org/10.1016/j.jalz.2018.06.3026
Publikováno v:
Alzheimer's & Dementia. 15:P264-P265
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d6f69584a55ac51cc16f5897e72acf3
https://doi.org/10.1016/j.jalz.2019.06.103
https://doi.org/10.1016/j.jalz.2019.06.103