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The Effect of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Ertugliflozin in Subjects With Type 2 Diabetes Mellitus

Autor: Sahasrabudhe, V., Terra, S. G., Hickman, A., Saur, D., Shi, H., O'Gorman, M., Zhou, Z., Cutler, D. L.

Publikováno v: Journal of Clinical Pharmacology

Ertugliflozin is a highly selective and potent inhibitor of the sodium‐glucose cotransporter 2 in development for the treatment of type 2 diabetes mellitus. The glycemic efficacy of sodium‐glucose cotransporter 2 inhibitors such as ertugliflozin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77b3b1b699c6cc3d371ec5df03e15b2d
http://europepmc.org/articles/PMC5655776

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Akademický článek

Safety, tolerability and pharmacokinetics after single and multiple doses of preladenant (SCH420814) administered in healthy subjects.

Autor: Cutler, D. L.¹, Tendolkar, A.¹, Grachev, I. D.²

Publikováno v: Journal of Clinical Pharmacy & Therapeutics. Oct2012, Vol. 37 Issue 5, p578-587. 10p.

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Akademický článek

Solubilization of Paclitaxel with Natural Compound Rubusoside toward Improving Oral Bioavailability in a Rodent Model.

Autor: Zhang, Jian^1,2 (AUTHOR) jianzhang@sina.com, Shu, Jicheng^1,3 (AUTHOR) shujc210@jxutcm.edu.cn, Stout, Rhett W.⁴ (AUTHOR) rstout1@lsu.edu, Russo, Paul S.⁵ (AUTHOR) paul.russo@mse.gatech.edu, Liu, Zhijun¹ (AUTHOR) zliu@agcenter.lsu.edu

Publikováno v: Pharmaceutics. Aug2024, Vol. 16 Issue 8, p1104. 13p.

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Akademický článek

IL-10 and Cdc42 modulate astrocyte-mediated microglia activation in methamphetamine-induced neuroinflammation.

Autor: Silva AI; Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal.; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.; Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal., Socodato R; Glia Cell Biology Group, i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal., Pinto C; Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal.; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal., Terceiro AF; Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal.; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.; Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal., Canedo T; Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal.; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal., Relvas JB; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.; Glia Cell Biology Group, i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal.; Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal., Saraiva M; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.; Immune Regulation Group, i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal., Summavielle T; Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal.; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.; ESS.PP, Escola Superior de Saúde do Politécnico do Porto, Porto, Portugal.

Publikováno v: Glia [Glia] 2024 Aug; Vol. 72 (8), pp. 1501-1517. Date of Electronic Publication: 2024 May 23.

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Attenuation of proinflammatory response by recombinant human IL-10 in human endotoxemia: effect of timing of recombinant human IL-10 administration

Autor: Pajkrt, D., Camoglio, L., Tiel-van Buul, M. C., de Bruin, K., Cutler, D. L., Affrime, M. B., Rikken, G., van der Poll, T., ten Cate, J. W., van Deventer, S. J.

Publikováno v: The journal of immunology, 158, 3971-3977. American Association of Immunologists
Journal of immunology (Baltimore, Md., 158(8), 3971-3977. American Association of Immunologists

To determine the effects of IL-10 on cytokine and granulocyte responses during endotoxemia, two groups of eight healthy male volunteers were challenged with endotoxin (4 ng/kg) on two occasions, once in combination with placebo injection, and once in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2270802d45de40f2ecfe2908e802f885
https://dare.uva.nl/personal/pure/en/publications/attenuation-of-proinflammatory-response-by-recombinant-human-il10-in-human-endotoxemia-effect-of-timing-of-recombinant-human-il10-administration(9babeb8b-9af3-4dfd-81a2-66de3a228ffc).html

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Interleukin-10 inhibits activation of coagulation and fibrinolysis during human endotoxemia

Autor: Pajkrt, D., van der Poll, T., Levi, M. [=Marcel M.], Cutler, D. L., Affrime, M. B., van den Ende, A., ten Cate, J. W., van Deventer, S. J.

Publikováno v: Blood, 89(8), 2701-2705. American Society of Hematology

Interleukin-10 (IL-10) has been found to inhibit lipopolysaccharide (LPS)-induced tissue factor expression by monocytes in vitro. To determine the effects of IL-10 on LPS-induced activation of the hemostatic mechanisms in vivo, we performed a placebo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::d84ff34ce4cc67fa03be6a76c6aa3bf0
https://pure.amc.nl/en/publications/interleukin10-inhibits-activation-of-coagulation-and-fibrinolysis-during-human-endotoxemia(d3348093-00f2-4082-b855-41f65a958fc9).html

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